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1.
HIS-388, a novel orally active and long-acting 11ß-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models.
J Pharmacol Exp Ther
; 351(1): 181-9, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-25100752
2.
Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg Med Chem Lett
; 23(6): 1617-21, 2013 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23414800
3.
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett
; 22(23): 7036-40, 2012 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23072865
4.
Discovery and structure-activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2.
Bioorg Med Chem Lett
; 22(13): 4358-61, 2012 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22633690
5.
Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists.
Bioorg Med Chem Lett
; 22(22): 6876-81, 2012 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23046963
6.
Discovery and structure-activity relationships of urea derivatives as potent and novel CCR3 antagonists.
Bioorg Med Chem Lett
; 22(15): 4951-4, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22749826
7.
Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists.
Bioorg Med Chem
; 17(16): 5989-6002, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19620010
8.
(3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Bioorg Med Chem Lett
; 18(20): 5435-8, 2008 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18819797
9.
Design and synthesis of 6-fluoro-2-naphthyl derivatives as novel CCR3 antagonists with reduced CYP2D6 inhibition.
Bioorg Med Chem
; 16(18): 8607-18, 2008 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18752960
10.
Synthesis and structure-activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists.
Bioorg Med Chem
; 16(1): 144-56, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17951061
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