Harnessing Paleohydrologic Modeling to Solve a Prehistoric Mystery.

A riddle arises at the Epipaleolithic and Neolithic sites that dot the lower Jordan Valley. The area has no water resources yet it has long been a focus of inquiry into the transition from mobile hunter-gatherer to sedentary agriculture-based cultures. How then is there such clear evidence of life here, and particularly at such a critical moment in human evolution? Keen to unravel this conundrum, a numerical hydrological model was devised to simulate the groundwater flow field within the Eastern Aquifer of the Judea and Samaria Mountains during the transition from the last glacial to the current interglacial. The model exhibits a range of groundwater flow regimes that prevailed in the past, demonstrating that there was once much larger groundwater discharge at these sites.

Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia.

Anatolia was home to some of the earliest farming communities. It has been long debated whether a migration of farming groups introduced agriculture to central Anatolia. Here, we report the first genome-wide data from a 15,000-year-old Anatolian hunter-gatherer and from seven Anatolian and Levantine early farmers. We find high genetic continuity (~80-90%) between the hunter-gatherers and early farmers of Anatolia and detect two distinct incoming ancestries: an early Iranian/Caucasus related one and a later one linked to the ancient Levant. Finally, we observe a genetic link between southern Europe and the Near East predating 15,000 years ago. Our results suggest a limited role of human migration in the emergence of agriculture in central Anatolia.

The earliest matches.

Cylindrical objects made usually of fired clay but sometimes of stone were found at the Yarmukian Pottery Neolithic sites of Sha'ar HaGolan and Munhata (first half of the 8(th) millennium BP) in the Jordan Valley. Similar objects have been reported from other Near Eastern Pottery Neolithic sites. Most scholars have interpreted them as cultic objects in the shape of phalli, while others have referred to them in more general terms as "clay pestles," "clay rods," and "cylindrical clay objects." Re-examination of these artifacts leads us to present a new interpretation of their function and to suggest a reconstruction of their technology and mode of use. We suggest that these objects were components of fire drills and consider them the earliest evidence of a complex technology of fire ignition, which incorporates the cylindrical objects in the role of matches.

Dynamic Refraction Stereo.

In this paper we consider the problem of reconstructing the 3D position and surface normal of points on an unknown, arbitrarily-shaped refractive surface. We show that two viewpoints are sufficient to solve this problem in the general case, even if the refractive index is unknown. The key requirements are 1) knowledge of a function that maps each point on the two image planes to a known 3D point that refracts to it, and 2) light is refracted only once. We apply this result to the problem of reconstructing the time-varying surface of a liquid from patterns placed below it. To do this, we introduce a novel "stereo matching" criterion called refractive disparity, appropriate for refractive scenes, and develop an optimization-based algorithm for individually reconstructing the position and normal of each point projecting to a pixel in the input views. Results on reconstructing a variety of complex, deforming liquid surfaces suggest that our technique can yield detailed reconstructions that capture the dynamic behavior of free-flowing liquids.

Prospective audit of a one-centre combined nuchal translucency and triple test programme for the detection of trisomy 21.

OBJECTIVES: To determine detection and false-positive rates for trisomy 21 using two-stage combined nuchal translucency (NT) and triple testing, whilst disclosing abnormal nuchal measurements at the scan. METHODS: A prospective audit in a UK women's hospital, of 3188 women with singleton pregnancies, requesting screening for trisomy 21. Median age was 37 years (range 19-46). Women were offered NT screening at 11 to 14 weeks. Those with NT > or =3 mm were offered chorionic villus sampling. Those declining CVS, and those with NT <3 mm, were offered early triple tests. Women with a term combined risk of trisomy 21 > or = 1:250, based on age, NT, and triple test results were offered amniocentesis. RESULTS: Using a 3-mm NT 'cut-off' identified 16/25 cases of trisomy 21 (64%; 95% CI 38.8, 78.9). Of 2725 women who had a combined nuchal plus triple test assessment, 79 (2.6%) had a > or = 1:250 term risk of trisomy 21. Forty (1.3%) had amniocentesis identifying 6/9 remaining cases (67%:95% CI:27.9, 92.5). Overall, the detection rate was 88% (95% CI:68.8, 97.5) for a 4.8% FPR. For the screened population, to achieve an 88% detection rate using the triple test alone, the predicted FPR would be 20%. Conversely, for an FPR of 4.8% using the triple test alone, the detection rate would be only 60%. CONCLUSION: In a high-risk group, the combination of NT with triple test offers detection of trisomy 21 at least equivalent to either test, while allowing disclosure of an abnormal NT at the scan and reducing the FPR. Importantly, the FPR is less than 5%, considerably lower than expected for triple test alone for this population.