1.
Chem Commun (Camb)
; 53(100): 13316-13319, 2017 Dec 14.
Artículo
en Inglés
| MEDLINE
| ID: mdl-29192920
RESUMEN
Non-enzymatic glycation of extracellular matrix with (U-13C5)-d-ribose-5-phosphate (R5P), enables in situ 2D ssNMR identification of many deleterious protein modifications and crosslinks, including previously unreported oxalamido and hemiaminal (CH3-CH(OH)NHR) substructures. Changes in charged residue proportions and distribution may be as important as crosslinking in provoking and understanding harmful tissue changes.