RESUMEN
PURPOSE/OBJECTIVES: To examine the daily maternal caregiving demands for adolescent and young adult survivors of pediatric brain tumors who live with their families. DESIGN: A secondary analysis was conducted on interview data gathered during a large mixed-methods study that focused on perceived maternal caregiver competency and survivor health-related quality of life. SETTING: Home interviews. SAMPLE: A purposive sample of 46 maternal caregivers was selected from participants in the larger study. METHODS: Semistructured interviews were conducted with mothers. A directed content analysis was informed by Sullivan-Bolyai's framework describing the components of primary caregiving. MAIN RESEARCH VARIABLES: Caregiving demands. FINDINGS: Data regarding four main categories of maternal daily caregiving demands were identified from 25 of the 46 interviews. CONCLUSIONS: Potential day-to-day management tasks or demands of mothers of adolescent and young adult survivors of pediatric brain tumors were identified. IMPLICATIONS FOR NURSING: The major demands of caregiving are similar to those for children with other chronic conditions, with the addition of assisting with everyday responsibilities and fostering psychosocial health.
Asunto(s)
Neoplasias Encefálicas/enfermería , Cuidadores/psicología , Enfermedad Crónica/enfermería , Atención Domiciliaria de Salud/psicología , Madres/psicología , Sobrevivientes , Adaptación Psicológica , Adolescente , Adulto , Anciano , Neoplasias Encefálicas/psicología , Niño , Preescolar , Enfermedad Crónica/psicología , Femenino , Humanos , Lactante , Masculino , Persona de Mediana Edad , Philadelphia , Calidad de Vida , Estrés Psicológico , Encuestas y Cuestionarios , Adulto JovenRESUMEN
Renal disease represents a major health problem that often results in end-stage renal failure necessitating dialysis and eventually transplantation. Historically these diseases have been studied with patient observation and screening, animal models, and two-dimensional cell culture. In this review, we focus on recent advances in tissue engineered kidney disease models that have the capacity to compensate for the limitations of traditional modalities. The cells and materials utilized to develop these models are discussed and tissue engineered models of polycystic kidney disease, drug-induced nephrotoxicity, and the glomerulus are examined in detail. The application of these models has the potential to direct future disease treatments and preclinical drug development.
Asunto(s)
Técnicas de Cultivo de Célula/métodos , Enfermedades Renales , Modelos Biológicos , Ingeniería de Tejidos/métodos , Animales , Técnicas de Cultivo de Célula/tendencias , Línea Celular Transformada , Evaluación Preclínica de Medicamentos/métodos , Evaluación Preclínica de Medicamentos/tendencias , Humanos , Enfermedades Renales/tratamiento farmacológico , Enfermedades Renales/patología , Fármacos Renales/uso terapéutico , Ingeniería de Tejidos/tendenciasRESUMEN
Heterogeneous nanoclusters with trimeric and core-shell architectures containing nanoparticles of different size and composition have been fabricated via site-specific PNA-"invasion" of DNA double helix. This novel strategy facilitates the incorporation of double-stranded DNA into the nanoparticle assembly design.