Prevalence of hepatitis C in patients with non-affective psychotic disorders.

INTRODUCTION: the goal of this study was to determine the prevalence of hepatitis C virus (HCV) infection in patients with non-affective psychotic disorders and to compare it with population-based data. MATERIAL AND METHODS: an observational study was performed that measured anti-HCV antibodies (HCV-RNA in case of seropositivity) in 425 serum samples from patients with non-affective psychosis. Eight patients were positive for anti-HCV (1.9 %) and five had detectable HCV-RNA (1.2 %). The prevalence of viremia was significantly higher than in the general population (OR: 5.4; 95 % CI: 1.9-14.6). CONCLUSIONS: patients with non-affective psychotic disorder have a higher prevalence of active infection than that of the general population and should undergo systematic screening.

Q fever, a rare cause of secondary hemophagocytic lymphohistiocytosis.

Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome in which Coxiella burnetii is a very infrequent etiology. We present the case of a 62-year-old male with progressive pulmonary infiltrates, fever, hepatitis, and bicytopenia despite broad spectrum antibiotics. A thorough clinical evaluation led to a high suspicion of Coxiella burnetii infection, subsequently confirmed through a positive serum polymerase chain reaction (PCR) analysis. HLH diagnosis was established based on the fulfillment of 5/8 diagnostic criteria, obviating the need for a bone marrow biopsy. Targeted antibiotic treatment and dexamethasone led to full recovery within two weeks, eliminating the need for stronger immunosuppressive therapy.

Prevalencia de hepatitis C en pacientes con trastornos psicóticos no afectivos / No disponible

INTRODUCCIÓN: nuestro objetivo fue determinar la prevalencia de infección por virus de la hepatitis C (VHC) en pacientes con trastornos psicóticos no afectivos y compararla con los datos poblacionales. MATERIAL Y MÉTODOS: se realizó un estudio observacional mediante la determinación de anti-VHC (RNA-VHC en los seropositivos) sobre 425 muestras séricas de pacientes con psicosis no afectiva. RESULTADOS: ocho pacientes presentaron anti-VHC positivo (1,9 %) y cinco, RNA-VHC detectable (1,2 %). La prevalencia de viremia fue significativamente mayor que la de la población general (OR 5,4; IC 95 %: 1,9-14,6). CONCLUSIONES: los pacientes con trastorno psicótico no afectivo presentan una prevalencia de infección activa superior a la población general y deberían ser objeto de un cribado sistemático

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