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1.
Eur J Neurol ; 31(5): e16211, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38235955

RESUMEN

BACKGROUND: Nonreversible hearing loss (HL) is the main sequelae of Susac syndrome (SuS). We aimed to identify risk factors for HL in SuS. METHODS: The CARESS study is a prospective national cohort study that started in December 2011, including all consecutive patients with SuS referred to the French reference center. The CARESS study was designed with a follow-up including fundoscopy, audiometry, and brain magnetic resonance imaging at 1, 3, 6, and 12 months after diagnosis and then annually for 5 years. The primary outcome was the occurrence at last follow-up of severe HL defined as the loss of 70 dB in at least one ear on audiometry or the need for hearing aids. RESULTS: Thirty-six patients (female 66.7%, median age 37.5 [range 24.5-42.5] years) included in the clinical study were analyzed for the primary outcome. Thirty-three patients (91.7%) had cochleovestibular involvement at SuS diagnosis including HL >20 dB in at least one ear in 25 cases. At diagnosis, 32 (88.9%), 11 (30.6%), and 7 (19.4%) patients had received steroids, intravenous immunoglobulin, and/or immunosuppressive (IS) drugs, respectively. After a median follow-up of 51.8 [range 29.2-77.6] months, 19 patients (52.8%) experienced severe HL that occurred a median of 13 [range 1.5-29.5] months after diagnosis. Multivariable analysis showed that the odds of severe HL were lower in patients who received IS drugs at diagnosis (OR 0.15, 95% CI 0.01-1.07, p = 0.058). CONCLUSIONS: Severe HL in SuS is associated with the absence of IS drugs given at diagnosis. Our findings support the systematic use of IS drugs in SuS.


Asunto(s)
Pérdida Auditiva , Síndrome de Susac , Humanos , Femenino , Adulto Joven , Adulto , Síndrome de Susac/complicaciones , Síndrome de Susac/epidemiología , Síndrome de Susac/diagnóstico , Estudios de Cohortes , Estudios Prospectivos , Pérdida Auditiva/epidemiología , Pérdida Auditiva/etiología , Inmunosupresores , Factores de Riesgo
2.
Eur J Neurol ; 29(1): 121-129, 2022 01.
Artículo en Inglés | MEDLINE | ID: mdl-34382290

RESUMEN

BACKGROUND: Susac syndrome (SuS) is a rare occlusive microvessel disease of the brain, retina and inner ear. We aimed to determine whether brain lesion load at the acute phase predicts poor outcomes in SuS. METHODS: A prospective national cohort study was conducted from December 2012 to December 2019 in 20 centres in France. Patients included at the principal investigator's center with available brain magnetic resonance imaging (MRI) at diagnosis were analyzed. MRI was reviewed by an experienced neuroradiologist blinded to clinical status. The size, topography and number of hyperintense lesions on diffusion-weighted imaging (DWI-HL) were analyzed at diagnosis and during follow-up. Outcomes involved descriptive characteristics of patients at onset and last follow-up. RESULTS: Twenty-three patients (38.1 [18.8-56.5] years, 16 females) were prospectively studied. The triad (i.e., brain, eye and ear involvement) was complete at onset in 17 patients. Brain MRI was performed 1.1 (0.1-3.4) months after the first symptom. All patients had DWI-HL at the acute phase. Patients were separated into two groups according to the number of DWI-HL on first MRI: a first group of patients (n=15) displaying low brain lesion load (<50 DWI-HL per patient) and a second group of patients (n=8) displaying high brain lesion load (≥100 DWI-HL). The median follow-up was 57.9 (9.7-98) months. Clinical features, treatment, relapse rate, time to disappearance of DWI-HL, disabilities and professional outcome did not differ according to brain lesion load. CONCLUSION: Brain lesion load assessed by DWI at the acute phase is not associated with risks of disability in SuS.


Asunto(s)
Síndrome de Susac , Encéfalo/diagnóstico por imagen , Encéfalo/patología , Estudios de Cohortes , Femenino , Humanos , Imagen por Resonancia Magnética/métodos , Estudios Prospectivos , Síndrome de Susac/diagnóstico por imagen , Síndrome de Susac/patología
3.
Radiology ; 297(2): E242-E251, 2020 11.
Artículo en Inglés | MEDLINE | ID: mdl-32544034

RESUMEN

Background Brain MRI parenchymal signal abnormalities have been associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Purpose To describe the neuroimaging findings (excluding ischemic infarcts) in patients with severe coronavirus disease 2019 (COVID-19) infection. Materials and Methods This was a retrospective study of patients evaluated from March 23, 2020, to April 27, 2020, at 16 hospitals. Inclusion criteria were (a) positive nasopharyngeal or lower respiratory tract reverse transcriptase polymerase chain reaction assays, (b) severe COVID-19 infection defined as a requirement for hospitalization and oxygen therapy, (c) neurologic manifestations, and (d) abnormal brain MRI findings. Exclusion criteria were patients with missing or noncontributory data regarding brain MRI or brain MRI showing ischemic infarcts, cerebral venous thrombosis, or chronic lesions unrelated to the current event. Categorical data were compared using the Fisher exact test. Quantitative data were compared using the Student t test or Wilcoxon test. P < .05 represented a significant difference. Results Thirty men (81%) and seven women (19%) met the inclusion criteria, with a mean age of 61 years ± 12 (standard deviation) (age range, 8-78 years). The most common neurologic manifestations were alteration of consciousness (27 of 37, 73%), abnormal wakefulness when sedation was stopped (15 of 37, 41%), confusion (12 of 37, 32%), and agitation (seven of 37, 19%). The most frequent MRI findings were signal abnormalities located in the medial temporal lobe in 16 of 37 patients (43%; 95% confidence interval [CI]: 27%, 59%), nonconfluent multifocal white matter hyperintense lesions seen with fluid-attenuated inversion recovery and diffusion-weighted sequences with variable enhancement, with associated hemorrhagic lesions in 11 of 37 patients (30%; 95% CI: 15%, 45%), and extensive and isolated white matter microhemorrhages in nine of 37 patients (24%; 95% CI: 10%, 38%). A majority of patients (20 of 37, 54%) had intracerebral hemorrhagic lesions with a more severe clinical presentation and a higher admission rate in intensive care units (20 of 20 patients [100%] vs 12 of 17 patients without hemorrhage [71%], P = .01) and development of the acute respiratory distress syndrome (20 of 20 patients [100%] vs 11 of 17 patients [65%], P = .005). Only one patient had SARS-CoV-2 RNA in the cerebrospinal fluid. Conclusion Patients with severe coronavirus disease 2019 and without ischemic infarcts had a wide range of neurologic manifestations that were associated with abnormal brain MRI scans. Eight distinctive neuroradiologic patterns were described. © RSNA, 2020.


Asunto(s)
Betacoronavirus , Encéfalo/diagnóstico por imagen , Encéfalo/patología , Infecciones por Coronavirus/diagnóstico por imagen , Infecciones por Coronavirus/patología , Imagen por Resonancia Magnética/métodos , Neumonía Viral/diagnóstico por imagen , Neumonía Viral/patología , Adolescente , Adulto , Anciano , COVID-19 , Niño , Estudios de Cohortes , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pandemias , Estudios Retrospectivos , SARS-CoV-2 , Adulto Joven
4.
J Geriatr Psychiatry Neurol ; 27(2): 85-93, 2014 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-24578460

RESUMEN

OBJECTIVE: To examine the diagnostic ability of the Lawton Instrumental Activities Daily Living (IADLs) scale and the Activities Daily Living (ADLs) scale as a sensitive tool to Alzheimer's disease (AD) in community-dwelling elderly people. DESIGN: In an old age memory outpatient center, among patients with a clinical diagnosis of AD dementia or no dementia supported by at least 6 months of follow-up, we looked back at the baseline Lawton IADL scale (short version IADL-4 item), ADL scale, Mini-Mental State Examination (MMSE), and Montreal Cognitive Assessment (MOCA) values. RESULTS: There were 109 patients with AD and 53 nondemented individuals (81.4 ± 4.6 years). The sensitivity of ADL scale or IADL-4 item or the MMSE was low (52%-57%). The most efficient AD classification used both the IADLs-4 item and the MOCA with a threshold score of 20. Besides age and memory scores, the main correlates of IADLs scale or ADLs scale were executive, neuropsychiatric, vascular, and extrapyramidal scores. CONCLUSION: Our results suggest that the Lawton IADLs-4 item scale and ADLs scale lack sensitivity to AD dementia in elderly people and support a better sensitivity of MOCA rather than MMSE and IADLs-4 item/ADLs at the expense of specificity.


Asunto(s)
Enfermedad de Alzheimer/diagnóstico , Demencia/diagnóstico , Encuestas y Cuestionarios/normas , Actividades Cotidianas , Anciano , Anciano de 80 o más Años , Enfermedad de Alzheimer/psicología , Demencia/psicología , Femenino , Estudios de Seguimiento , Humanos , Masculino , Memoria , Pruebas Neuropsicológicas , Reproducibilidad de los Resultados , Sensibilidad y Especificidad
5.
Brain Res ; 1222: 79-86, 2008 Jul 30.
Artículo en Inglés | MEDLINE | ID: mdl-18579121

RESUMEN

Mobility dysfunction of unknown origin predicts dementia in the elderly and is associated with periventricular leukoaraiosis (LA), another predictor of dementia of still controversial pathogenesis, in the elderly with mild cognitive impairment (MCI). Thus, this study examined which gait and balance parameters best correlate with periventricular LA to better understand the pathogenesis of mobility decline in MCI. High resolution MRI and detailed mobility assessment were performed in 61 subjects (72 years+/-5) with MCI. Cognitive assessment included Free and Cued Selective Reminding Test (FCSRT) and the Trail Making test part B (TMB). Mobility assessment included reports of falls in the previous 6-month period, the walking while talking test, the timed "up and go test" (TUG), measurement of fast gait speed, the standing test and the one-leg standing test. There was an association between marked periventricular LA and slow postural changes, slow gait (TUG and gait speed), altered balance (standing test and one-leg standing test), altered walking while talking test. But after adjusting for age and ventriculomegaly on a logistic multiple regression model, performance on the TUG test was the only clinical predictor of periventricular LA (>10 s, P=0.002). Poorer TUG performances were more frequent with vascular than Alzheimer's disease-like profiles on the FCSRT and TMB tests (P=0.01). In conclusion, the clinical profile of patients demonstrating a main MR brain correlate of mobility dysfunction supports a main pathomechanism of subtle vascular extrapyramidal dysfunction in MCI.


Asunto(s)
Encéfalo/patología , Encéfalo/fisiopatología , Trastornos del Conocimiento/complicaciones , Trastornos del Movimiento/etiología , Trastornos del Movimiento/patología , Anciano , Anciano de 80 o más Años , Distribución de Chi-Cuadrado , Femenino , Humanos , Leucoaraiosis/diagnóstico , Leucoaraiosis/fisiopatología , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Actividad Motora/fisiología , Pruebas Neuropsicológicas
7.
Curr Aging Sci ; 10(2): 129-135, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28042772

RESUMEN

BACKGROUND: Rapid Cognitive Decline (RCD) in Alzheimer's Disease (AD) is associated with a worse disease progression. There is no consensual predictor of RCD and only a few studies have focused on RCD in late-onset dementia, the most common form of AD. OBJECTIVE: To identify the predictors of RCD, in a population of community-dwelling patients with recently diagnosed late onset AD. METHODS: Community-dwelling subjects aged >75 consulting for the first time in Old Age Memory outpatient center from 2009 to 2012 were considered. All patients underwent a standardized clinical dementia investigation. Patients were classified as rapid decliners when they demonstrated a loss of 3 points or greater in MMSE during the first six months. RESULTS: 130 patients were included (42 males, 88 females, mean ages 82.7±4.58). The average baseline MMSE score was 23.36±3.78. In regression analysis, the Free Recall Scores, categorical fluency scores were the most highly predictive of RCD. CONCLUSION: These results are important for the design of clinical trials and also, in clinical practice, for both physicians and families in planning long-term care.


Asunto(s)
Enfermedad de Alzheimer/psicología , Cognición , Actividades Cotidianas , Edad de Inicio , Anciano , Anciano de 80 o más Años , Enfermedad de Alzheimer/diagnóstico , Enfermedad de Alzheimer/etiología , Comorbilidad , Análisis Discriminante , Progresión de la Enfermedad , Femenino , Humanos , Vida Independiente , Modelos Lineales , Modelos Logísticos , Masculino , Recuerdo Mental , Pruebas de Estado Mental y Demencia , Pruebas Neuropsicológicas , Paris , Pronóstico , Factores de Riesgo , Factores de Tiempo , Conducta Verbal
10.
Int J Cardiol ; 212: 63-9, 2016 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-27035605

RESUMEN

BACKGROUND: Prognostic value of the infarct- and non-infarct like patterns and cardiac magnetic resonance (CMR) parameters on long-term outcome of patients after acute myocarditis is not well known. METHODS: Between 2006 and 2015, 112 consecutive patients with CMR-based diagnosis of acute myocarditis were identified in our institution. Of them, 88 were available for clinical follow-up and represented our studied population. Patients were divided into infarct-like group (n=48) (association of acute chest pain, elevated Troponin levels and ST-elevation) and non-infarct-like group (n=40) with any other presentation. The composite primary endpoint of major cardiovascular events (MACE) included: all-cause mortality, cardiac mortality, recurrence of myocarditis, heart failure, and sustained ventricular tachycardia. RESULTS: During follow-up, 21 patients (24%) experienced MACE and infarct-like patients were significantly more at risk for MACE than non-infarct-like patients (HR 2.4, 95% CI [1.01-5.80] p=0.04). Infarct-like patients exhibited in particular a higher risk of sustained ventricular tachycardia and recurrence of myocarditis (p=0.03). They had lower CMR-derived left (p=0.03) and right (p=0.001) ventricular ejection fractions, and exhibited larger areas of late gadolinium enhancement (LGE) (p=0.001). In multivariate analysis, both initial NYHA functional class >II and LGE mass were independent predictors for long-term MACE occurrence (HR 5.8 and 1.07 per gram respectively, p=0.007). Moreover, a threshold of LGE mass >17g provided a high discrimination for MACE occurrence (AUC of 0.81). CONCLUSIONS: The infarct-like pattern of acute myocarditis is associated with MACE occurrence. Initial NYHA functional class >II and LGE are independent predictive factors of MACE during long-term follow-up after acute myocarditis.


Asunto(s)
Imagen por Resonancia Cinemagnética/tendencias , Infarto del Miocardio/diagnóstico por imagen , Infarto del Miocardio/epidemiología , Miocarditis/diagnóstico por imagen , Miocarditis/epidemiología , Enfermedad Aguda , Adulto , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Estudios Retrospectivos , Factores de Tiempo , Resultado del Tratamiento , Adulto Joven
11.
Am J Cardiol ; 118(3): 440-5, 2016 08 01.
Artículo en Inglés | MEDLINE | ID: mdl-27296557

RESUMEN

Hyperemia is a major criterion for the diagnosis of acute myocarditis on cardiac magnetic resonance imaging but its assessment is challenging and time consuming. We evaluated the usefulness of the contrast-enhanced first-pass perfusion (FPP) on magnetic resonance imaging for detecting subepicardial hyperemia in acute myocarditis. Forty-seven consecutive patients (mean age: 42 ± 15.6 years; 35 men) with a definite diagnosis of acute myocarditis according to the state-of-the-art guidelines were included and compared with 16 control subjects. FPP was evaluated by 2 blinded observers and compared with the reference late gadolinium enhancement. Detection of hyperemia was performed on both qualitative and quantitative methods. Relative increased signal intensity (SI) in the subepicardial hyperemic layer was measured with SI ratio (SI of the subepicardial layer/SI of the immediately adjacent subendocardial layer). Twenty-four patients (51%) with acute myocarditis exhibited subepicardial hyperemia, detected with a good interobserver reproducibility (kappa coefficient: 0.75). The SI in the myocardium of myocarditis patients was increased compared with controls (1.08 ± 0.03 vs 0.945 ± 0.04, p = 0.03) and the SI in myocarditis patients with hyperemia compared with those without hyperemia (1.22 ± 0.04 vs 0.94 ± 0.04, p <0.0001). Sensitivity, specificity, positive predictive, and negative predictive values of FPP for detecting hyperemia were 85%, 94%, 85%, and 93%, respectively. In conclusion, contrast-enhanced first-pass magnetic resonance imaging is a fast and useful method for assessing myocardial hyperemia in patients with acute myocarditis.


Asunto(s)
Hiperemia/diagnóstico por imagen , Miocarditis/diagnóstico por imagen , Pericardio/diagnóstico por imagen , Enfermedad Aguda , Adulto , Medios de Contraste , Femenino , Compuestos Heterocíclicos , Humanos , Imagen por Resonancia Magnética , Imagen por Resonancia Cinemagnética , Masculino , Persona de Mediana Edad , Imagen de Perfusión Miocárdica , Compuestos Organometálicos , Reproducibilidad de los Resultados , Estudios Retrospectivos
12.
Magn Reson Imaging ; 23(9): 929-37, 2005 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-16310108

RESUMEN

Our purpose was to investigate leukoaraïosis (LA) using three-dimensional MR imaging combined with advanced image-processing technology to attempt to group signal abnormalities according to their etiology. Coronal T2-weighted fast fluid-attenuated inversion-recovery (FLAIR) sequences and three-dimensional T1-weighted fast spoiled gradient recalled echo sequences were used to examine cerebral white matter changes in 75 elderly people with memory complaint but no dementia. They were otherwise healthy, community-dwelling subjects. Three subtypes of LA were defined on the basis of their shape, geography and extent: the so-called subependymal/subpial LA, perivascular LA and "bands" along long white matter tracts. Subependymal changes were directly contiguous with ventricular spaces. They showed features of "water hammer" lesions with ventricular systematisation and a more frequent location around the frontal horns than around the bodies (P=.0008). The use of cerebrospinal fluid (CSF) contiguity criterion allowed a classification of splenial changes in the subpial group. Conversely, posterior periventricular lesions in the centrum ovale as well as irregular and extensive periventricular lesions were not directly contiguous with CSF spaces. The so-called perivascular changes showed features of small-vessel-associated disease; they surrounded linear CSF-like signals that followed the direction of perforating vessels. Distribution of these perivascular changes appeared heterogeneous (P ranging from .04 to 5.10(-16)). These findings suggest that subependymal/subpial LA and subcortical LA may be separate manifestations of a single underlying pulse-wave encephalopathy.


Asunto(s)
Envejecimiento/fisiología , Imagenología Tridimensional , Leucoaraiosis/patología , Imagen por Resonancia Magnética/métodos , Trastornos de la Memoria/patología , Anciano , Anciano de 80 o más Años , Distribución de Chi-Cuadrado , Humanos , Procesamiento de Imagen Asistido por Computador , Persona de Mediana Edad
15.
Int J Cardiol ; 184: 22-27, 2015 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-25705006

RESUMEN

BACKGROUND: Contrast-enhanced computed tomography (CT) is routinely used as a complementary technique to trans-thoracic echocardiography (TTE) for assessing thoracic aortic aneurysms (TAA). However different measures can be obtained on CT and there are no recommendations on which to use. The objective was to determine which CT measurements most closely match reference TTE measurements in Marfan patients with TAA. METHODS: TTE measurements were obtained using the leading edge-to-leading edge technique in end-diastole on the parasternal longitudinal view. ECG-gated CT measurements were obtained, using the inner-to-inner technique in end-diastole by double oblique reconstruction: on three-cavity view (3C), left ventricle-aorta view (LVAo), and strict transverse plane passing through the maximal diameter "cusp to commissure" and "cusp to cusp" for each cusp. CT and TTE were performed within one month. RESULTS: 44 Marfan patients (39 ± 19 years, 48% men) were included. Dilatation of the ascending aorta was maximal at the level of the sinuses (TTE diameters: mean 47.5 ± 5.3 mm). TTE diameters were similar to 3C, LVAo (mean differences: 2.2 and -0.1 mm, p=NS) and to the three "cusp to cusp" diameters (mean differences ranging from 0 to 1.1mm, p=NS), whereas "cusp to commissure" diameters were all statistically smaller than TTE (3.6 mm, 2.9 mm and 3.7 mm, p ≤ 0.01). CONCLUSIONS: Inner-to-inner "cusp to cusp" diameter measured on an ECG-gated CT should be used for comparison with 2D TTE aortic diameter at the level of the sinuses of Valsalva in patients with thoracic aortic aneurysms.


Asunto(s)
Aneurisma de la Aorta/diagnóstico , Angiografía Coronaria , Ecocardiografía , Electrocardiografía , Síndrome de Marfan/diagnóstico , Tomografía Computarizada por Rayos X , Adulto , Aorta/diagnóstico por imagen , Aneurisma de la Aorta/epidemiología , Aneurisma de la Aorta/fisiopatología , Aortografía/normas , Angiografía Coronaria/normas , Ecocardiografía/normas , Electrocardiografía/normas , Femenino , Estudios de Seguimiento , Humanos , Masculino , Síndrome de Marfan/epidemiología , Síndrome de Marfan/fisiopatología , Persona de Mediana Edad , Tomografía Computarizada por Rayos X/normas , Adulto Joven
16.
Invest Radiol ; 39(1): 45-55, 2004 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-14701988

RESUMEN

RATIONALE AND OBJECTIVES: Using magnetic resonance imaging (MRI), we investigated cerebral blood and cerebrospinal fluid (CSF) flows in patients with communicating hydrocephalus (CH) and in healthy volunteers to determine the contribution of CSF flow to brain pressure regulation in CH patients. METHODS: Cine phase-contrast MRI data from 16 healthy volunteers and 12 patients with CH characterized by hyperdynamic aqueductal CSF flow were analyzed using in-house image-processing software that automatically measured flow curves. Amplitude and temporal CSF and blood flow parameters were compared in the 2 groups. RESULTS: Jugular peak flow occurred significantly earlier (P < 0.01) in the CH patients than in the healthy volunteers. Cervical CSF oscillations were not significantly different between the 2 groups. CONCLUSION: Venous vessel compression and/or changes in intracranial subarachnoid CSF flow produce an increase in ventricular CSF flush that compensates for vascular brain expansion in patients with CH.


Asunto(s)
Líquido Cefalorraquídeo/fisiología , Circulación Cerebrovascular/fisiología , Hidrocefalia/fisiopatología , Imagen por Resonancia Cinemagnética , Adolescente , Adulto , Velocidad del Flujo Sanguíneo/fisiología , Presión del Líquido Cefalorraquídeo , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador , Presión Intracraneal , Masculino , Factores de Tiempo
17.
Curr Aging Sci ; 5(2): 157-67, 2012 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-22894741

RESUMEN

The recent concept of pulse wave encephalopathy helps understanding the cerebral venous remodeling in aging. This so-called periventricular venous collagenosis is an expected mechanical consequence of the age-related changes in arterial pulsations and the mechanical fatigue of vascular smooth muscles. Unlike arteriolar mechanical stress, venular mechanical stress depends on both the blood pulse wave amplitude and the mechanical properties of the environment tissue. Thereby, there is a preferential periventricular location of venous collagenosis and a mechanistic link between venous collagenosis and foci of white matter rarefaction or leukoaraiosis. The recent concept of pulse wave encephalopathy also helps understanding the widening of retinal venules, the "mirror" of cerebral venules, in various manifestations of pulse wave encephalopathy, including progressive leukoara�osis, lacunar and hemorrhagic "pulse wave" strokes, and dementia. Indeed, the age-related chronic increase in arterial pulsations explains subsequent arteriolar myogenic "fatigue", marked attenuation in the arteriolar myogenic tone and abnormal penetration of the insufficiently dampened arterial pulse wave into the venules. Thus, retinal venular widening, a biomarker of advanced pulse wave encephalopathy, is also increasingly recognized as a biomarker for high cardiovascular risk. All these data support a shift in the concept of chronic cerebrovascular disease, from the classical model which is restricted to steno-occlusive cerebrovascular diseases to an enlarged model which would include the pulse wave encephalopathy concept. Thereby, preventing damage to the cerebral microvasculature by an undampened arterial pulse wave will become a logical target for the prevention and treatment of late-onset cognitive decline.


Asunto(s)
Envejecimiento/patología , Encéfalo/irrigación sanguínea , Capilares/patología , Venas Cerebrales/patología , Circulación Cerebrovascular , Trastornos Cerebrovasculares/patología , Enfermedades del Colágeno/patología , Flujo Pulsátil , Factores de Edad , Envejecimiento/psicología , Animales , Presión Arterial , Capilares/fisiopatología , Venas Cerebrales/fisiopatología , Trastornos Cerebrovasculares/etiología , Trastornos Cerebrovasculares/fisiopatología , Trastornos Cerebrovasculares/psicología , Enfermedad Crónica , Cognición , Enfermedades del Colágeno/etiología , Enfermedades del Colágeno/fisiopatología , Enfermedades del Colágeno/psicología , Dilatación Patológica , Elasticidad , Humanos , Análisis de la Onda del Pulso , Estrés Mecánico
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