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Bioorg Med Chem Lett
; 30(22): 127536, 2020 11 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32898695
RESUMEN
The identification and SAR development of a series of negative allosteric modulators of the GABAA α5 receptor is described. This novel series of compounds was optimised to provide analogues with high GABAA α5 binding affinity, high α5 negative allosteric modulatory activity, good functional subtype selectivity and low microsomal turnover, culminating in identification of ONO-8590580.