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1.

Structure and Conformational Dynamics of the Human Spliceosomal B^act Complex.

Haselbach, David; Komarov, Ilya; Agafonov, Dmitry E; Hartmuth, Klaus; Graf, Benjamin; Dybkov, Olexandr; Urlaub, Henning; Kastner, Berthold; Lührmann, Reinhard; Stark, Holger.

Cell ; 172(3): 454-464.e11, 2018 01 25.

Artículo en Inglés | MEDLINE | ID: mdl-29361316

2.

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

Bertram, Karl; Agafonov, Dmitry E; Dybkov, Olexandr; Haselbach, David; Leelaram, Majety N; Will, Cindy L; Urlaub, Henning; Kastner, Berthold; Lührmann, Reinhard; Stark, Holger.

Cell ; 170(4): 701-713.e11, 2017 Aug 10.

Artículo en Inglés | MEDLINE | ID: mdl-28781166

3.

SnapShot: Spliceosome Dynamics II.

Wahl, Markus C; Lührmann, Reinhard.

Cell ; 162(2): 456-456.e1, 2015 Jul 16.

Artículo en Inglés | MEDLINE | ID: mdl-26186196

4.

SnapShot: Spliceosome Dynamics III.

Wahl, Markus C; Lührmann, Reinhard.

Cell ; 162(3): 690-690.e1, 2015 Jul 30.

Artículo en Inglés | MEDLINE | ID: mdl-26232231

5.

SnapShot: Spliceosome Dynamics I.

Wahl, Markus C; Lührmann, Reinhard.

Cell ; 161(6): 1474-e1, 2015 Jun 04.

Artículo en Inglés | MEDLINE | ID: mdl-26046445

6.

Structural insights into the cross-exon to cross-intron spliceosome switch.

Zhang, Zhenwei; Kumar, Vinay; Dybkov, Olexandr; Will, Cindy L; Zhong, Jiayun; Ludwig, Sebastian E J; Urlaub, Henning; Kastner, Berthold; Stark, Holger; Lührmann, Reinhard.

Nature ; 2024 May 22.

Artículo en Inglés | MEDLINE | ID: mdl-38778104

7.

Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins.

Zhang, Zhenwei; Kumar, Vinay; Dybkov, Olexandr; Will, Cindy L; Urlaub, Henning; Stark, Holger; Lührmann, Reinhard.

EMBO J ; 43(6): 1065-1088, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38383864

8.

Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome.

Bertram, Karl; El Ayoubi, Leyla; Dybkov, Olexandr; Agafonov, Dmitry E; Will, Cindy L; Hartmuth, Klaus; Urlaub, Henning; Kastner, Berthold; Stark, Holger; Lührmann, Reinhard.

Mol Cell ; 80(1): 127-139.e6, 2020 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-33007253

9.

Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription.

Cossa, Giacomo; Roeschert, Isabelle; Prinz, Florian; Baluapuri, Apoorva; Silveira Vidal, Raphael; Schülein-Völk, Christina; Chang, Yun-Chien; Ade, Carsten Patrick; Mastrobuoni, Guido; Girard, Cyrille; Wortmann, Lars; Walz, Susanne; Lührmann, Reinhard; Kempa, Stefan; Kuster, Bernhard; Wolf, Elmar; Mumberg, Dominik; Eilers, Martin.

Mol Cell ; 77(6): 1322-1339.e11, 2020 03 19.

Artículo en Inglés | MEDLINE | ID: mdl-32006464

10.

Structural insights into how Prp5 proofreads the pre-mRNA branch site.

Zhang, Zhenwei; Rigo, Norbert; Dybkov, Olexandr; Fourmann, Jean-Baptiste; Will, Cindy L; Kumar, Vinay; Urlaub, Henning; Stark, Holger; Lührmann, Reinhard.

Nature ; 596(7871): 296-300, 2021 08.

Artículo en Inglés | MEDLINE | ID: mdl-34349264

11.

Molecular architecture of the human 17S U2 snRNP.

Zhang, Zhenwei; Will, Cindy L; Bertram, Karl; Dybkov, Olexandr; Hartmuth, Klaus; Agafonov, Dmitry E; Hofele, Romina; Urlaub, Henning; Kastner, Berthold; Lührmann, Reinhard; Stark, Holger.

Nature ; 583(7815): 310-313, 2020 07.

Artículo en Inglés | MEDLINE | ID: mdl-32494006

12.

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.

Cretu, Constantin; Agrawal, Anant A; Cook, Andrew; Will, Cindy L; Fekkes, Peter; Smith, Peter G; Lührmann, Reinhard; Larsen, Nicholas; Buonamici, Silvia; Pena, Vladimir.

Mol Cell ; 70(2): 265-273.e8, 2018 04 19.

Artículo en Inglés | MEDLINE | ID: mdl-29656923

13.

Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors.

de Moura, Tales Rocha; Mozaffari-Jovin, Sina; Szabó, Csaba Zoltán Kibédi; Schmitzová, Jana; Dybkov, Olexandr; Cretu, Constantin; Kachala, Michael; Svergun, Dmitri; Urlaub, Henning; Lührmann, Reinhard; Pena, Vladimir.

Mol Cell ; 69(6): 979-992.e6, 2018 03 15.

Artículo en Inglés | MEDLINE | ID: mdl-29547724

14.

The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated B^act complex.

Bao, Penghui; Will, Cindy L; Urlaub, Henning; Boon, Kum-Loong; Lührmann, Reinhard.

Genes Dev ; 31(23-24): 2416-2429, 2017 12 01.

Artículo en Inglés | MEDLINE | ID: mdl-29330354

15.

The spliceosome: design principles of a dynamic RNP machine.

Wahl, Markus C; Will, Cindy L; Lührmann, Reinhard.

Cell ; 136(4): 701-18, 2009 Feb 20.

Artículo en Inglés | MEDLINE | ID: mdl-19239890

16.

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.

Cretu, Constantin; Schmitzová, Jana; Ponce-Salvatierra, Almudena; Dybkov, Olexandr; De Laurentiis, Evelina I; Sharma, Kundan; Will, Cindy L; Urlaub, Henning; Lührmann, Reinhard; Pena, Vladimir.

Mol Cell ; 64(2): 307-319, 2016 10 20.

Artículo en Inglés | MEDLINE | ID: mdl-27720643

17.

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.

Cossa, Giacomo; Roeschert, Isabelle; Prinz, Florian; Baluapuri, Apoorva; Vidal, Raphael Silveira; Schülein-Völk, Christina; Chang, Yun-Chien; Ade, Carsten Patrick; Mastrobuoni, Guido; Girard, Cyrille; Kumar, Amit; Wortmann, Lars; Walz, Susanne; Lührmann, Reinhard; Kempa, Stefan; Kuster, Bernhard; Wolf, Elmar; Mumberg, Dominik; Eilers, Martin.

Mol Cell ; 81(11): 2495, 2021 Jun 03.

Artículo en Inglés | MEDLINE | ID: mdl-34087181

18.

Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competition.

Yu, Yang; Maroney, Patricia A; Denker, John A; Zhang, Xiang H-F; Dybkov, Olexandr; Lührmann, Reinhard; Jankowsky, Eckhard; Chasin, Lawrence A; Nilsen, Timothy W.

Cell ; 135(7): 1224-36, 2008 Dec 26.

Artículo en Inglés | MEDLINE | ID: mdl-19109894

19.

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

Bertram, Karl; Agafonov, Dmitry E; Liu, Wen-Ti; Dybkov, Olexandr; Will, Cindy L; Hartmuth, Klaus; Urlaub, Henning; Kastner, Berthold; Stark, Holger; Lührmann, Reinhard.

Nature ; 542(7641): 318-323, 2017 02 16.

Artículo en Inglés | MEDLINE | ID: mdl-28076346

20.

SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes.

Yildirim, Adem; Mozaffari-Jovin, Sina; Wallisch, Ann-Kathrin; Schäfer, Jessica; Ludwig, Sebastian E J; Urlaub, Henning; Lührmann, Reinhard; Wolfrum, Uwe.

Nucleic Acids Res ; 49(10): 5845-5866, 2021 06 04.

Artículo en Inglés | MEDLINE | ID: mdl-34023904

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Structure and Conformational Dynamics of the Human Spliceosomal B^act Complex.

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

SnapShot: Spliceosome Dynamics II.

SnapShot: Spliceosome Dynamics III.

SnapShot: Spliceosome Dynamics I.

Structural insights into the cross-exon to cross-intron spliceosome switch.

Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins.

Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome.

Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription.

Structural insights into how Prp5 proofreads the pre-mRNA branch site.

Molecular architecture of the human 17S U2 snRNP.

Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.

Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors.

The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated B^act complex.

The spliceosome: design principles of a dynamic RNP machine.

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.

Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competition.

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes.