Attenuation assessment of medical protective eyewear: the AVEN experience.

The goal of this paper is to test the attenuation capability of seven models of protective eyewear used in routine clinical practice. Scattered radiation from a standard patient was simulated by using a water tank located over the treatment couch of a GE Innova 3100 x-ray angiography system. Seven protective eyewear models were tested using an anthropomorphic phantom mimicking the first operator. At each test, 4 thermoluminiscent dosimeters were placed on the phantom (respectively in front of the protective eyewear, under the eyewear, on the left earpiece and at chest level) in order to have an eyewear-independent reference. A test session without glasses was also acquired. Each model was tested with standard posterior-anterior (PA) projections and the two most common protective eyewear were tested using LAO90° and LAO45°CRA30° projections. A worst-case scenario was created to be sure of having an upper limit for the assessment of eyewear attenuation in routine clinical practice. In PA projections, the absolute attenuation value ranged between 71% and 81%, while relative attenuation between dose measured at eye lens and that measured at eyewear earpiece ranged from 67% to 85%. The slightly wider range was probably due to scatter radiation variability; anyway, differences are still included in the variable uncertainty of experimental measurements. It is worth noting that #3 eyewear model (the one without lateral protection) allows an attenuation similar to that of #5 eyewear model (with 0.5 mm lead lateral protection) in LAO90° and LAO45°CRA30° projections. Despite the experimental limitations, a description of the radiation properties of protective eyewear concerning radiation attenuation can be useful to rely on protection devices which can be used in routine clinical practice.

Reducing absorbed dose to eye lenses in head CT examinations: the effect of bismuth shielding.

The eye lens is considered to be among the most radiosensitive human tissues. Brain CT scans may unnecessarily expose it to radiation even if the area of clinical interest is far from the eyes. The aim of this study is to implement a bismuth eye lens shielding system for Head-CT acquisitions in these cases. The study is focused on the assessment of the dosimetric characteristics of the shielding system as well as on its effect on image quality. The shielding system was tested in two set-ups which differ for distance ("contact" and "4 cm" Set up respectively). Scans were performed on a CTDI phantom and an anthropomorphic phantom. A reference set up without shielding system was acquired to establish a baseline. Image quality was assessed by signal (not HU converted), noise and contrast-to-noise ratio (CNR) evaluation. The overall dose reduction was evaluated by measuring the CTDIvol while the eye lens dose reduction was assessed by placing thermoluminescent dosimeters (TLDs) on an anthropomorphic phantom. The image quality analysis exhibits the presence of an artefact that mildly increases the CT number up to 3 cm below the shielding system. Below the artefact, the difference of the Signal and the CNR are negligible between the three different set-ups. Regarding the CTDI, the analysis demonstrates a decrease by almost 12 % (in the "contact" set-up) and 9 % (in the "4 cm" set-up). TLD measurements exhibit an eye lens dose reduction by 28.5 ± 5 and 21.1 ± 5 % respectively at the "contact" and the "4 cm" distance. No relevant artefact was found and image quality was not affected by the shielding system. Significant dose reductions were measured. These features make the shielding set-up useful for clinical implementation in both studied positions.

A comparison between in vivo and ex vivo HR-MAS 1H MR spectra of a pediatric posterior fossa lesion.

The present case report was aimed at identifying the molecular profile characteristic of a primitive neuro-ectodermal tumor (PNET) in a 3-year-old child affected by a lesion localized in the cerebellar region. The histological diagnosis was medulloblastoma. In vivo single voxel 1H magnetic resonance spectroscopy (MRS) shows high specificity in detecting the main metabolic alterations in the primitive cerebellar lesion; a very high amount of the choline-containing compounds and very low level of creatine derivatives and N-acetylaspartate. Ex vivo high resolution magic angle spinning (HR-MAS) 1H magnetic resonance spectroscopy, performed at 9.4 Tesla on the neoplastic specimen collected during surgery, allows for the unambiguous identification of several metabolites giving a more in-depth evaluation of the metabolic pattern of the lesion. The ex vivo HR-MAS MR spectra show that the spectral detail is much higher than that obtained in vivo and that, for example, myo-inositol, taurine and phosphorylethanolamine contribute to the in vivo signal at 3.2 ppm, usually attributed to choline-containing compounds. In addition, the spectroscopic data appear to correlate with some morphological features of the medulloblastoma. Consequently, the present study shows that ex vivo HR-MAS 1H MRS is able to strongly improve the clinical possibility of in vivo MRS and can be used in conjunction with in vivo spectroscopy for clinical purposes.

In vivo 3 T MR diffusion tensor imaging for detection of the fibre architecture of the human uterus: a feasibility and quantitative study.

OBJECTIVE: The aim of this study was to investigate the feasibility of depicting fibre architecture of human uteri in vivo using 3 T MR diffusion tensor imaging (MR-DTI) with a three-dimensional (3D) tractography approach. Quantitative results were provided. METHODS: In vivo 3 T MR-DTI was performed on 30 volunteers (9 Caesarean delivery). Main diffusion directions reflecting the fibre orientation were determined using sensitivity-encoding single-shot echo planar imaging with diffusion-sensitised gradients (b=600 mm(2) s(-1)) along 32 directions. A deterministic fibre-tracking algorithm was used to show in vivo fibre architecture, compared with ex vivo histological slides of cadaveric uteri. The number of fibres, the fibre density, the fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) were measured in 13 volunteers. RESULTS: Anisotropy was found in most regions of normal uteri and the preferential order of uterine fibres depicted, consisting of two representative fibre directions: circular and longitudinal, as in ex vivo studies. Two-thirds of uteri with a Caesarean scar did not have the same orientation of fibres in the anterior isthmus when compared with non-scarred myometrium. Quantitative data were obtained from 13 volunteers: Caesarean-scarred uteri (n=5) showed lower fibre number and density in the scarred anterior isthmus than the nulliparous uteri (n=8). No significant differences were found in FA (0.42 ± 0.02, 0.41 ± 0.02; p=0.25) and ADC (1.82 ± 0.18 × 10(-3) mm(2) s(-1), 1.93 ± 0.25 × 10(-3) mm(2) s(-1); p=0.20). CONCLUSION: Fibre architecture of the human uterus can be depicted in vivo using 3 T MR-DTI. Advances in knowledge 3 T MR-DTI can help to provide an in vivo insight of uterine anatomy non-invasively, especially in females with previous Caesarean surgery, in order to provide better management of subsequent deliveries.

Phase Contrast MR as Non-Invasive Tool in the Diagnosis of Benign Intracranial Hypertension.

Idiopathic intracranial hypertension (IIH) is characterized by an increased intracranial pressure in the absence of expansive lesions or cerebrospinal fluid (CSF) circulation obstructions. Its physiopathology is still not fully understood. The diagnosis is currently established on clinical grounds (Dandy criteria) along with an invasive measurement of CSF dynamic parameters through the infusion test. This study compares the invasive pressure measurements with the biomechanical CSF parameters derived from a phase-contrast MR protocol to evaluate the accuracy and reliability of the phase-contrast MR protocol.