Methicillin-resistant Staphylococcus aureus: decolonization and prevention prescribing practices for children treated with skin abscesses/boils in a pediatric emergency department.

OBJECTIVE: This study aimed to describe methicillin-resistant Staphylococcus aureus (MRSA) eradication/prevention practices of clinicians managing patients with skin and soft tissue infections (SSTIs), specifically, in those patients undergoing abscess incision and drainage (I&D) in a pediatric emergency department (ED). METHODS: A retrospective cohort study was performed for children aged 0 to 18 years old undergoing I&D of cutaneous abscess between January 1, 2011, and December 31, 2011, in the Cincinnati Children's Hospital Medical Center ED. RESULTS: Five hundred seventy-five patients underwent abscess I&D during our study period. Approximately 25% of our population had previous history of MRSA, SSTI, or boil/abscess; in addition, 26% of our population had a household family member with a previous history of MRSA, SSTI, or boil/abscess. Wound cultures were obtained in 399 (69%) of 575 of I&D abscesses, and of these, 57% of the I&D abscesses grew MRSA. Of all patients, only 3.7% (21 patients) had documentation of MRSA eradication/prevention instructions for patient/family. CONCLUSIONS: Methicillin-resistant S aureus eradication/prevention discussions are not commonly included in discharge instructions for patients undergoing abscess I&D. Given the significant proportion with previous MRSA infection, the ED may be a setting to provide instructions to patients/families with recurrent infections.

Elevated urinary leukotriene E4 levels are associated with hospitalization for pain in children with sickle cell disease.

Cysteinyl leukotrienes (CsyLTs) are inflammatory mediators produced by white blood cells. Leukotriene LTE(4) is the stable metabolite of CsyLTs, which can be measured in urine. We tested two hypotheses among children with sickle cell disease (SCD): (1) baseline urinary LTE(4) levels are elevated in children with SCD when compared with controls; and (2) baseline LTE(4) levels are associated with an increased incidence rate of hospitalization for SCD-related pain. Baseline LTE(4) levels were measured in children with SCD (cases) and children without SCD matched for age and ethnicity (controls). Medical records of cases were reviewed to assess the frequency of hospitalization for pain within 3 years of study entry. LTE(4) levels were obtained in 71 cases and 22 controls. LTE(4) levels were higher in cases compared with controls (median LTE(4): 100 vs. 57 pg/mg creatinine, P < 0.001). After adjustment for age and asthma diagnosis, a greater incidence rate of hospitalization for pain was observed among children with SCD in the highest LTE(4) tertile when compared with the lowest (114 vs. 52 episodes per 100 patient-years, P = 0.038). LTE(4) levels are elevated in children with SCD when compared with controls. LTE(4) levels are associated with an increased rate of hospitalizations for pain.

The resident decision-making process in global health education: appraising factors influencing participation.

The globalization of pediatric graduate medical education is ongoing; thus, this study was conducted to begin to explore the nature of resident interest in global health (GH) training and to further identify potentially modifiable factors influencing participation in away rotations. The authors surveyed all residents at Cincinnati Children's Hospital Medical Center to identify factors influencing participation in education efforts and away rotations. With a participation rate of 79.4% (n = 143), 5 key factors emerged as most significant in the decision-making process amid all participants. Among residents who had previous experience, 82.1% were interested in participating in an away elective compared with 58.3% of those without experience (P = .002). Residents with previous experience abroad were also more likely to plan to integrate GH into their careers (61.7% vs 26.7%, P < .0001). This article describes specific obstacles to resident participation in GH education and documents the association between previous experience and significant interest in long-term involvement.