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1.
Br J Surg ; 101(11): 1373-82; discussion 1382, 2014 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-25146918

RESUMEN

BACKGROUND: Postoperative pain is an important adverse event following inguinal hernia repair. The aim of this trial was to compare postoperative pain within the first 3 months and 1 year after surgery in patients undergoing open mesh inguinal hernia repair using either a self-gripping lightweight polyester mesh or a polypropylene lightweight mesh fixed with sutures. METHODS: Adult men undergoing Lichtenstein repair for primary inguinal hernia were randomized to ProGrip™ self-gripping mesh or standard sutured lightweight polypropylene mesh. RESULTS: In total 557 men were included in the final analysis (self-gripping mesh 270, sutured mesh 287). Early postoperative pain scores were lower with self-gripping mesh than with sutured lightweight mesh: mean visual analogue pain score relative to baseline +1·3 and +8·6 respectively at discharge (P = 0·033), and mean surgical pain scale score relative to baseline +4·2 and +9·7 respectively on day 7 (P = 0·027). There was no significant difference in mid-term (1 month) and long-term (3 months and 1 year) pain scores between the groups. Surgery was significantly quicker with self-gripping mesh (mean difference 7·6 min; P < 0·001). There were no significant differences in reported mesh handling, analgesic consumption, other wound complications, patient satisfaction or hernia recurrence between the groups. CONCLUSION: Self-gripping mesh for open inguinal hernia repair was well tolerated and reduced early postoperative pain (within the first week), without increasing the risk of early recurrence. It did not reduce chronic pain. REGISTRATION NUMBER: NCT00827944 (http://www.clinicaltrials.gov).


Asunto(s)
Hernia Inguinal/cirugía , Herniorrafia/métodos , Mallas Quirúrgicas , Análisis de Varianza , Humanos , Complicaciones Intraoperatorias/etiología , Masculino , Persona de Mediana Edad , Tratamientos Conservadores del Órgano , Dolor Postoperatorio/etiología , Polipropilenos/uso terapéutico , Técnicas de Sutura , Suturas , Traumatismos del Sistema Nervioso/complicaciones , Resultado del Tratamiento
2.
Hernia ; 20(1): 33-41, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-25862026

RESUMEN

PURPOSE: A large randomized, multicenter European study recently reported a reduction in early pain after open inguinal surgery when self-gripping mesh was used compared with sutured Lichtenstein repair. This secondary exploratory study is focused on the influence of nerve identification and handling on post-operative pain. METHODS: Post-operative VAS pain data and Surgical Pain Scores (SPS) from 507 patients included in this study were analyzed according to whether inguinal nerves were preserved or resected during surgery to investigate whether identification and peri-operative nerve handling impact post-operative pain. RESULTS: Preservation of the ilio-hypogastric nerve during Lichtenstein mesh repair with suture fixation was associated with significantly more post-operative pain compared with resection at each follow-up (p ≤ 0.003). This difference was not significant with self-gripping mesh repair. The decrease from baseline in post-operative VAS and SPS scores were significantly greater after self-gripping mesh repair compared to Lichtenstein repair at 1 year, but only when the ilio-hypogastric nerve was preserved (VAS scores, p = 0.009; SPS scores, p = 0.015). No such difference was observed with the ilio-inguinal nerve. When self-gripping mesh was used, preservation of the ilio-hypogastric nerve was associated with significantly greater decreases in post-operative pain (change in VAS score from baseline) compared with Lichtenstein repair at each follow-up (p ≤ 0.018). CONCLUSIONS: The ilio-hypogastric nerve is in danger of being traumatized during Lichtenstein mesh repair with suture fixation. The use of self-gripping mesh was shown to reduce the level of post-operative pain when the ilio-hypogastric nerve was preserved. Resection of the ilio-hypogastric nerve during Lichtenstein repair eliminates this difference.


Asunto(s)
Hernia Inguinal/cirugía , Herniorrafia/efectos adversos , Herniorrafia/métodos , Plexo Lumbosacro/cirugía , Mallas Quirúrgicas , Técnicas de Sutura/efectos adversos , Adulto , Anciano , Humanos , Masculino , Persona de Mediana Edad , Neuralgia/etiología , Dolor Postoperatorio/etiología
3.
Transplant Proc ; 45(1): 46-50, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-23267785

RESUMEN

Delayed graft function (DGF) is a major issue in kidney transplantation and is associated with reduced graft and patient survival. The condition results from the summative effects of multiple injurious processes associated with transplantation with many underlying factors being nonmodifiable. Reducing cold ischemic time and machine perfusion have decreased the DGF incidence but peri-/postoperative injury resulting from suboptimal perfusion may also be critical to the development of DGF. We investigated the effect of perfusion parameters and other key variables on the incidence of DGF in 149 consecutive renal transplants. The occurrence of any recorded subtarget (70 mm Hg) mean arterial pressure (MAP) was significantly associated with DGF (perioperative P = .005; postoperative P = .002) while the occurrence of a subtarget (8 cm H(2)O) central venous pressure (CVP) among other variables was not. Routine continuous blood pressure monitoring is rare postoperatively and is shown to be more accurate than CVP in assessing renal perfusion and guiding management in the postoperative period.


Asunto(s)
Presión Arterial , Presión Venosa Central , Funcionamiento Retardado del Injerto/fisiopatología , Trasplante de Riñón/métodos , Adulto , Isquemia Fría , Funcionamiento Retardado del Injerto/diagnóstico , Femenino , Rechazo de Injerto/fisiopatología , Supervivencia de Injerto/fisiología , Humanos , Riñón/patología , Masculino , Persona de Mediana Edad , Preservación de Órganos , Perfusión , Periodo Posoperatorio , Curva ROC , Factores de Riesgo , Factores de Tiempo , Resultado del Tratamiento
4.
Hernia ; 16(3): 287-94, 2012 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-22453675

RESUMEN

PURPOSE: To compare clinical outcomes following sutureless Parietex™ ProGrip™ mesh repair to traditional Lichtenstein repair with lightweight polypropylene mesh secured with sutures. METHODS: This is a 3-month interim report of a 1-year multicenter international study. Three hundred and two patients were randomized; 153 were treated with Lichtenstein repair (L group) and 149 with Parietex™ ProGrip™ precut mesh (P group) with or without fixation. The primary outcome measure was postoperative pain using the visual analog scale (VAS, 0-150 mm); other outcomes were assessed prior to surgery and up to 3 months postoperatively. RESULTS: Compared to baseline, pain score was lower in the P group at discharge (-10%) and at 7 days (-13%), while pain increased in the L group at discharge (+39%) and at 7 days (+21%). The difference between groups was significant at both time points (P = 0.007 and P = 0.039, respectively). In the P group, patients without fixation suffered less pain compared to those with single-suture fixation (1 month: -20.9 vs. -6.15%, P = 0.02; 3 months: -24.3 vs. -7.7%, P = 0.01). The infection rate was significantly lower in the P group during the 3-month follow-up (2.0 vs. 7.2%, P = 0.032). Surgery duration was significantly shorter in the P group (32.4 vs. 39.1 min; P < 0.001). No recurrence was observed at 3 months in both groups. CONCLUSIONS: Surgery duration, early postoperative, pain and infection rates were significantly reduced with self-gripping polyester mesh compared to Lichtenstein repair with polypropylene mesh. The use of fixation increased postoperative pain in the P group. The absence of early recurrence highlights the gripping efficiency effect.


Asunto(s)
Hernia Inguinal/cirugía , Herniorrafia/efectos adversos , Herniorrafia/instrumentación , Dolor Postoperatorio/etiología , Mallas Quirúrgicas/efectos adversos , Adulto , Anciano , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Poliésteres/efectos adversos , Polipropilenos/efectos adversos , Recurrencia , Infección de la Herida Quirúrgica/etiología , Suturas/efectos adversos , Factores de Tiempo
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