Functional hemispheric asymmetry in female prefrontal hemodynamics corresponding to changes in auditory sense during pregnancy and child raising.

We carried out further research into the prefrontal hemodynamics corresponding to changes in a women's auditory sense during pregnancy and child raising. A total of forty-six volunteers took part in our experiment, and we divided them into several groups in accordance with the progress of their child raising. For the auditory tasks performed by the volunteers, we used two auditory stimulations: the sound of baby crying, and a classical music as a control. Hemodynamic changes at the prefrontal regions were measured using a 2 ch functional near-infrared spectroscopy (fNIRS) along with a 47 ch fNIRS instrument equipped with 3×5 probes (22 ch). Judging the results of the female groups about their prefrontal hemodynamics, there were almost no significant differences across the groups in the dynamics with the music task. However, in the section of the baby crying task, their hemodynamics were regarded as significant compared to the control. Concerning the time scale of the changes in the hemodynamic response to the two tasks, especially in the postnatal group, we took notice of the possibility that higher activations were clearly observed at the right sides of their brains than their left sides. Our experimental results not only demonstrated that postnatal women within one and a half years of their childbearing might have acute ears, but also revealed the hemispheric asymmetry in their prefrontal hemodynamics, as compared to pregnant and nonpregnant volunteers. We inferred that the pregnancy-inducing expression of such women's special capabilities is definitely due to a boost-up of a built-in female disposition, which is destined for expressions of maternal love.

Fundamental study of functional changes to female brain induced by pregnancy and childbirth.

In this study, we investigated variations in a women's cognitive function during a time of pregnancy and childbearing. Volunteers were composed of 114 healthy women ranging in age from 23-43 years with an average age of 31.8 years (SD=4.3). Further, 79 were pregnant and 35 were not pregnant. All the pregnant women were expecting their first child and continued with the cognitive function analysis after their childbearing was concluded. We instructed the pregnant women to carry out five kinds of tests: simple reaction, SR; choice reaction, CR; working memory, WM; one card learning, OC; and divided attention, DA using card games through a cognitive function test called "CogHealth", and compared them to a nonpregnant group. In the results of the four measurement tasks (SR, CR, WM, and DA), there were no significant differences across the three groups in the responses with the tasks. However, the response times relating to the OC learning in the postnatal women were significantly smaller, as contrasted with the times for the pregnant and the nonpregnant women (F(2,144)=4.248, P <; 0.05). Furthermore, we compared their cognitive functions between pregnant and postnatal states in corresponding volunteers in the responses with the same tasks. We also demonstrated the fact that postnatal women responded more quickly to tasks in the OC (t(32)=2.95, P <; 0.01) and the WM (t(32)=3.03, P <; 0.01) categories than responses to performing the tasks during their pregnancy. Our findings support the idea that the functions of pregnant/postnatal women are not failing, or rather postnatal women are more responsive in their reaction times with their memories by 2.7-6.2%, than the responses in both pregnant and nonpregnant women.

Strong static magnetic field stimulates bone formation to a definite orientation in vitro and in vivo.

The induction of bone formation to an intentional orientation is a potentially viable clinical treatment for bone disorders. Among the many chemical and physical factors, a static magnetic field (SMF) of tesla order can regulate the shapes of blood cells and matrix fibers. This study investigated the effects of a strong SMF (8 T) on bone formation in both in vivo and in vitro systems. After 60 h of exposure to the SMF, cultured mouse osteoblastic MC3T3-E1 cells were transformed to rodlike shapes and were orientated in the direction parallel to the magnetic field. Although this strong SMF exposure did not affect cell proliferation, it up-regulated cell differentiation and matrix synthesis as determined by ALP and alizarin red stainings, respectively. The SMF also stimulated ectopic bone formation in and around subcutaneously implanted bone morphogenetic protein (BMP) 2-containing pellets in mice, in which the orientation of bone formation was parallel to the magnetic field. It is concluded that a strong SMF has the potency not only to stimulate bone formation, but also to regulate its orientation in both in vitro and in vivo models. This is the first study to show the regulation of the orientation of adherent cells by a magnetic field. We propose that the combination of a strong SMF and a potent osteogenic agent such as BMP possibly may lead to an effective treatment of bone fractures and defects.