RESUMEN
The COVID-19 pandemic has brought significant changes in managing of patients with rheumatoid arthritis. Rituximab-treated patients were more susceptible to severe infection. This required a "switch" to another genetically engineered drug in the patients with high risk of adverse COVID-19. In this study, we assessed the severity of immune response to SARS-CoV-2 antigens in rituximab-treated patients with rheumatoid arthritis vaccinated with the combined vector vaccine Gam-COVID-Vac. Insufficient formation of the humoral response and a high level of T-cell response to SARS-CoV-2 antigens in this group of patients were revealed. An imbalance of cellular and humoral response may play a role in more severe COVID-19 in rituximab-treated patients with rheumatoid arthritis.
Asunto(s)
Artritis Reumatoide , Vacunas contra la COVID-19 , COVID-19 , Inmunidad Humoral , Rituximab , SARS-CoV-2 , Artritis Reumatoide/inmunología , Artritis Reumatoide/tratamiento farmacológico , Humanos , Rituximab/uso terapéutico , Inmunidad Humoral/efectos de los fármacos , SARS-CoV-2/inmunología , COVID-19/inmunología , COVID-19/prevención & control , Persona de Mediana Edad , Masculino , Femenino , Vacunas contra la COVID-19/inmunología , Linfocitos T/inmunología , Linfocitos T/efectos de los fármacos , Anciano , Anticuerpos Antivirales/inmunología , Anticuerpos Antivirales/sangre , Adulto , Antirreumáticos/uso terapéutico , VacunaciónRESUMEN
The data of genome-wide association analysis suggest that human 6p21.3 chromosomal region (localization of HLA genes) contains polymorphic loci influencing the risk of developing non-Hodgkin's lymphomas. We analyzed association of rs2647012 and rs805288 loci with the risk for non-Hodgkin's malignant lymphomas in the population of Western Siberia. Allele and genotype frequencies were determined in the group of 298 patients and in the control group including 551 individuals. Subgroups of diffuse large B-cell lymphoma (86 patients) and follicular lymphoma (25 patients) were analyzed separately. An association of rs2647012 Ð/Ð genotype with increased risk of the disease (OR = 2.78, p = 0.002) was detected in the subgroup of diffuse large B-cell lymphoma.
Asunto(s)
Estudio de Asociación del Genoma Completo/métodos , Linfoma no Hodgkin/genética , Adulto , Anciano , Alelos , Femenino , Genotipo , Humanos , Masculino , Persona de Mediana Edad , Polimorfismo Genético/genética , SiberiaRESUMEN
We analyzed the association of polymorphic variants of rs917997 (G/A) locus in IL18RAP gene and rs187238 (G/C) locus in IL18 gene with the risk of malignant non-Hodgkin's lymphomas in Novosibirsk population. Allele and genotype frequencies of the above loci were determined in patients (243 persons) and control group (371 persons) and compared using χ(2) test. None of the analyzed loci showed statistically significant association with the risk of malignant non-Hodgkin's lymphomas.