RESUMEN
The review details the features and mechanisms of the formation of various types of pain. The emphasis is placed on the occurrence of pain syndrome in various ophthalmological diseases, particularly in dry eye syndrome. The article also presents literature data on the role of cytokines in the formation of a neuroinflammatory cascade affecting damage to corneal nerve fibers and the development of pain syndrome, which is a characteristic feature of a subtype of dry eye disease - burning eye syndrome.
Asunto(s)
Síndromes de Ojo Seco , Neuralgia , Humanos , Síndromes de Ojo Seco/diagnóstico , Síndromes de Ojo Seco/etiología , Córnea , Citocinas , Fibras NerviosasRESUMEN
Burning eye syndrome is a chronic neuropathic pain syndrome, which is characterized by dysesthesia, spontaneous pain, allodynia and hyperalgesia. The review describes clinical features and presents available data on possible methods of diagnosis and therapy of this condition.
Asunto(s)
Síndromes de Ojo Seco , Quemaduras Oculares , Neuralgia , Humanos , Neuralgia/diagnóstico , Neuralgia/etiología , Neuralgia/terapia , Síndromes de Ojo Seco/diagnóstico , Síndromes de Ojo Seco/etiología , Síndromes de Ojo Seco/terapiaRESUMEN
The data on examination of 83 patients in acute period of cerebral stroke caused by arterial hypertension and 30 healthy controls are presented. In all the patients, content of Fas expressed lymphocytes (CD95), indirectly suggesting apoptosis, has been determined. The level of Fas/Apo-1+ lymphocytes was significantly higher comparing to the control group. Cerebral stroke severity positively correlated with Fas/Apo-1+ lymphocytes. The higher was a level of monoclonal antibodies CD95, the poorer was the course and prognosis both for recovering and for life. This correlation argues for a role of Fas/Apo-1+ lymphocytes in the apoptotic process, and the level of their expression reflects that of apoptosis in damaged brain tissue and serves as a sign of immune inflammation in response to acute cerebral disaster.