RESUMEN
Mebendazole, albendazole, levamisole and thiabendazole are well known as active drugs against several nematode species, and against cestodes as well, when the first two drugs are considered. None of the drugs have proven activity, however, against trematodes. We tested the effect of these drugs on the fecal shedding of schistosome eggs and the recovering of adult schistosomes, after portal perfusion in Schistosoma mansoni experimentally infected mice. Balb/c mice infected with 80 S. mansoni cercariae were divided into three groups, each in turn subdivided into four other groups, for each tested drug. The first group was treated with each one of the studied drugs 25 days after S. mansoni infection; the second group was submitted to treatment with each one of the drugs 60 days after infection. Finally, the third group, considered as control, received no treatment. No effect upon fecal shedding of S. mansoni eggs and recovering of schistosomes after portal perfusion was observed when mice were treated with either mebendazole or albendazole. Mice treated with either levamisole or thiabendazole, on the other hand, showed a significant reduction in the recovering of adult schistosomes after portal perfusion, mainly when both drugs were given during the schistosomula evolution period, i.e., 25 days after cercariae penetration, probably due to unspecific immunomodulation.
Asunto(s)
Antihelmínticos/farmacología , Bencimidazoles/farmacología , Modelos Animales de Enfermedad , Schistosoma mansoni/efectos de los fármacos , Esquistosomiasis/tratamiento farmacológico , Tiazoles/farmacología , Animales , Femenino , Masculino , Ratones , Ratones Endogámicos BALB CAsunto(s)
Complejo Relacionado con el SIDA/complicaciones , Síndrome de Inmunodeficiencia Adquirida/complicaciones , Candidiasis Cutánea/epidemiología , Dermatomicosis/epidemiología , Tiña Versicolor/epidemiología , Complejo Relacionado con el SIDA/diagnóstico , Síndrome de Inmunodeficiencia Adquirida/diagnóstico , Adolescente , Adulto , Factores de Edad , Femenino , Humanos , Masculino , Factores SexualesRESUMEN
A patient who had a plaque on his forehead as the first sign of chronic myelomonocytic leukemia (CMML) is described. Histologic studies, which formerly led to the misdiagnosis of non-Hodgkin's lymphoma, revealed CMML with an unusual phenotype. This represents a rare type of CMML for the following reasons: (1) specific cutaneous involvement is rarely the first sign of CMML; (2) the unique phenotype was detected by immunohistology on lesional skin, specifically, the leukemic infiltrate was CD4-positive and notably negative for CD15, the pan myeloid/monocytic marker.
Asunto(s)
Leucemia Mielomonocítica Crónica/patología , Infiltración Leucémica , Piel/patología , Anciano , Antígenos CD , Humanos , Inmunofenotipificación , Leucemia Mielomonocítica Crónica/inmunología , MasculinoRESUMEN
The experience of noninvasive positive pressure ventilation (NPPV) in the pediatric setting is limited. The aim of the present study is to retrospectively evaluate the effectiveness of NPPV in pediatric immunocompromised patient admitted in our PICU (Pediatric Intensive Care Unit) for acute respiratory failure. Retrospective cohort study of children admitted to the PICU of Hospital do Cancer between June 1997 and May 2005 requiring ventilatory support. A total of 239 admissions were included. The first mechanical ventilation (MV) technique used was NPPV in 120 (50.2%) patients [noninvasive ventilation (NIV) group] and conventional MV in 119 (49.8%) [invasive ventilation (IV) group]; 25.8% of the patients from the NIV group subsequently required intubation. Patients in the IV group were more likely to be in a severe clinical status. Characteristics associated with severe clinical status were median value for therapeutic intervention scoring system score (37.5 points IV vs. 29 points NIV, P2 organs failure (63.6% IV vs. 36.4% NIV, Por=40 points (P=0.018). Our results encourage the use of NPPV as a first-line treatment in children with malignancies who develops acute respiratory failure, except in those with severe hemodynamic status.