Health-related quality of life in individuals with metabolic syndrome: A cross-sectional study.

INTRODUCTION AND OBJECTIVES: Metabolic syndrome (MetS) is a combination of various cardiovascular risk factors with a major impact on morbidity and premature mortality. However, the impact of MetS on self-reported health-related quality of life (HRQoL) is unknown. This study evaluated the HRQoL in a Spanish adult population aged 55 years and older with MetS. METHOD: A cross-sectional analysis was performed with baseline data from the PREDIMED-Plus multicentre randomized trial. The participants were 6430 men and women aged 55-75 years with overweight/obesity (body mass index ≥27 and ≤40kg/m2) and MetS. The SF-36 questionnaire was used as a tool to measure HRQoL. Scores were calculated on each scale of the SF-36 by gender and age. RESULTS: Participants showed higher scores in the social function (mean 85.9, 95% CI; 85.4-86.4) and emotional role scales (mean 86.8, 95% CI; 86.0-87.5). By contrast, the worst scores were obtained in the aggregated physical dimensions. In addition, men obtained higher scores than women on all scales. Among men, the worst score was obtained in general health (mean 65.6, 95% CI; 65.0-66.2), and among women, in body pain (mean 54.3, 95%CI; 53.4-55.2). A significant decrease was found in the aggregated physical dimensions score among participants 70-75 years old, but an increased one in the aggregated mental dimensions, compared to younger participants. CONCLUSIONS: Our results reflect that the MetS may negatively affect HRQoL in the aggregated physical dimensions, body pain in women, and general health in men. However, this adverse association was absent for the psychological dimensions of HRQoL, which were less affected.

Health-related quality of life in individuals with metabolic syndrome: a cross-sectional study / Calidad de vida relacionada con la salud en individuos con síndrome metabólico: un estudio descriptivo

INTRODUCTION AND OBJECTIVES: Metabolic syndrome (MetS) is a combination of various cardiovascular risk factors with a major impact on morbidity and premature mortality. However, the impact of MetS on self-reported health-related quality of life (HRQoL) is unknown. This study evaluated the HRQoL in a Spanish adult population aged 55 years and older with MetS. METHOD: A cross-sectional analysis was performed with baseline data from the PREDIMED-Plus multicentre randomized trial. The participants were 6430 men and women aged 55-75 years with overweight/obesity (body mass index ≥27 and ≤40kg/m2) and MetS. The SF-36 questionnaire was used as a tool to measure HRQoL. Scores were calculated on each scale of the SF-36 by gender and age. RESULTS: Participants showed higher scores in the social function (mean 85.9, 95% CI; 85.4-86.4) and emotional role scales (mean 86.8, 95% CI; 86.0-87.5). By contrast, the worst scores were obtained in the aggregated physical dimensions. In addition, men obtained higher scores than women on all scales. Among men, the worst score was obtained in general health (mean 65.6, 95% CI; 65.0-66.2), and among women, in body pain (mean 54.3, 95%CI; 53.4-55.2). A significant decrease was found in the aggregated physical dimensions score among participants 70-75 years old, but an increased one in the aggregated mental dimensions, compared to younger participants. CONCLUSIONS: Our results reflect that the MetS may negatively affect HRQoL in the aggregated physical dimensions, body pain in women, and general health in men. However, this adverse association was absent for the psychological dimensions of HRQoL, which were less affected

INTRODUCCIÓN Y OBJETIVOS: El síndrome metabólico (SM) es la combinación de diversos factores de riesgo cardiovascular que pueden derivar en un mayor impacto en la morbimortalidad prematura. Sin embargo, el impacto del SM en la calidad de vida relacionada con la salud (CVRS) es desconocido. El objetivo de este estudio es evaluar la CVRS en la población adulta española de 55 años o más con SM. MÉTODOS: Se realizó un análisis transversal con los datos del ensayo PREDIMED-Plus. Seis mil cuatrocientos treinta varones y mujeres entre 55-75 años con sobrepeso/obesidad y SM. El instrumento de medida de la CVRS fue el cuestionario SF-36. Cada escala del SF-36 fue descrita y estratificada por sexo. RESULTADOS: Los participantes mostraron valores más altos en las escalas función social (media: 85,9; IC 95%: 85,4-86,4) y rol emocional (media: 86,8; IC 95%: 86,0-87,5). En los varones, la peor puntuación fue en la dimensión salud general (media: 65,6; IC 95%: 65,0-66,2) y en las mujeres el dolor corporal (media: 54,3; IC 95%: 53,4-55,2). Además, los varones obtuvieron puntuaciones más altas en todas las escalas. En la escala función física en varones se encontró una disminución significativa de la CVRS en los participantes entre 70 y 75 años en comparación con los más jóvenes. Las peores puntuaciones se obtuvieron en las dimensiones físicas agregadas. CONCLUSIONES: El SM afecta de manera negativa a la CVRS en las dimensiones agregadas físicas, haciendo especial hincapié en la esfera dolor corporal en mujeres y salud general en varones. Sin embargo, las esferas psicológicas se encuentran menos afectadas por el SM

La presión arterial domiciliaria se asocia con la hipertrofia concéntrica del ventrículo izquierdo / Home blood pressure is associated with concentric hypertrophy of the letf ventricle

Introducción. La hipertrofia del ventrículo se relaciona con el grado de hipertensión arterial e incrementa el riesgo de sufrir eventos cardiovasculares. Hay controversia acerca de la asociación entre las cifras de presión arterial medida por los distintos métodos clínicos y domiciliarios y la morfología ecográfica del ventrículo izquierdo. El objetivo ha sido investigar posibles asociaciones entre los parámetros ecocardiográficos de hipertrofia y las presiones clínicas y por automedida domiciliaria. Material y métodos. Se realizó determinación de presión arterial clínica y ambulatoria mediante automedida domiciliaria de presión arterial y ecocardiograma a 122 pacientes hipertensos (61,5% hombres). Se dividió a los pacientes según el patrón ecográfico del ventrículo izquierdo: normal, remodelado concéntrico, hipertrofia excéntrica y concéntrica. Resultados. Solamente 51 pacientes (41,8 %) mostraron un patrón ecográfico ventricular izquierdo normal. El 25,4 % tenía remodelado concéntrico y el 32,8 % hipertrofia ventricular izquierda. Existió asociación estadísticamente significativa entre la presión arterial sistólica clínica y el índice de masa de ventrículo izquierdo ajustando por edad, sexo e índice de masa corporal (ß = 0,004; intervalo de confianza del 95% [IC 95 %]: 0,001 a 0,007 [p = 0,022]), y entre la presión de pulso de automedida y el grosor relativo de pared (ß = 0,006; IC 95 %: 0,001 a 0,010 [p = 0,013]). La presión de pulso domiciliaria fue estadísticamente superior en los pacientes con grosor relativo de la pared mayor de 0,44. Discusión. Se han encontrado evidencias que sugieren la asociación de las mediciones de presión arterial de automedida con los patrones de remodelado e hipertrofia concéntrica que predicen mayor riesgo cardiovascular, las cuales no se relacionan con las mediciones clínicas. Estos resultados apoyan la utilización de automedida domiciliaria en la evaluación de los pacientes hipertensos

Introduction. Ventricle hypertrophy is related with the degree of arterial hypertension and increases risk of suffering cardiovascular events. There is a debate on the association between the blood pressure values measured by different clinical and home methods and ultrasonographic morphology of the left ventricle. The objective has been to investigate possible associations between echocardiographic parameters of hypertrophy and clinical pressures and by home self-measurement. Material and methods. Clinical and out-patient blood pressure was measured by home blood pressure monitoring and echocardiogram in 122 hypertensive patients (61.5 % men). Patients were divided according to the ultrasonographic pattern of the left ventricle: normal, concentric remodeling, eccentric and concentric hypertrophy. Results. Only 51 patients (41.8 %) had a normal left ventricular ultrasonographic pattern. A total of 25.4 % had concentric remodeling and 32.8 % left ventricular hypertrophy. There was a statistically significant association between the clinical systolic blood pressure and the left ventricle mass index, adjusting by age, gender and body mass index [ß = 0.004; 95 % confidence interval (95 % CI): 0.001 to 0.007 (p = 0.022)], and between self-measured pulse pressure and relative wall thickness [ß = 0.006; 95 % CI: 0.001 to 0.010; (p = 0.013)]. Home pulse pressure was statistically greater in patients with relative wall thickness greater than 0.44. Discussion. Evidence has been found that suggests the association of the self-measurement blood pressure measurement with remodeling patterns and concentric hypertrophy, that predict greater cardiovascular risk, these not being related with clinical measurements. These results support the use of home self-measurement in the evaluation of hypertensive patients