RESUMEN
Objective To study the clinical effect of low molecular weight heparin on fetal growth restriction (FGR) prevention in early pregnancy.Methods 100 pregnant women had been employed in our study,they were divided into two groups,observation( n =60) and control( n =40) group.Both groups were given the natural vitamin E 0.1g,and folie acid 0.4mg daily oral administration,continuing to 12 weeks of gestation.5000 u of subcutaneous dalteparin sodium was added to pregnant women with notmal level of D-dimer in the observation group until 12 weeks of pregnancy,while the dose of Fragmin was adjusted in pregnant women with abnormal level of D-dimer until retuned to normal level.The pregnacy outcome of two groups were compared.Results The gestational age,birth weight,placental weight of the obseruation group was signiticantly higher than thal of the control group ( t =4.55,2.79,11.91,all P ＜ 0.05 ),while FGR,oligohydramnies,fetal distress and the incidence of hypertensive disorters of the obseruation group were significantly lower than that of control group ( x2 =6.50,20.55,7.87,3.76,all P ＜ 0.05 ) ; Compared to the control group,the observation group didn't have higher incidence of intrauterine fetal death,neonatal asphyxia and perinatal death ( P ＞ 0.05).Conclusion Low molecular weight heparin using in early pregnancy was effective in preventing FGR in pregnant women with FGR risk factors.