Recent collisional history of (65803) Didymos.

The Double Asteroid Redirection Test (DART, NASA) spacecraft revealed that the primary of the (65803) Didymos near-Earth asteroid (NEA) binary system is not exactly the expected spinning top shape observed for other km-size asteroids. Ground based radar observations predicted that such shape was compatible with the uncertainty along the direction of the asteroid spin axis. Indeed, Didymos shows crater and landslide features, and evidence for boulder motion at low equatorial latitudes. Altogether, the primary seems to have undergone sudden structural failure in its recent history, which may even result in the formation of the secondary. The high eccentricity of Didymos sets its aphelion distance inside the inner main belt, where it spends more than 1/3 of its orbital period and it may undergo many more collisions than in the NEA region. In this work, we investigate the collisional environment of this asteroid and estimate the probability of collision with multi-size potential impactors. We analyze the possibility that such impacts produced the surface features observed on Didymos by comparing collisional intervals with estimated times for surface destabilization by the Yarkovsky-O'Keefe-Radzievskii-Paddack (YORP) effect. We find that collisional effects dominate over potential local or global deformation due to YORP spin up.

Mechanical properties of rubble pile asteroids (Dimorphos, Itokawa, Ryugu, and Bennu) through surface boulder morphological analysis.

Planetary defense efforts rely on estimates of the mechanical properties of asteroids, which are difficult to constrain accurately from Earth. The mechanical properties of asteroid material are also important in the interpretation of the Double Asteroid Redirection Test (DART) impact. Here we perform a detailed morphological analysis of the surface boulders on Dimorphos using images, the primary data set available from the DART mission. We estimate the bulk angle of internal friction of the boulders to be 32.7 ± 2. 5° from our measurements of the roundness of the 34 best-resolved boulders ranging in size from 1.67-6.64 m. The elongated nature of the boulders around the DART impact site implies that they were likely formed through impact processing. Finally, we find striking similarities in the morphology of the boulders on Dimorphos with those on other rubble pile asteroids (Itokawa, Ryugu and Bennu). This leads to very similar internal friction angles across the four bodies and suggests that a common formation mechanism has shaped the boulders. Our results provide key inputs for understanding the DART impact and for improving our knowledge about the physical properties, the formation and the evolution of both near-Earth rubble-pile and binary asteroids.

Effect of lung volume preservation during spontaneous breathing trial on successful extubation in patients receiving mechanical ventilation: protocol for a multicenter clinical trial.

BACKGROUND: In standard weaning from mechanical ventilation, a successful spontaneous breathing test (SBT) consisting of 30 min 8 cmH2O pressure-support ventilation (PSV8) without positive end-expiratory pressure (PEEP) is followed by extubation with continuous suctioning; however, these practices might promote derecruitment. Evidence supports the feasibility and safety of extubation without suctioning. Ultrasound can assess lung aeration and respiratory muscles. We hypothesize that weaning aiming to preserve lung volume can yield higher rates of successful extubation. METHODS: This multicenter superiority trial will randomly assign eligible patients to receive either standard weaning [SBT: 30-min PSV8 without PEEP followed by extubation with continuous suctioning] or lung-volume-preservation weaning [SBT: 30-min PSV8 + 5 cmH2O PEEP followed by extubation with positive pressure without suctioning]. We will compare the rates of successful extubation and reintubation, ICU and hospital stays, and ultrasound measurements of the volume of aerated lung (modified lung ultrasound score), diaphragm and intercostal muscle thickness, and thickening fraction before and after successful or failed SBT. Patients will be followed for 90 days after randomization. DISCUSSION: We aim to recruit a large sample of representative patients (N = 1600). Our study cannot elucidate the specific effects of PEEP during SBT and of positive pressure during extubation; the results will show the joint effects derived from the synergy of these two factors. Although universal ultrasound monitoring of lungs, diaphragm, and intercostal muscles throughout weaning is unfeasible, if derecruitment is a major cause of weaning failure, ultrasound may help clinicians decide about extubation in high-risk and borderline patients. TRIAL REGISTRATION: The Research Ethics Committee (CEIm) of the Fundació Unió Catalana d'Hospitals approved the study (CEI 22/67 and 23/26). Registered at ClinicalTrials.gov in August 2023. Identifier: NCT05526053.

The geology and evolution of the Near-Earth binary asteroid system (65803) Didymos.

Images collected during NASA's Double Asteroid Redirection Test (DART) mission provide the first resolved views of the Didymos binary asteroid system. These images reveal that the primary asteroid, Didymos, is flattened and has plausible undulations along its equatorial perimeter. At high elevations, its surface is rough and contains large boulders and craters; at low elevations its surface is smooth and possesses fewer large boulders and craters. Didymos' moon, Dimorphos, possesses an intimate mixture of boulders, several asteroid-wide lineaments, and a handful of craters. The surfaces of both asteroids include boulders that are large relative to their host body, suggesting that both asteroids are rubble piles. Based on these observations, our models indicate that Didymos has a surface cohesion ≤ 1 Pa and an interior cohesion of ∼10 Pa, while Dimorphos has a surface cohesion of <0.9 Pa. Crater size-frequency analyzes indicate the surface age of Didymos is 40-130 times older than Dimorphos, with likely absolute ages of ~ 12.5 Myr and <0.3 Myr, respectively. Solar radiation could have increased Didymos' spin rate leading to internal deformation and surface mass shedding, which likely created Dimorphos.

Activity of Microbial-Derived Phenolic Acids and Their Conjugates against LPS-Induced Damage in Neuroblastoma Cells and Macrophages.

The aim of this study was to investigate whether microbial-derived phenolic acids, 3,4-dihydroxyphenylacetic (DHPA), protocatechuic acid (PCA), and dihydrocaffeic acid (DHCFA) and their conjugated forms (DHCFA 3-O-sulfate and DHCFA 3-O-ß-D-glucuronide), exhibit protective effects against neuroinflammation and oxidative stress. Experiments were performed on human neuronal SH-SY5Y cells stimulated with bacterial lipopolysaccharide (LPS) and tert-butyl hydroperoxide (tBHP). Anti-inflammatory activity in terms of pro-inflammatory cytokine production was also evaluated in LPS-stimulated RAW 264.7 macrophages as a reactive microglial model. Treatment of the SH-SY5Y cells with the free phenolic acids, as well as with the conjugated metabolites, at physiologically concentrations (1, 10 and 50 µM), resulted in increased cell viability of LPS- and tBHP-stimulated cells. Phenolic metabolites and, especially, the conjugated derivatives also protected neuronal cells through significant attenuation of inflammation by decreasing ROS levels. Furthermore, the conjugated and microbial-derived phenolic metabolites significantly inhibited the secretion of proinflammatory cytokines (TNF-α, IL-6, and IL-8) in LPS-stimulated macrophages. Among the phenolic metabolites tested, different efficacies were observed, with the glucuronide form standing out. Overall, these results suggest, for the first time, that conjugated derivatives of phenolic acids seem to be more effective at protecting neurons from inflammation damage and oxidative stress. Further in vivo studies are warranted.

Ventilation support in SARS-CoV-2 pneumonia. Strategy and indications

The SARS-CoV2 pandemic has generated a need forknowledge, new concepts in pathophysiology and an increaseof the use of respiratory support in highly complex patients.This fact has provoked the need to evolve to the concept ofpersonalized ventilatory support according to the patient’s response to treatment. (AU)

Present-day heat flow model of Mars.

Until the acquisition of in-situ measurements, the study of the present-day heat flow of Mars must rely on indirect methods, mainly based on the relation between the thermal state of the lithosphere and its mechanical strength, or on theoretical models of internal evolution. Here, we present a first-order global model for the present-day surface heat flow for Mars, based on the radiogenic heat production of the crust and mantle, on scaling of heat flow variations arising from crustal thickness and topography variations, and on the heat flow derived from the effective elastic thickness of the lithosphere beneath the North Polar Region. Our preferred model finds heat flows varying between 14 and 25 mW m-2, with an average value of 19 mW m-2. Similar results (although about ten percent higher) are obtained if we use heat flow based on the lithospheric strength of the South Polar Region. Moreover, expressing our results in terms of the Urey ratio (the ratio between total internal heat production and total heat loss through the surface), we estimate values close to 0.7-0.75, which indicates a moderate contribution of secular cooling to the heat flow of Mars (consistent with the low heat flow values deduced from lithosphere strength), unless heat-producing elements abundances for Mars are subchondritic.