Búsqueda | Portal de Búsqueda de la BVS

1.

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms.

Stein, Reed M; Kang, Hye Jin; McCorvy, John D; Glatfelter, Grant C; Jones, Anthony J; Che, Tao; Slocum, Samuel; Huang, Xi-Ping; Savych, Olena; Moroz, Yurii S; Stauch, Benjamin; Johansson, Linda C; Cherezov, Vadim; Kenakin, Terry; Irwin, John J; Shoichet, Brian K; Roth, Bryan L; Dubocovich, Margarita L.

Nature ; 579(7800): 609-614, 2020 03.

Artículo en Inglés | MEDLINE | ID: mdl-32040955

2.

Intracellular allosteric antagonist of the olfactory receptor OR51E2.

Abaffy, Tatjana; Fu, Olivia; Harume-Nagai, Maira; Goldenberg, Josh M; Kenyon, Victor; Kenakin, Terry.

Mol Pharmacol ; 2024 May 06.

Artículo en Inglés | MEDLINE | ID: mdl-38719475

3.

Allostery: The Good, the Bad, and the Ugly.

Kenakin, Terry.

J Pharmacol Exp Ther ; 388(1): 110-120, 2024 01 02.

Artículo en Inglés | MEDLINE | ID: mdl-37918859

4.

A Pharmacological perspective on the temporal properties of sweeteners.

Servant, Guy; Kenakin, Terry.

Pharmacol Res ; 204: 107211, 2024 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-38744400

5.

Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.

Krumm, Brian E; DiBerto, Jeffrey F; Olsen, Reid H J; Kang, Hye Jin; Slocum, Samuel T; Zhang, Shicheng; Strachan, Ryan T; Huang, Xi-Ping; Slosky, Lauren M; Pinkerton, Anthony B; Barak, Lawrence S; Caron, Marc G; Kenakin, Terry; Fay, Jonathan F; Roth, Bryan L.

Biochemistry ; 62(7): 1233-1248, 2023 04 04.

Artículo en Inglés | MEDLINE | ID: mdl-36917754

6.

Biased Receptor Signaling in Drug Discovery.

Kenakin, Terry.

Pharmacol Rev ; 71(2): 267-315, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-30914442

7.

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

Huang, Xi-Ping; Karpiak, Joel; Kroeze, Wesley K; Zhu, Hu; Chen, Xin; Moy, Sheryl S; Saddoris, Kara A; Nikolova, Viktoriya D; Farrell, Martilias S; Wang, Sheng; Mangano, Thomas J; Deshpande, Deepak A; Jiang, Alice; Penn, Raymond B; Jin, Jian; Koller, Beverly H; Kenakin, Terry; Shoichet, Brian K; Roth, Bryan L.

Nature ; 527(7579): 477-83, 2015 Nov 26.

Artículo en Inglés | MEDLINE | ID: mdl-26550826

8.

Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine.

Kaski, Shane W; White, Allison N; Gross, Joshua D; Trexler, Kristen R; Wix, Kim; Harland, Aubrie A; Prisinzano, Thomas E; Aubé, Jeffrey; Kinsey, Steven G; Kenakin, Terry; Siderovski, David P; Setola, Vincent.

J Pharmacol Exp Ther ; 371(2): 487-499, 2019 11.

Artículo en Inglés | MEDLINE | ID: mdl-31492823

9.

The pharmacologic characterization of allosteric molecules: Gq protein activation.

Bdioui, Sara; Verdi, Julien; Pierre, Nicolas; Trinquet, Eric; Roux, Thomas; Kenakin, Terry.

J Recept Signal Transduct Res ; 39(2): 106-113, 2019 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-31322035

10.

G-Protein/Receptor inhibitors as blockers of receptor signaling.

Kenakin, Terry.

J Theor Biol ; 480: 23-33, 2019 11 07.

Artículo en Inglés | MEDLINE | ID: mdl-31356763

11.

Theoretical Aspects of GPCR-Ligand Complex Pharmacology.

Kenakin, Terry.

Chem Rev ; 117(1): 4-20, 2017 01 11.

Artículo en Inglés | MEDLINE | ID: mdl-26856272

12.

Emergent Concepts of Receptor Pharmacology.

Kenakin, Terry.

Handb Exp Pharmacol ; 260: 17-41, 2019.

Artículo en Inglés | MEDLINE | ID: mdl-31768748

13.

Is the Quest for Signaling Bias Worth the Effort?

Kenakin, Terry.

Mol Pharmacol ; 93(4): 266-269, 2018 04.

Artículo en Inglés | MEDLINE | ID: mdl-29348268

14.

Equilibrium Assays Are Required to Accurately Characterize the Activity Profiles of Drugs Modulating Gq-Protein-Coupled Receptors.

Bdioui, Sara; Verdi, Julien; Pierre, Nicolas; Trinquet, Eric; Roux, Thomas; Kenakin, Terry.

Mol Pharmacol ; 94(3): 992-1006, 2018 09.

Artículo en Inglés | MEDLINE | ID: mdl-29954837

15.

N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias.

Soto, Antonio G; Smith, Thomas H; Chen, Buxin; Bhattacharya, Supriyo; Cordova, Isabel Canto; Kenakin, Terry; Vaidehi, Nagarajan; Trejo, JoAnn.

Proc Natl Acad Sci U S A ; 112(27): E3600-8, 2015 Jul 07.

Artículo en Inglés | MEDLINE | ID: mdl-26100877

16.

Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor.

Nguyen, Thuy; Li, Jun-Xu; Thomas, Brian F; Wiley, Jenny L; Kenakin, Terry P; Zhang, Yanan.

Med Res Rev ; 37(3): 441-474, 2017 05.

Artículo en Inglés | MEDLINE | ID: mdl-27879006

17.

A Scale of Agonism and Allosteric Modulation for Assessment of Selectivity, Bias, and Receptor Mutation.

Kenakin, Terry.

Mol Pharmacol ; 92(4): 414-424, 2017 10.

Artículo en Inglés | MEDLINE | ID: mdl-28679508

18.

A New Molecular Mechanism To Engineer Protean Agonism at a G Protein-Coupled Receptor.

De Min, Anna; Matera, Carlo; Bock, Andreas; Holze, Janine; Kloeckner, Jessica; Muth, Mathias; Traenkle, Christian; De Amici, Marco; Kenakin, Terry; Holzgrabe, Ulrike; Dallanoce, Clelia; Kostenis, Evi; Mohr, Klaus; Schrage, Ramona.

Mol Pharmacol ; 91(4): 348-356, 2017 04.

Artículo en Inglés | MEDLINE | ID: mdl-28167741

19.

Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT_2A Receptor Agonist.

Jensen, Anders A; McCorvy, John D; Leth-Petersen, Sebastian; Bundgaard, Christoffer; Liebscher, Gudrun; Kenakin, Terry P; Bräuner-Osborne, Hans; Kehler, Jan; Kristensen, Jesper Langgaard.

J Pharmacol Exp Ther ; 361(3): 441-453, 2017 06.

Artículo en Inglés | MEDLINE | ID: mdl-28360333

20.

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

Christopoulos, Arthur; Changeux, Jean-Pierre; Catterall, William A; Fabbro, Doriano; Burris, Thomas P; Cidlowski, John A; Olsen, Richard W; Peters, John A; Neubig, Richard R; Pin, Jean-Philippe; Sexton, Patrick M; Kenakin, Terry P; Ehlert, Frederick J; Spedding, Michael; Langmead, Christopher J.

Pharmacol Rev ; 66(4): 918-47, 2014 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-25026896

Portal de Búsqueda de la BVS

Información y Conocimiento para la Salud

Configurar filtros

Su selección (0)

Formato de exportación:

Exportar:

Virtual discovery of melatonin receptor ligands to modulate circadian rhythms.

Intracellular allosteric antagonist of the olfactory receptor OR51E2.

Allostery: The Good, the Bad, and the Ugly.

A Pharmacological perspective on the temporal properties of sweeteners.

Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.

Biased Receptor Signaling in Drug Discovery.

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine.

The pharmacologic characterization of allosteric molecules: Gq protein activation.

G-Protein/Receptor inhibitors as blockers of receptor signaling.

Theoretical Aspects of GPCR-Ligand Complex Pharmacology.

Emergent Concepts of Receptor Pharmacology.

Is the Quest for Signaling Bias Worth the Effort?

Equilibrium Assays Are Required to Accurately Characterize the Activity Profiles of Drugs Modulating Gq-Protein-Coupled Receptors.

N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias.

Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor.

A Scale of Agonism and Allosteric Modulation for Assessment of Selectivity, Bias, and Receptor Mutation.

A New Molecular Mechanism To Engineer Protean Agonism at a G Protein-Coupled Receptor.

Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT_2A Receptor Agonist.

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.