[Neurophysiological methods for predicting outcome in cases of spine and spinal cord injury]. / Neirofiziologicheskie metody prognozirovaniya iskhoda pozvonochno-spinnomozgovoi travmy.

The purpose of the review was to determine the capabilities of neurophysiological examination for predicting the outcome of spinal injury. We have analyzed the methods of neurophysiological examination of spinal cord function and the role of these data in prediction of functional recovery in patients with complicated vertebral-spinal injury. Application of functional diagnostic methods for spinal shock was also considered.

[A newly-discovered deposit of sea-silt sulfide therapeutic muds in Primoskii Krai].

A new rich deposit of sea-silt sulfide muds (Melkovodnenskoye) have recently been found on Island Russky, Primosky krai (territory). A comprehensive survey of bottom sediments in the Melkovodnaya (Voevoda) Bay was undertaken to map out the underwater landscape, calculate mud reserves, investigate physico-chemical, radiological, bacteriological, and microbial composition of the mud. Results of experimental and clinical studies give reason to recommend sea-silt sulfide muds of the Melkovodnenskoye deposit for therapeutic and preventive use not only by the sick but also by healthy subjects. In either group, they may exert beneficial effect by stimulating preventive and compensatory reactions of the organism, activating the immune system, preventing undesirable metabolic changes, and suppressing inflammatory processes.

[The composition of nonesterified fatty acids in patients with metabolic syndrome].

The blood composition of non-etherized fatty acids (NEFA) was studied in 22 patients with metabolic syndrome (MS) and 11 healthy individuals. The qualitative NEFA composition presented by 31 components of individual fatty acids was analyzed, by taking into account of glucose-insulin homeostatic changes in MS patients: those without insulin resistance (IR) (Group 1) and those with diagnosed IR (Group 2). MS patients with normal insulinemia were ascertained to have lower levels of lauric, myristic, palmitic, C24:0, C16:0i acids. With a decrease in the relative quantity of saturated NEFA, the levels of polyunsaturated fatty acids (FA) increased. The proportions of linoleic (C18:2 omega 6) and linolenic (C18:3 omega 3) acids doubled (p < 0.01), arachidonic acid (C20:4 omega 6) was observed to tend to rise. The cumulative FA index sigma omega 6 increased twofold. In Group 1, the integrated index of changes in the FA series (unsaturation index) was 41% higher than that in the control group (p < 0.05). In Group 2, the vector of changes in the relative quantity of NEFA was similar, but impairments were less marked than that in Group 1. The findings suggest that the development of insulin resistance is preceded by impaired blood cell transfer and absorption of NEFA.

[Metabolic disorders in patients with chronic obstructive pulmonary disease].

AIM: To characterize cell dysregulation in chronic obstructive pulmonary disease (COPD) at local and systemic levels. MATERIAL AND METHODS: A total of 48 patients with COPD were examined (mean disease duration 11.2 +/- 7.2 years, mean age 58 +/- 4.2 years). Content of glutathione, and activity of glutathione peroxidase, glutathione reductase in whole blood (Novgorodtseva T.P., 2003), catalase in erythrocytes (Karpichenko A.I., 1999) were determined. Products of lipid peroxidation in exhaled breath condensate were defined to reveal diene conjugates of hydroperoxides, ketodienes, coupled trienes (Khyshiktuyev B.S., 1996). RESULTS: An evident oxidation stress at the local level was revealed in patients with COPD in deficiency of enzymatic antiperoxide link of anti-oxidant defense that is characterized by increased quantity of lipid peroxidation intermediants both in heptane and isopropanol phases.

[Medical aspects of migration in the Far East regions]. / Meditsinskie aspekty migratsionnykh protsessov v Dalnevostochnom regione.

A comparative analysis was made of medical and climatic conditions in the south of the Far East. Changes in the immune status, lipid peroxidation of blood cell membranes, and the antioxidative system were studied during adaptation of adults and children who had arrived from Siberia, the European part of Russia, and Far-East regions. How a standard regional adaptation of the bioimmunological status forms was followed up under the conditions of monsoons. Critical periods in migrants' adaptation and bioimmunological criteria of development of disadaptation conditions are described. A concept of the tense-dynamic type of migrants' adaptative bioimmunological reactions under the Far East monsoon conditions is proposed.

[The lipid component of the erythrocytes in young men in the symptom-free stages of ischemic heart disease]. / Lipidnaia komponenta éritrotsitov krovi molodykh muzhchin na bessimptomnykh stadiiakh ishemicheskoi bolezni serdtsa.

The paper presents the results of investigations of primary disturbances in the composition of phospholipids (PLs) and fatty acids (FAs) of erythrocytic lipids in young males at the preclinical stage of coronary heart disease (CHD). One hundred and twenty-nine males were examined. The examines were divided into three groups: (1) healthy subjects without CHD risk factors; (2) patients with prior myocardial infarction and (3) subjects suspected for CHD risk factors (aggravated hereditary and/or smoking). Primary signs of disturbances in the erythrocytic lipid component in Group 3 subjects. The differences in the levels of some PLs, individual FAs and FA families were found to correspond to the disturbances in Group 2 patients, but they were less profound. The changes in the composition of FA in Group 3 males suggest lipid metabolic disturbances, which is a risk factor for CHD.

[Post-clinical period of disease: metabolic aspects]. / Metabolicheskie aspekty posleklinicheskogo perioda bolezni.

Examining the biochemical processes in the rehabilitative period after diseases of vascular and inflammatory genesis showed it expedient to identify an asymptomatic postclinical period of disease as an independent stage of metabolic remission. The guideline for assessing the completeness of metabolic processes was to study such indices reflecting the nonspecific pathological and etiological essence of diseases as erythrocytic phospholipids and fatty acids, as well as indices of the lipid peroxidation-antioxidative defense system, a lysosomal enzyme beta-glucosidase, uric acid and hydroxyproline. The duration of an asymptomatic postclinical stage was found to be determined by the time of completeness of metabolic processes and to be 3-12 months after the onset of clinical recovery.

[The phospholipid spectrum of the blood serum in patients with chronic non-specific pulmonary diseases during rehabilitation treatment]. / Fosfolipidnyi spektr syvorotki krovi bol'nykh khronicheskimi nespetsificheskimi zabolevaniiami legkikh v protsesse vosstanovitel'nogo lecheniia.

Lipid metabolism was studied in 49 patients with chronic non-specific pulmonary diseases. The judgement about lipid metabolism was formed on the basis of changes in the content of phospholipid (PL) fractions in the patients' blood serum under the influence of health resort treatment. PL were separated by micro-thin-layer chromatography. They included five fractions: phosphatidylcholine (PC), sphingomyelin (SM), lysophosphatidylcholine (LPC), phosphatidylethanolamine (PE) and phosphatidylinositol (PI). The patients with chronic non-specific pulmonary diseases showed a significant decrease in the PC level and a rise of SM, LPC and PI. In the course of health resort treatment, lipid metabolism in the patients did not return to normal. The tendency towards normalization was observed only by the sixth month after rehabilitation treatment. The changes discovered are of diagnostic importance and can be used in the assessment of the efficacy of health resort treatment aimed at the removal of the inflammatory process in the lungs.

[Use of autotransfusion of UV-irradiated blood in chronic bronchitis]. / Primenenie autotransfuzii obluchennoi ul'trafioletom krovi pri khronicheskom bronkhite.

Effectiveness of rehabilitation with therapeutic complex based on autotransfusion of UV-radiated blood (ATUVRB) was studied in 81 patients with chronic bronchitis (CB). The course consisted of 5 procedures with interval 2-3 days. The first procedure was exploratory with irradiated blood 0.5-0.8 ml/kg body weight. Control group comprised 48 CB patients getting conventional complex of rehabilitation measures. As shown by clinical criteria, clinico-biochemical indices, immunograms, external respiration function, ATUVRB-based rehabilitation corrects main pathogenetic mechanisms of CB.

[Principles of rehabilitation of respiratory tract diseases]. / Printsipy vosstanovitel'nogo lecheniia bolezne organov dykhaniia.

The authors propose a conception of rehabilitation after respiratory diseases based on combined action of some nonpharmacological therapeutic factors operating etiologically, symptomatically, pathogenetically and sanogenetically. These rehabilitation methods can be used in persons with respiratory diseases risk factors and for prophylaxis.

[The potentials for the balneotherapy of obesity using arsenic-containing mineral water]. / Vozmozhnosti bal'neoterapii ozhireniia mysh'iaksoderzhashchei mineral'noi vodoi.

Arsenic mineral water from the Sinegorsk springs was tried in the treatment of experimental alimentary obesity in rat Wistar males and patients with exogenous-constitutional obesity. Body mass, blood lipids, hepatic neutral lipids, glucose-6-phosphate-dehydrogenase were measured. Arsenic mineral water proved able to reduce excessive body mass, correct blood lipid spectrum, normalize metabolic processes in the liver. Thus, arsenic mineral water can be used in balneotherapy of obesity.

[Sodium humate in the treatment of osteoarthrosis patients]. / Gumat natriia v lechenii bol'nykh osteoartrozom.

The authors' study of sodium humate balneotherapy in rehabilitation of osteoarthrosis patients has shown that such balneotherapy produces analgetic, antiinflammatory and lipid modulating effects, improves metabolic processes. Low concentration of the preparation and lack of effects of other mud factors make sodium humate procedures rather tolerable. Osteoarthrosis patients can apply the procedure in home setting.

[Pelotherapy in combined aftertreatment of patients with chronic bronchitis]. / Peloidoterapiia v kompleksnom vosstanovitel'nom lechenii bol'nykh khronicheskim bronkhitom.

A therapeutic complex based on pelotherapy given as mud applications or electrophoresis of squeezed mud on the area of lung root projection (a total of 10-12 procedures, each other day) was tested in 99 patients with chronic bronchitis (CB). 68 CB controls received the above complex but no peloids. The results were assessed by clinical changes, clinical biochemical indices, immunograms, changes in external respiration function. The pelotherapy was found to have a corrective effect on CB pathogenesis and a stimulating action on sanogenic mechanisms of the body.

[The modulating action of balneotherapy on the peroxidation processes in patients with ischemic heart disease]. / Moduliruiushchee deistvie bal'neoterapii na protsessy peroksidatsii u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The state of the system lipid peroxidation-antioxidant defense (LPO-AOD) was studied in 187 patients with ischemic heart disease on combined balneorehabilitation. The balneotherapy comprised effervescent magnesium-calcium and effervescent arsenic mineral water, artificial baths. Balneorehabilitation produced optimal results in high functional capacity of LPO-AOD system. In low functional activity of the system LPO-AOD balneological procedures may impair adaptive mechanisms and provoke balneoreactions. Combination of balneofactors with diet including polyunsaturated fatty acids enhanced antioxidant blood activity and modified LPO.

[Effect of the UV irradiation of autologous blood on the humoral link in the immune response of patients with chronic inflammatory processes]. / Vliianie UF-oblucheniia autokrovi na gumoral'noe zveno immunnogo otveta u bol'nykh s khronicheskimi vospalitel'nymi protsessami.

Autotransfusions of blood exposed to UV radiation for chronic inflammatory disease were found to normalize immunoglobulins (Ig) and immune complexes (IC) serum levels. A linear and invert correlations were revealed for large IC--IgG, IgM concentration, and small IC--IgM concentration, respectively.

[Ultraviolet irradiation of blood and peloid therapy (standard- and short-course) of patients with chronic bronchitis]. / Ul'trafioletovoe obluchenie krovi i peloidoterapiia (traditsionnye i ukorochennye kursy) bol'nykh khronicheskim bronkhitom.

Clinical symptoms, clinico-biochemical picture, immunograms and external respiration function were studied in 43 patients with chronic bronchitis undergoing UV blood radiation and peloid therapy. This treatment had a corrective effect on chronic bronchitis pathogenesis. Short courses of photon-peloid therapy showed the same effectiveness as routine ones at lower risk of side effects and higher cost efficiency.

[Dynamic microcirculatory disorders in patients with nonspecific lung diseases during the autotransfusion of ultraviolet-irradiated blood]. / Dinamika mikrotsirkuliatornykh narushenii u bol'nykh nespetsificheskimi zabolevaniiami legkikh v protsesse autotransfuzii ul'trafioletom obluchennoi krovi.

Consideration is given to time course changes in microcirculatory bed, hemostasis and fibrinolysis in patients with acute NPD and the trend of these changes upon autotransfusion of blood exposed to UV radiation. The doses of the blood varied. It was found that acute phase of the disease is characterized by impairment of hemostasis and fibrinolysis typical for DIC-syndrome. The autotransfusion promoted activation of fibrinolysis, hypocoagulation tendency, reduction of perivascular edema and sludge of red blood cells. Less beneficial effect was observed for the blood dose range of 1.5-2.0 ml/kg manifesting a transitory tendency to hypercoagulation and enhancement of erythrocytic sludge resulting in clinical aggravation in the middle of the treatment course. The highest response occurred in the dose range of 0.7-1.0 ml/kg which is proposed for management of NPD sufferers.

[The expansion of the indications for prescribing laser therapy in chronic recurrent dermatoses]. / O rasshirenii pokazanii k naznacheniiu lazernoi terapii pri khronicheskikh retsidiviruiushchikh dermatozakh.

Besides the well-known methods applied for the treatment of chronic recurrent dermatoses, the authors propose to use laser therapy for management of its coexistent diseases. The article contains data which prove the high efficiency of laser therapy for treatment of chronic recurrent dermatoses with such coexistent diseases as tonsillitis, hymoritis, gastroduodenal erosion, ulcers and respiratory diseases. Methods of laser therapy are enclosed.