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1.

Adagrasib in Non-Small-Cell Lung Cancer Harboring a KRAS^G12C Mutation.

Jänne, Pasi A; Riely, Gregory J; Gadgeel, Shirish M; Heist, Rebecca S; Ou, Sai-Hong I; Pacheco, Jose M; Johnson, Melissa L; Sabari, Joshua K; Leventakos, Konstantinos; Yau, Edwin; Bazhenova, Lyudmila; Negrao, Marcelo V; Pennell, Nathan A; Zhang, Jun; Anderes, Kenna; Der-Torossian, Hirak; Kheoh, Thian; Velastegui, Karen; Yan, Xiaohong; Christensen, James G; Chao, Richard C; Spira, Alexander I.

N Engl J Med ; 387(2): 120-131, 2022 07 14.

Artículo en Inglés | MEDLINE | ID: mdl-35658005

2.

Acquired Resistance to KRAS^G12C Inhibition in Cancer.

Awad, Mark M; Liu, Shengwu; Rybkin, Igor I; Arbour, Kathryn C; Dilly, Julien; Zhu, Viola W; Johnson, Melissa L; Heist, Rebecca S; Patil, Tejas; Riely, Gregory J; Jacobson, Joseph O; Yang, Xiaoping; Persky, Nicole S; Root, David E; Lowder, Kristen E; Feng, Hanrong; Zhang, Shannon S; Haigis, Kevin M; Hung, Yin P; Sholl, Lynette M; Wolpin, Brian M; Wiese, Julie; Christiansen, Jason; Lee, Jessica; Schrock, Alexa B; Lim, Lee P; Garg, Kavita; Li, Mark; Engstrom, Lars D; Waters, Laura; Lawson, J David; Olson, Peter; Lito, Piro; Ou, Sai-Hong I; Christensen, James G; Jänne, Pasi A; Aguirre, Andrew J.

N Engl J Med ; 384(25): 2382-2393, 2021 06 24.

Artículo en Inglés | MEDLINE | ID: mdl-34161704

3.

Capmatinib in MET Exon 14-Mutated or MET-Amplified Non-Small-Cell Lung Cancer.

Wolf, Jürgen; Seto, Takashi; Han, Ji-Youn; Reguart, Noemi; Garon, Edward B; Groen, Harry J M; Tan, Daniel S W; Hida, Toyoaki; de Jonge, Maja; Orlov, Sergey V; Smit, Egbert F; Souquet, Pierre-Jean; Vansteenkiste, Johan; Hochmair, Maximilian; Felip, Enriqueta; Nishio, Makoto; Thomas, Michael; Ohashi, Kadoaki; Toyozawa, Ryo; Overbeck, Tobias R; de Marinis, Filippo; Kim, Tae-Min; Laack, Eckart; Robeva, Anna; Le Mouhaer, Sylvie; Waldron-Lynch, Maeve; Sankaran, Banu; Balbin, O Alejandro; Cui, Xiaoming; Giovannini, Monica; Akimov, Mikhail; Heist, Rebecca S.

N Engl J Med ; 383(10): 944-957, 2020 09 03.

Artículo en Inglés | MEDLINE | ID: mdl-32877583

4.

Lung cancer.

Thai, Alesha A; Solomon, Benjamin J; Sequist, Lecia V; Gainor, Justin F; Heist, Rebecca S.

Lancet ; 398(10299): 535-554, 2021 08 07.

Artículo en Inglés | MEDLINE | ID: mdl-34273294

5.

Phase II Study of Cabozantinib in Patients With Bone Metastasis.

Choy, Edwin; Cote, Gregory M; Michaelson, M Dror; Wirth, Lori; Gainor, Justin F; Muzikansky, Alona; Sequist, Lecia V; Sullivan, Ryan J; Fidias, Panagiotis M; Shaw, Alice; Heist, Rebecca S.

Oncologist ; 27(7): 600-606, 2022 07 05.

Artículo en Inglés | MEDLINE | ID: mdl-35524758

6.

Implementation and Clinical Adoption of Precision Oncology Workflows Across a Healthcare Network.

Dias-Santagata, Dora; Heist, Rebecca S; Bard, Adam Z; da Silva, Annacarolina F L; Dagogo-Jack, Ibiayi; Nardi, Valentina; Ritterhouse, Lauren L; Spring, Laura M; Jessop, Nicholas; Farahani, Alexander A; Mino-Kenudson, Mari; Allen, Jill; Goyal, Lipika; Parikh, Aparna; Misdraji, Joseph; Shankar, Ganesh; Jordan, Justin T; Martinez-Lage, Maria; Frosch, Matthew; Graubert, Timothy; Fathi, Amir T; Hobbs, Gabriela S; Hasserjian, Robert P; Raje, Noopur; Abramson, Jeremy; Schwartz, Joel H; Sullivan, Ryan J; Miller, David; Hoang, Mai P; Isakoff, Steven; Ly, Amy; Bouberhan, Sara; Watkins, Jaclyn; Oliva, Esther; Wirth, Lori; Sadow, Peter M; Faquin, William; Cote, Gregory M; Hung, Yin P; Gao, Xin; Wu, Chin-Lee; Garg, Salil; Rivera, Miguel; Le, Long P; John Iafrate, A; Juric, Dejan; Hochberg, Ephraim P; Clark, Jeffrey; Bardia, Aditya; Lennerz, Jochen K.

Oncologist ; 27(11): 930-939, 2022 11 03.

Artículo en Inglés | MEDLINE | ID: mdl-35852437

7.

Phase 1 study of epacadostat in combination with atezolizumab for patients with previously treated advanced nonsmall cell lung cancer.

Hellmann, Matthew D; Gettinger, Scott; Chow, Laura Q M; Gordon, Michael; Awad, Mark M; Cha, Edward; Gong, Xiaohua; Zhou, Gongfu; Walker, Chris; Leopold, Lance; Heist, Rebecca S.

Int J Cancer ; 147(7): 1963-1969, 2020 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-32141617

8.

Revisiting MET: Clinical Characteristics and Treatment Outcomes of Patients with Locally Advanced or Metastatic, MET-Amplified Esophagogastric Cancers.

Chaudhary, Surendra Pal; Kwak, Eunice L; Hwang, Katie L; Lennerz, Jochen K; Corcoran, Ryan B; Heist, Rebecca S; Russo, Andrea L; Parikh, Aparna; Borger, Darrell R; Blaszkowsky, Lawrence S; Faris, Jason E; Murphy, Janet E; Azzoli, Christopher G; Roeland, Eric J; Goyal, Lipika; Allen, Jill; Mullen, John T; Ryan, David P; Iafrate, A John; Klempner, Samuel J; Clark, Jeffrey W; Hong, Theodore S.

Oncologist ; 25(11): e1691-e1700, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-32820577

9.

A phase Ib dose-escalation and expansion study of the oral MEK inhibitor pimasertib and PI3K/MTOR inhibitor voxtalisib in patients with advanced solid tumours.

Schram, Alison M; Gandhi, Leena; Mita, Monica M; Damstrup, Lars; Campana, Frank; Hidalgo, Manuel; Grande, Enrique; Hyman, David M; Heist, Rebecca S.

Br J Cancer ; 119(12): 1471-1476, 2018 12.

Artículo en Inglés | MEDLINE | ID: mdl-30425349

10.

Rociletinib in EGFR-mutated non-small-cell lung cancer.

Sequist, Lecia V; Soria, Jean-Charles; Goldman, Jonathan W; Wakelee, Heather A; Gadgeel, Shirish M; Varga, Andrea; Papadimitrakopoulou, Vassiliki; Solomon, Benjamin J; Oxnard, Geoffrey R; Dziadziuszko, Rafal; Aisner, Dara L; Doebele, Robert C; Galasso, Cathy; Garon, Edward B; Heist, Rebecca S; Logan, Jennifer; Neal, Joel W; Mendenhall, Melody A; Nichols, Suzanne; Piotrowska, Zofia; Wozniak, Antoinette J; Raponi, Mitch; Karlovich, Chris A; Jaw-Tsai, Sarah; Isaacson, Jeffrey; Despain, Darrin; Matheny, Shannon L; Rolfe, Lindsey; Allen, Andrew R; Camidge, D Ross.

N Engl J Med ; 372(18): 1700-9, 2015 Apr 30.

Artículo en Inglés | MEDLINE | ID: mdl-25923550

11.

Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer.

Heist, Rebecca S; Duda, Dan G; Sahani, Dushyant V; Ancukiewicz, Marek; Fidias, Panos; Sequist, Lecia V; Temel, Jennifer S; Shaw, Alice T; Pennell, Nathan A; Neal, Joel W; Gandhi, Leena; Lynch, Thomas J; Engelman, Jeffrey A; Jain, Rakesh K.

Proc Natl Acad Sci U S A ; 112(5): 1547-52, 2015 Feb 03.

Artículo en Inglés | MEDLINE | ID: mdl-25605928

12.

MET Exon 14 Skipping in Non-Small Cell Lung Cancer.

Heist, Rebecca S; Shim, Hyo Sup; Gingipally, Shalini; Mino-Kenudson, Mari; Le, Long; Gainor, Justin F; Zheng, Zongli; Aryee, Martin; Xia, Junfeng; Jia, Peilin; Jin, Hailing; Zhao, Zhongming; Pao, William; Engelman, Jeffrey A; Iafrate, A John.

Oncologist ; 21(4): 481-6, 2016 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-27022036

13.

Inconsistency and features of single nucleotide variants detected in whole exome sequencing versus transcriptome sequencing: A case study in lung cancer.

O'Brien, Timothy D; Jia, Peilin; Xia, Junfeng; Saxena, Uma; Jin, Hailing; Vuong, Huy; Kim, Pora; Wang, Qingguo; Aryee, Martin J; Mino-Kenudson, Mari; Engelman, Jeffrey A; Le, Long P; Iafrate, A John; Heist, Rebecca S; Pao, William; Zhao, Zhongming.

Methods ; 83: 118-27, 2015 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-25913717

14.

Clinical management, monitoring, and prophylaxis of adverse events of special interest associated with datopotamab deruxtecan.

Heist, Rebecca S; Sands, Jacob; Bardia, Aditya; Shimizu, Toshio; Lisberg, Aaron; Krop, Ian; Yamamoto, Noboru; Kogawa, Takahiro; Al-Hashimi, Saba; Fung, Simon S M; Galor, Anat; Pisetzky, Francesca; Basak, Priyanka; Lau, Cindy; Meric-Bernstam, Funda.

Cancer Treat Rev ; 125: 102720, 2024 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-38502995

15.

Phase I/II Study of Combined BCL-xL and MEK Inhibition with Navitoclax and Trametinib in KRAS or NRAS Mutant Advanced Solid Tumors.

Corcoran, Ryan B; Do, Khanh T; Kim, Jeong E; Cleary, James M; Parikh, Aparna R; Yeku, Oladapo O; Xiong, Niya; Weekes, Colin D; Veneris, Jennifer; Ahronian, Leanne G; Mauri, Gianluca; Tian, Jun; Norden, Bryanna L; Michel, Alexa G; Van Seventer, Emily E; Siravegna, Giulia; Camphausen, Kyle; Chi, Gary; Fetter, Isobel J; Brugge, Joan S; Chen, Helen; Takebe, Naoko; Penson, Richard T; Juric, Dejan; Flaherty, Keith T; Sullivan, Ryan J; Clark, Jeffrey W; Heist, Rebecca S; Matulonis, Ursula A; Liu, Joyce F; Shapiro, Geoffrey I.

Clin Cancer Res ; 30(9): 1739-1749, 2024 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-38456660

16.

Activating point mutations in the MET kinase domain represent a unique molecular subset of lung cancer and other malignancies targetable with MET inhibitors.

Pecci, Federica; Nakazawa, Seshiru; Ricciuti, Biagio; Harada, Guilherme; Lee, Jessica K; Alessi, Joao V; Barrichello, Adriana; Vaz, Victor R; Lamberti, Giuseppe; Di Federico, Alessandro; Gandhi, Malini M; Gazgalis, Dimitris; Feng, William W; Jiang, Jie; Baldacci, Simon; Locquet, Marie-Anais; Gottlieb, Felix H; Chen, Monica F; Lee, Elinton; Haradon, Danielle; Smokovich, Anna; Voligny, Emma; Nguyen, Tom; Goel, Vikas K; Zimmerman, Zachary; Atwal, Sumandeep; Wang, Xinan; Bahcall, Magda; Heist, Rebecca S; Iqbal, Sumaiya; Gandhi, Nishant; Elliott, Andrew; Vanderwalde, Ari M; Ma, Patrick C; Halmos, Balazs; Liu, Stephen V; Che, Jianwei; Schrock, Alexa B; Drilon, Alexander; Janne, Pasi A; Awad, Mark M.

Cancer Discov ; 2024 Apr 03.

Artículo en Inglés | MEDLINE | ID: mdl-38564707

17.

Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma.

Renouf, Daniel J; Zhai, Rihong; Sun, Bin; Xu, Wei; Cheung, Winson Y; Heist, Rebecca S; Kulke, Matthew H; Cescon, David; Asomaning, Kofi; Marshall, Ariella L; Li, Su; Christiani, David C; Liu, Geoffrey.

J Gastroenterol Hepatol ; 28(9): 1482-8, 2013 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-23735059

18.

Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients.

Duda, Dan G; Heist, Rebecca S; Sahani, Dushyant V; Stylianopoulos, Triantafyllos; Engelman, Jeffrey A; Jain, Rakesh K.

Proc Natl Acad Sci U S A ; 112(27): E3454, 2015 Jul 07.

Artículo en Inglés | MEDLINE | ID: mdl-26080434

19.

New Therapies on the Horizon.

Cooper, Alissa J; Heist, Rebecca S.

Hematol Oncol Clin North Am ; 37(3): 623-658, 2023 06.

Artículo en Inglés | MEDLINE | ID: mdl-37029036

20.

Intracranial Efficacy of Adagrasib in Patients From the KRYSTAL-1 Trial With KRAS^G12C-Mutated Non-Small-Cell Lung Cancer Who Have Untreated CNS Metastases.

Negrao, Marcelo V; Spira, Alexander I; Heist, Rebecca S; Jänne, Pasi A; Pacheco, Jose M; Weiss, Jared; Gadgeel, Shirish M; Velastegui, Karen; Yang, Wenjing; Der-Torossian, Hirak; Christensen, James G; Sabari, Joshua K.

J Clin Oncol ; 41(28): 4472-4477, 2023 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-37327468

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