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Under the theoretical guidance of "combination of disease and syndromeï¼ correspondence between syndrome and prescriptionï¼ and dynamic space-time"ï¼ 11 135 acute ischemic stroke patients were collected from hospital information system(HIS) of many 3A grade hospitals of traditional Chinese medicine. Complex network analysis was adopted to obtain the core syndrome elements in different periods of acute ischemic stroke patientsï¼ and it was found that the core syndrome elements were blood stasis syndromeï¼ phlegmï¼ endogenous windï¼ Yin deficiencyï¼ Qi deficiencyï¼ heatï¼ hyperactivity of liver Yangï¼ liverï¼ and kidney of patients in hospital for the first dayï¼ and during 8-14 d in hospitalizationï¼ the core syndrome elements were blood stasisï¼ phlegmï¼ Yin deficiencyï¼ Qi deficiencyï¼ endogenous windï¼ hyperactivity of liver Yangï¼ liverï¼ and kidney. The data with "improved" and "cured" treatment outcomes were adopted for complex network analysis and correlation analysis to identify the Chinese and Western medicine group modules in patients with different disease conditions in different phases after hospitalization. It was found that the Chinese and Western medicine modules within 14 d after hospitalization mainly included "blood-activating and stasis-dissolving module "consisted by "anti-platelet drug + circulation-improving medicine(or anticoagulant drug and anti-fibrinogen drugï¼ et al) + blood-activating and stasis-dissolving drugs"ï¼ as well as "stasis-dissolving and phlegm-reducing module" consisted by "anti-platelet drugs + circulation-improving medicine(or anticoagulant drug and anti-fibrinogen drugï¼ et al) + phlegm refreshing drug". The core Chinese and Western medicine modules in patients with urgent and general conditions within 7 d after hospitalization mainly used "blood-activating and stasis-dissolving module" and "stasis-dissolving and phlegm-reducing module". Three or more Chinese medicine and Western medicines module with more than 1% utilization rate was not found in the patients with critical disease condition in admission. The urgentï¼ general and critically ill patients in admission mainly used "blood-activating and stasis-dissolving module" in 8-14 d. From the real world medical big data researchï¼ it was found that the combined use of Chinese and Western medicines were consistent with "combination of disease and syndromeï¼ correspondence between syndrome and prescriptionï¼ and dynamic space-time" theoryï¼ and multiple multidimensional dynamic Chinese medicine and Western medicine group modules of "patient-syndrome-drug-time-effective" at the acute ischemic stroke stage were dug outï¼ forming the method of Chinese and Western medicine combination research based on electrical medical big data.
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Isquemia Encefálica/diagnóstico , Isquemia Encefálica/terapia , Medicina Tradicional China , Accidente Cerebrovascular/diagnóstico , Accidente Cerebrovascular/terapia , Humanos , Síndrome , Deficiencia YinRESUMEN
In order to obtain the characteristics and incidence of adverse reactions of Shuxuening injection (Xingxue), the design method of a multi-center, large sample intensive monitoring in the hospitals was adopted. The hospitalized patients with use of Shuxuening injection from 27 medical institutions were enrolled as the research subjects to monitor their entire process of treatment cycle. The main content of monitoring included the patients' general information, diagnostic information, medication information, and adverse event information. A total of 30 209 patients with Shuxuening injection were enrolled; adverse reactions occurred in 34 cases, with an incidence of 0.113%, which belonged to the rare adverse reactions. Adverse reactions were characterized by headache, dizziness, pruritus, palpitations, nausea, et al. All the above results showed that Xingxue Shuxuening injection had high safety in clinical application.
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Medicamentos Herbarios Chinos/efectos adversos , Vigilancia de Productos Comercializados , Humanos , InyeccionesRESUMEN
To systematically review the incidence rate of adverse drug reaction/event by Qingkailing injection. Such databases as the PubMed, EMbase, the Cochrane library, CNKI, VIP WanFang data and CBM were searched by computer from foundation to July 30, 2015. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data and cross check data. Then, Meta-analysis was performed by using the R 3.2.0 software, subgroup sensitivity analysis was performed based on age, mode of medicine, observation time and research quality. Sixty-three studies involving 9,793 patients with Qingkailing injection were included, 367 cases of adverse reactions/events were reported in total. The incidence rate of adverse reaction in skin and mucosa group was 2% [95% CI (0.02; 0.03)]; the digestive system adverse reaction was 6% [95% CI(0.05; 0.07); the injection site adverse reaction was 4% [95% CI (0.02; 0.07)]. In the digestive system as the main types of adverse reactions/events, incidence of children and adults were 4.6% [0.021 1; 0.097 7] and 6.9% [0.053 5; 0.089 8], respectively. Adverse reactions to skin and mucous membrane damage as the main performance/event type, the observation time > 7 days and ≤ 7 days incidence of 3% [0.012 9; 0.068 3] and 1.9% [0.007 8; 0.046 1], respectively. Subgroup analysis showed that different types of adverse reactions, combination in the incidence of adverse reactions/events were higher than that of single drug, the difference was statistically significant (P < 0.05). This study suggested the influence factors of adverse reactions occur, and clinical rational drug use, such as combination, age and other fators, and the influence factors vary in different populations. Therefore, clinical doctors for children and the elderly use special care was required for a clear and open spirit injection, the implementation of individualized medication.
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Medicamentos Herbarios Chinos/efectos adversos , Adolescente , Adulto , Anciano , Niño , Preescolar , Femenino , Humanos , Incidencia , Lactante , Recién Nacido , Inyecciones , Masculino , Persona de Mediana EdadRESUMEN
The regulations on basic clinical use of parenterally administered Chinese medicine, issued jointly in 2008, by the ministry of health (MOH), China food and drug administration (SFDA) and the state administration of traditional Chinese medicine (SATCM). Integrating actual clinical practice, these presented doctors and nurses with detailed specifications for the safe use of parenterally administered Chinese medicine. The regulations emphasize the use of Chinese medicine pattern differentiation, use in strict accordance with instructions, and they prohibit use combined with other medicines. The emphasis of the regulations are practicality and operability, and provide meaningful guidance to doctors and nurses for the rational and safe use of parenterally administered Chinese medicine, to reduce adverse reactions/adverse events caused by improper use.
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Quimioterapia/normas , Medicamentos Herbarios Chinos/normas , China , Medicamentos Herbarios Chinos/administración & dosificación , Guías como Asunto , Humanos , Infusiones ParenteralesRESUMEN
It is of vital significance to conduct active post-marketing surveillance of Chinese medicine, as an active response to laws, rules and guidelines issued by the China food and drug administration. The standards for technological specifications based on expert consensus have been drafted. These will provide technological support in evaluating adverse drug reactions (ADRs) or adverse drug events (ADEs). The technological specifications for post-marketing surveillance focus on two surveillance designs; one is a large sample registry study to explore general population ADR/ADE characteristics, the other is a nested case-control study to explore the characteristic and mechanisms of ADRs.
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Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/epidemiología , Medicamentos Herbarios Chinos/normas , Vigilancia de Productos Comercializados/normas , China/epidemiología , Monitoreo de Drogas/efectos adversos , Monitoreo de Drogas/normas , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos/etiología , Medicamentos Herbarios Chinos/efectos adversos , Sistemas de Información en Hospital , Humanos , Vigilancia de Productos Comercializados/métodosRESUMEN
Shuxuetong injection is a kind of compound injection which is made from traditional Chinese medicine Hirudo and Pheretime, which has a clear anticoagulant, fibrinolytic promoting, blood rheology improving, blood lipids regulating and cell protecting effect, and the injection has been widely used in clinical. Especially, the injection has often been combined with other Chinese and modern medicine in the treatment of cerebral infarction disease. However, there are still many non-standard and irrational aspects in clinical practice so as to make a more reasonable and safer use of Shuxuetong injection. In order to avoid the occurrence of adverse reactions to provide a reference for regulating the use of the injection,the paper systematically expounds the Shuxuetong injection's main clinical problems and the reasonable combination.
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Infarto Cerebral/tratamiento farmacológico , Medicamentos Herbarios Chinos/administración & dosificación , Administración Intravenosa , Animales , Anélidos , Medicamentos Herbarios Chinos/efectos adversos , HumanosRESUMEN
Currently, there are many traditional Chinese medicine (TCM) injections for treating ischemic stroke in the market, most of them have the efficacy of promoting blood circulation and removing blood stasis, but their reasonable applications are worth consideration. From the angles of traditional Chinese medicine and modern medicine, TCM injections that are commonly used in clinics were detected for their indications and pharmacological effects, compared in terms of their characteristics of clinical application, precautions, prohibition on use, caution and adverse reactions and categorized, in order to help clinicians with reasonable application of TCM injections.
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Circulación Sanguínea/efectos de los fármacos , Trastornos Cerebrovasculares/tratamiento farmacológico , Medicamentos Herbarios Chinos/administración & dosificación , Trastornos Cerebrovasculares/fisiopatología , Humanos , InyeccionesRESUMEN
BACKGROUND: Madelung's disease (MD) is a rare disorder of lipid metabolism, characterized by the growth of unencapsulated masses of adipose tissue symmetrically deposited around the neck, shoulders, or other sites around the body. Its pathological mechanism is not yet known. One of the most common comorbidities in MD patients is liver disease, especially chronic alcoholic liver disease (CALD); however, no reports exist of acute kidney injury (AKI) with MD. CASE SUMMARY: We report a 60-year-old man who presented with complaint of edema in the lower limbs that had persisted for 3 d. Physical examination showed subcutaneous masses around the neck, and history-taking revealed the masses to have been present for 2 years and long-term heavy drinking. Considering the clinical symptoms, along with various laboratory test results and imaging characteristics, a diagnosis was made of MD with acute exacerbation of CALD and AKI. The patient was treated with liver function protection and traditional Chinese medicine, without surgical intervention. He was advised to quit drinking. After 10 d, the edema had subsided, renal function indicators returned to normal, liver function significantly improved, and size of subcutaneous masses remained stable. CONCLUSION: In MD, concomitant liver or kidney complications are possible and monitoring of liver and kidney functions can be beneficial.
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OBJECTIVE: To determine the association between levels of basic metabolic elements and degeneration and ossification of the ligamentum flavum (LF). SUBJECTS: Fourteen consecutive patients with degenerative lumbar stenosis, 11 with ossification of the thoracic ligamenta flava, and 11 control subjects. METHODS: The basic elements of calcium (Ca), phosphorus (P), magnesium (Mg), zinc (Zn), copper (Cu), manganese (Mn), molybdenum (Mo), and fluoride (F) in the specimens were measured using atomic absorption spectrometry, the phosphomolybdic blue method, and a fluoride-selected electrode. RESULTS: Ca content and the ratio of Ca/Mg in the LF specimens increased significantly in the sequence of control, degeneration, and ossification groups. Compared with values for the control group, the Zn, Mn, and Mo contents in the ossification and degeneration groups were significantly lower (P < 0.01); in contrast, Cu content was significantly higher (P < 0.01). As to F, its content in the specimens of the ossification group was much higher than those in the degeneration and control groups (P < 0.01); the F content in the ligamenta flava and sera from patients with fluorosis was also significantly higher than in those from patients without fluorosis (P < 0.01). Compared with the control group, there were no differences in the F content in serum from patients without fluorosis; however, the F content in ligamenta flava specimens from patients without fluorosis was significantly higher (P < 0.01). CONCLUSIONS: There are trends in the contents of basic metabolic elements in the degeneration and ossification of ligamenta flava. These basic metabolic elements may play an important role in this process.
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Elementos Químicos , Ligamento Amarillo/metabolismo , Osificación Heterotópica/metabolismo , Osificación Heterotópica/patología , Osteonecrosis/metabolismo , Adulto , Estudios de Casos y Controles , Femenino , Fluoruros/metabolismo , Humanos , Masculino , Manganeso/metabolismo , Persona de Mediana Edad , Fósforo/metabolismo , Estudios Retrospectivos , Espectrofotometría Atómica/métodos , Zinc/metabolismoRESUMEN
PURPOSE: To determine the indications and benefits of ectopic implantation in the salvage of amputated thumb. BASIC PROCEDURES: Two cases of avulsed amputated thumbs were temporarily ectopically implanted onto the forearm and foot, with microvascular anastomoses. When the stump condition allowed, and the soft-tissue defects were repaired, the ectopic implanted thumbs were replanted to their anatomic positions. RESULTS: Both thumbs survived the temporary ectopic implantation and second-stage replantation. The length of the thumbs was maintained, and the thumbs regained their function in 16- and 10-week follow-ups. CONCLUSIONS: Temporary ectopic implantation of amputated parts provides an innovative procedure for the salvage of amputated thumbs under special circumstances. Although this procedure is very demanding, it does deserve special consideration in reconstructive microsurgery, since it offers the possibility to salvage amputated thumbs with extensive soft tissue loss of the hand, by preserving the anatomy and restoring the function of severely injured hands.
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Traumatismos de la Mano/cirugía , Reimplantación/métodos , Pulgar/lesiones , Pulgar/cirugía , Adulto , Amputación Traumática , Niño , Desbridamiento , Antebrazo/cirugía , Humanos , MasculinoRESUMEN
OBJECTIVE: To investigate the clinical characteristics, treatment options and causes of misdiagnosis of ipsilateral femoral neck and shaft fractures. METHODS: Among 20 patients with ipsilateral femoral neck and shaft fractures, 19 were treated operatively and 1 was treated conservatively. Sixteen cases of femoral shaft fractures were treated by open reduction and internal fixation with compressive plate, and 2 cases were treated with interlocking intramedullary nailing. Eighteen femoral neck fractures were treated with cannulated screws. Another patient was treated with proximal femoral nail to fix both the neck and shaft. Delayed diagnosis for femoral neck fractures occurred in 2 cases preoperatively. RESULTS: A total of 19 patients were followed up. The follow up period ranged from 5 to 48 months with an average of 15 months. All the fractures were healed. CONCLUSION: For case of femoral shaft fracture caused by high energy injury, an AP pelvic film should be routinely taken. Once the femoral neck fracture is recognized, operative reduction and fixation should be performed in time. Femoral neck and shaft fractures should be fixed separately.
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Fracturas del Fémur/cirugía , Fracturas del Cuello Femoral/cirugía , Adulto , Anciano , Femenino , Fracturas del Fémur/diagnóstico , Fracturas del Cuello Femoral/diagnóstico , Fijación Interna de Fracturas , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Herein we report a case of Kimura's disease with unusual manifestations. A 46-year- old Chinese man presented with mass in scrotum which gradually increased in size for approximately 7 years. A computerized tomographic scan of abdomen revealed a soft-tissue density shadow in scrotum and enlargement of lymph nodes in groin and retroperitoneum. The scrotal mass was excised and the biopsy specimen revealed angiolymphoid hyperplasia with infiltration of eosinophils. In conclusion, clinical doctors should pay attention that the patient with eosinophilia and scrotal mass could be indicative for Kimura's disease.
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Hiperplasia Angiolinfoide con Eosinofilia/diagnóstico por imagen , Neoplasias de los Genitales Masculinos/diagnóstico por imagen , Hiperplasia Angiolinfoide con Eosinofilia/complicaciones , Hiperplasia Angiolinfoide con Eosinofilia/patología , Diagnóstico Diferencial , Eosinofilia/etiología , Humanos , Linfadenopatía/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Escroto , Tomografía Computarizada por Rayos XRESUMEN
Objective: To explore the change of hearing threshold of workers exposed to noise, establish an individual-based hearing loss early warning model, accurately and differentiated the health of workers exposed to noise. Methods: In September 2019, all physical examination data of 561 workers exposed to noise from an enterprise were collected since their employment. Three indicators of average hearing threshold of the better ear, namely, at high frequency, 4000 Hz and speech frequency, were constructed. The generalized estimating equation (GEE) was used to adjust gender and age and establish the warning model of each indicator. Finally, sensitive indicators and warning models were screened according to AUC and Yoden index. Results: Among the 561 workers exposed to noise, 26 (4.6%) workers had hearing loss. The sensitivity indicators were the average hearing threshold at speech frequency ≥20 dB, high frequency ≥30 dB and 4000 Hz ≥25 dB. The AUC of each index was 0.602, 0.794 and 0.804, and the Youden indexes were 0.204, 0.588 and 0.608, respectively. In GEE of hearing loss warning models, high-frequency hearing threshold ≥20 dB and 4000 Hz hearing threshold ≥25 dB were the optimal models, with AUC of 0.862. Conclusion: Combined with the changes of individual hearing threshold over the years, can accurately assess the risk of individual hearing loss of workers exposed to noise.
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Humanos , Pérdida Auditiva Provocada por Ruido/diagnóstico , Ruido en el Ambiente de Trabajo/efectos adversos , Audiometría , Sordera , Empleo , Exposición Profesional/efectos adversos , Enfermedades Profesionales/diagnósticoRESUMEN
OBJECTIVE: To investigate the biomechanical effect of major extremity vessels to choose appropriate repair methods for vascular injuries of the extremities. METHODS: The data of 385 patients (337 males and 48 females, aged 18-71 years, mean=32.6 years) including 403 injured vessels, who suffered from vascular injuries of the extremities and were treated in our hospital from October 1960 to August 2005, were studied retrospectively in this article. We compared the results of different repair methods for the defect of vessels and evaluated different injured vessels for repairing arterial injuries with anastomosis and venous graft, respectively. RESULTS: A significant difference was found between the defect lengths of the arteries repaired with anastomosis and venous graft (P less than 0.0001). The upper limits of the confidence interval in the defect lengths of the brachial artery, the femoral artery and the popliteal artery were 3.43 cm, 2.38 cm and 2.42 cm, respectively, when repaired with anastomosis. The lower limits were 2.16 cm, 2.16 cm and 1.63 cm, respectively, when repaired with venous graft. The defect length of each artery repaired with venous graft had linear correlation with the graft length. CONCLUSION: Because of the longitudinal biomechanical difference of human peripheral vessels, different options of repair are necessary for different arterial injuries.
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Vasos Sanguíneos/lesiones , Extremidades/irrigación sanguínea , Adolescente , Adulto , Anciano , Anastomosis Quirúrgica , Arterias/lesiones , Fenómenos Biomecánicos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Venas/trasplanteRESUMEN
OBJECTIVE: To evaluate the treatment for patients with major vascular injuries associated with traumatic orthopedic injuries. METHODS: A total of 196 patients, aged from 4-67 years with the mean age of 29.88 years, had major vascular injuries associated with traumatic orthopedic injuries and were treated in our hospital in a period of 44 years. The most common mechanism of trauma was blunt trauma (67.3%), open injuries accounted for 32.4% and 54.5% of the injuries were located in the lower extremities. The vascular injury frequently happened in the femoral artery (26.7%) and popliteal artery (20.3%). The treatment principle consisted of aggressive resuscitation, Doppler imaging and stable bone internal fixation with subsequent vascular repair and debridement. The vascular repair for injuries included end-to-end anastomosis (80 cases, 39.6%), interpositional vein graft (94, 46.5%), vascular decompression through fracture distraction (18, 8.9%), arterial ligation (6, 3.0%), vein patch (2, 1.0%), bypass graft (2, 1.0%), venous repair including autogenous vein graft (9, 24.3%) and ligation (28, 75.7%) and prophylactical fasciotomy (15, 7.4%). Postoperative amputation was performed in 16 cases (16.3%). RESULTS: No intraoperative death was observed and all fractures united within 6 months. Limbs were salvaged in 180 patients (91.8%). Among these patients, early complications were found in 19 patients (9.7%) and late complications were observed in 8 patients (4.1%). CONCLUSIONS: A well-organized approach, based on a specific treatment principle, not only improves clinical outcome but also does good to excellent functional recovery for patients with severe orthopedic injuries and concomitant vascular lesion.
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Vasos Sanguíneos/lesiones , Fracturas Óseas/complicaciones , Adolescente , Adulto , Niño , Preescolar , Femenino , Fijación Interna de Fracturas , Fracturas Abiertas/complicaciones , Humanos , Masculino , Persona de Mediana Edad , Estudios ProspectivosRESUMEN
OBJECTIVE: To introduce a posteromedial approach through the medial border of the medial head of gastrocnemius for reduction and reattachment of bony avulsion of the posterior cruciate ligament (PCL) from the tibia. METHODS: Eleven patients with avulsed tibial attachment of the PCL underwent an operative reduction and internal fixation through the posteromedial approach of the gastrocnemius in our department from February 1998 to March 2000. The skin incision was reversed L-shaped along the medial border of the medial head of the gastrocnemius and the posterior capsule was exposed by dissecting the medial border and lateral retraction, avoiding the damage of the popliteal neurovascular structures. After that, the posterior capsule was vertically dissected a little medially to the posterior intercondylar sulcus and just on the posterior medial tibial eminence positioned by finger palpation. Then the PCL and its tibial attachment were easily accessible. In the delayed cases, PCL peripheral releasing was necessary to overcome the ligament retraction and to refresh the fracture bed for optimal reduction and bony healing. At last, one or two biodegradable screws were used to fix the avulsed bone segment and 30 flexion knee plaster cast immobilization was regularly applied after the wound was closed. The evaluation included X-ray, posterior sag sign and posterior drawer test compared with the contralateral side. The functional assessment of the low limbs was not available because of concomitant injuries. RESULTS: The posteromedial approach of the gastrocnemius used in repair of tibial attachment avulsed injury of the PCL could provide benefit of clear anatomical exposure, few blood loss (20 ml on average), no need for detachment or reattachment of any structure. The patients were followed up for 11 months on an average (ranging from 6 months to 2 years). It demonstrated that bony healing was achieved within 4-6 weeks in cases of fresh injury and 7-9 weeks in cases of delayed injury. Six out of 8 fresh cases showed totally negative posterior sag sign or posterior drawer test but 2 had extra laxity for 1-2 mm. In 3 delayed cases, extra laxity for 3-4 mm was presented compared with the contralateral knee. CONCLUSIONS: The posteromedial approach of the gastrocnemius is ideal for internal fixation of avulsed tibial attachment of the PCL. It is fairly easy, safe, time-saving, applicable alternatives, in addition, the morbidity is rare and can also be used in management of posteromedial fracture of the medial femoral condyle and tibial plateau.
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Fijación Interna de Fracturas/métodos , Músculo Esquelético/cirugía , Ligamento Cruzado Posterior/cirugía , Fracturas de la Tibia/cirugía , Adolescente , Adulto , Humanos , Masculino , Persona de Mediana Edad , Selección de Paciente , Ligamento Cruzado Posterior/lesiones , Resultado del TratamientoRESUMEN
Repairing initial slight damage site into stable structures by engineering techniques is the leading strategy to mitigate the damage growth on large-size components used in laser-driven fusion facilities. For KH2PO4 crystals, serving as frequency converter and optoelectronic switch-Pockels cell, micro-milling has been proven the most promising method to fabricate these stable structures. However, tool marks inside repairing pit would be unavoidably introduced due to the wearing of milling cutter in actual repairing process. Here we quantitatively investigate the effect of tool marks on repairing quality of damaged crystal components by simulating its induced light intensification and testing the laser-induced damage threshold. We found that due to the formation of focusing hot spots and interference ripples, the light intensity is strongly enhanced with the presence of tool marks, especially for those on rear surfaces. Besides, the negative effect of tool marks is mark density dependent and multiple tool marks would aggravate the light intensification. Laser damage tests verified the role of tool marks as weak points, reducing the repairing quality. This work offers new criterion to comprehensively evaluate the quality of repaired optical surfaces to alleviate the bottleneck issue of low laser damage threshold for optical components in laser-driven fusion facilities.
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OBJECTIVE: To compare the efficacy on vertebrobasilar insufficiency (VBI) between auricular acupuncture therapy and oral administration of medicine. METHODS: Sixty patients of VBI were randomized into an auricular acupuncture therapy group and a medicine group, 30 cases in each one. In the auricular acupuncture group, acupuncture was applied bilaterally to gan (CO12) and jiejie (HX8) on the ears and needles were retained for 15 min. After needle withdrawal, the vaccariae semen were fixed with plaster at naogan (AT3, 4i), zhen (AT3), jing (AH12), shen (CO10) and pi (CO13) on the ears. In the medicine group, flunarizine hydrochloride capsules (Sibelium), 5mg were prescribed for oral administration, once every night. The treatment lasted continuously for 2 weeks (14 days) in the two groups. In 2 weeks, the clinical efficacy was assessed and the transcranial doppler (TCD) examination was performed. RESULTS: After treatment, the symptom scores were all apparently reduced in the patients of the two groups (P < 0.01, P < 0.05). Compared with the medicine group, the reduced score was much more obvious in the auricular acupuncture group (P < 0.05), indicating the significant difference. After treatment, with TCD examination, the blood velocity was increased to different degrees in the patients of low velocity type in the auricular acupuncture group and the medicine group; that was reduced to different degrees in the patients of high velocity type in the auricular acupuncture group and the medicine group. All of them were different significantly as compared with those before treatment (all P < 0.05). But the difference was not significant between the two groups (both P > 0.05). In comparison of clinical efficacy between the two groups, the effective rate was 93.3% (28/30) in the acupuncture group and better than 76.7% (23/30) in the medicine group, indicating the significant difference in comparison (P < 0.05). CONCLUSION: The auricular acupuncture therapy achieves the definite efficacy on VBI and the efficacy is better than flunarizine hydrochloride capsules.
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Acupuntura Auricular , Insuficiencia Vertebrobasilar/terapia , Puntos de Acupuntura , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Resultado del TratamientoRESUMEN
It is of vital significance to conduct active postmarketing surveillance of Chinese medicine, as an active response to laws, rules and guidelines issued by the China Food and Drug Administration. These will provide technological support in evaluating adverse drug reactions (ADRs) or adverse drug events (ADEs). The expert consensus for postmarketing surveillance focuses on two surveillance designs; one is a large sample registry study to explore general population ADR/ADE characteristics, the other is a nested case-control study to explore the characteristic and mechanisms of ADRs.
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OBJECTIVE: To investigate the morphological changes of deep fascia subjected to distraction in a rabbit model of leg lengthening. METHODS: The animal model of leg lengthening was established in 20 New Zealand white rabbits using a unilateral external fixator with 4 half pins medially fixed to the tibia, and osteotomy was performed between the second and the third pins. The distraction was initiated 7 days after the osteotomy procedure, with the rate of 1 and 2 mm/d in 2 steps, and proceeded until 10% and 20% increases in the initial length of the tibia had been achieved. The deep fascia samples were studied by the hematoxylin-eosin stain, the Masson-trichome staining, and the JEM2000EX electron microscopy. RESULTS: Under light, the cross section of normal deep fascia without distraction consisted of 3 layers. Whereas in the longitudinal sections, the deep fascia consisted of wavy collagen fibers. The normal deep fascia consisted of fibrocyte and collagenous fibrils under electron microscopy. After leg lengthening, the morphology of the fascia distracted at each rate changed. Under light, the fascia distracted at each rate kept the normal 3 layers in the cross sections. The fascia subjected to distraction at a rate of 2 mm/d showed injuries of collagen fibers. Under electron microscopy, the fascia distracted at a rate of 2 mm/d showed active metabolism to repair the necrotic collagenous fibrils. Whereas the fascia subjected to distraction at a rate of 1 mm/d showed regenerative changes. The endotheliocyte of capillaries within the deep fascia subjected to distraction at a rate of 1mm/d with 20% lengthening of tibia was metabolically active. CONCLUSIONS: The tension stress, which is applied in leg lengthening and deformity correction as described by Ilizarov, has a great effect upon the fascia, which is always related to the function of the involved limb. The appropriate regimen of distraction at the rate of 1 mm/d with 20% lengthening of tibia leads to the regenerative changes in deep fascia, ultimately close to the morphological structure of normal under the condition of this investigation.