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1.

Acquisition of epithelial plasticity in human chronic liver disease.

Gribben, Christopher; Galanakis, Vasileios; Calderwood, Alexander; Williams, Eleanor C; Chazarra-Gil, Ruben; Larraz, Miguel; Frau, Carla; Puengel, Tobias; Guillot, Adrien; Rouhani, Foad J; Mahbubani, Krishnaa; Godfrey, Edmund; Davies, Susan E; Athanasiadis, Emmanouil; Saeb-Parsy, Kourosh; Tacke, Frank; Allison, Michael; Mohorianu, Irina; Vallier, Ludovic.

Nature ; 2024 May 22.

Artículo en Inglés | MEDLINE | ID: mdl-38778114

2.

An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH.

Tacke, Frank; Puengel, Tobias; Loomba, Rohit; Friedman, Scott L.

J Hepatol ; 79(2): 552-566, 2023 08.

Artículo en Inglés | MEDLINE | ID: mdl-37061196

3.

Serum CXCL5 Detects Early Hepatocellular Carcinoma and Indicates Tumor Progression.

Laschtowitz, Alena; Lambrecht, Joeri; Puengel, Tobias; Tacke, Frank; Mohr, Raphael.

Int J Mol Sci ; 24(6)2023 Mar 10.

Artículo en Inglés | MEDLINE | ID: mdl-36982370

4.

Nuclear Receptors Linking Metabolism, Inflammation, and Fibrosis in Nonalcoholic Fatty Liver Disease.

Puengel, Tobias; Liu, Hanyang; Guillot, Adrien; Heymann, Felix; Tacke, Frank; Peiseler, Moritz.

Int J Mol Sci ; 23(5)2022 Feb 28.

Artículo en Inglés | MEDLINE | ID: mdl-35269812

5.

Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis.

Puengel, Tobias; Lefere, Sander; Hundertmark, Jana; Kohlhepp, Marlene; Penners, Christian; Van de Velde, Frederique; Lapauw, Bruno; Hoorens, Anne; Devisscher, Lindsey; Geerts, Anja; Boehm, Stephanie; Zhao, Qihong; Krupinski, John; Charles, Edgar D; Zinker, Bradley; Tacke, Frank.

Int J Mol Sci ; 23(12)2022 Jun 15.

Artículo en Inglés | MEDLINE | ID: mdl-35743140

6.

Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis.

Krenkel, Oliver; Hundertmark, Jana; Abdallah, Ali T; Kohlhepp, Marlene; Puengel, Tobias; Roth, Tilmann; Branco, Diogo Philippini Pontual; Mossanen, Jana C; Luedde, Tom; Trautwein, Christian; Costa, Ivan G; Tacke, Frank.

Gut ; 69(3): 551-563, 2020 03.

Artículo en Inglés | MEDLINE | ID: mdl-31076404

7.

Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages^â.

Lefere, Sander; Puengel, Tobias; Hundertmark, Jana; Penners, Christian; Frank, Anna Katharina; Guillot, Adrien; de Muynck, Kevin; Heymann, Felix; Adarbes, Vanessa; Defrêne, Evelyne; Estivalet, Céline; Geerts, Anja; Devisscher, Lindsey; Wettstein, Guillaume; Tacke, Frank.

J Hepatol ; 73(4): 757-770, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32360434

8.

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis.

Krenkel, Oliver; Puengel, Tobias; Govaere, Olivier; Abdallah, Ali T; Mossanen, Jana C; Kohlhepp, Marlene; Liepelt, Anke; Lefebvre, Eric; Luedde, Tom; Hellerbrand, Claus; Weiskirchen, Ralf; Longerich, Thomas; Costa, Ivan G; Anstee, Quentin M; Trautwein, Christian; Tacke, Frank.

Hepatology ; 67(4): 1270-1283, 2018 04.

Artículo en Inglés | MEDLINE | ID: mdl-28940700

9.

Cell type-specific actions of thyroid hormones in nonalcoholic steatohepatitis and liver fibrosis.

Puengel, Tobias; Tacke, Frank.

Liver Int ; 44(2): 275-278, 2024 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-38289588

10.

Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury.

Mossanen, Jana C; Krenkel, Oliver; Ergen, Can; Govaere, Olivier; Liepelt, Anke; Puengel, Tobias; Heymann, Felix; Kalthoff, Sandra; Lefebvre, Eric; Eulberg, Dirk; Luedde, Tom; Marx, Gernot; Strassburg, Christian P; Roskams, Tania; Trautwein, Christian; Tacke, Frank.

Hepatology ; 64(5): 1667-1682, 2016 11.

Artículo en Inglés | MEDLINE | ID: mdl-27302828

11.

Repair macrophages in acute liver failure.

Puengel, Tobias; Tacke, Frank.

Gut ; 67(2): 202-203, 2018 02.

Artículo en Inglés | MEDLINE | ID: mdl-28483781

12.

Efruxifermin, an investigational treatment for fibrotic or cirrhotic nonalcoholic steatohepatitis (NASH).

Puengel, Tobias; Tacke, Frank.

Expert Opin Investig Drugs ; 32(6): 451-461, 2023.

Artículo en Inglés | MEDLINE | ID: mdl-37376813

13.

Cenicriviroc for the treatment of COVID-19: first interim results of a randomised, placebo-controlled, investigator-initiated, double-blind phase II trial.

Kurth, Florian; Helbig, Elisa T; Lippert, Lena J; Thibeault, Charlotte; Barbone, Gianluca; Eckart, Marius A; Kluge, Martin; Puengel, Tobias; Demir, Münevver; Röhle, Robert; Keller, Theresa; Ruwwe-Glösenkamp, Christoph; Witzenrath, Martin; Suttorp, Norbert; von Kalle, Christof; Sander, Leif E; Jochum, Christoph; Tacke, Frank.

J Glob Antimicrob Resist ; 32: 44-47, 2023 03.

Artículo en Inglés | MEDLINE | ID: mdl-36572146

14.

Thyroid hormones as a disease modifier and therapeutic target in nonalcoholic steatohepatitis.

Wirth, Eva K; Puengel, Tobias; Spranger, Joachim; Tacke, Frank.

Expert Rev Endocrinol Metab ; 17(5): 425-434, 2022 09.

Artículo en Inglés | MEDLINE | ID: mdl-35957531

15.

Soluble Urokinase Plasminogen Activator Receptor Levels Are Associated with Severity of Fibrosis in Patients with Primary Sclerosing Cholangitis.

Özdirik, Burcin; Maibier, Martin; Scherf, Maria; Nicklaus, Jule Marie; Frohme, Josephine; Puengel, Tobias; Meyer Zum Büschenfelde, Dirk; Tacke, Frank; Mueller, Tobias; Sigal, Michael.

J Clin Med ; 11(9)2022 Apr 28.

Artículo en Inglés | MEDLINE | ID: mdl-35566603

16.

Monocyte dysregulation: consequences for hepatic infections.

Sellau, Julie; Puengel, Tobias; Hoenow, Stefan; Groneberg, Marie; Tacke, Frank; Lotter, Hannelore.

Semin Immunopathol ; 43(4): 493-506, 2021 08.

Artículo en Inglés | MEDLINE | ID: mdl-33829283

17.

Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients.

Puengel, Tobias; Weber, Beate; Wirtz, Theresa H; Buendgens, Lukas; Loosen, Sven H; Geisler, Lukas; Özdirik, Burcin; Hamesch, Karim; Jhaisha, Samira Abu; Brozat, Jonathan F; Hohlstein, Philipp; Eisert, Albrecht; Yagmur, Eray; Trautwein, Christian; Tacke, Frank; Koch, Alexander.

Diagnostics (Basel) ; 12(1)2021 12 28.

Artículo en Inglés | MEDLINE | ID: mdl-35054232

18.

CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients.

Wirtz, Theresa H; Loosen, Sven H; Schulze-Hagen, Maximilian; Weiskirchen, Ralf; Buendgens, Lukas; Abu Jhaisha, Samira; Brozat, Jonathan F; Puengel, Tobias; Vucur, Mihael; Paffenholz, Pia; Kuhl, Christiane; Tacke, Frank; Trautwein, Christian; Luedde, Tom; Roderburg, Christoph; Koch, Alexander.

PLoS One ; 16(4): e0250321, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-33861804

19.

[Diagnosis and treatment of severe acute pancreatitis in critical care]. / Diagnostik und Therapie der schweren akuten Pankreatitis in der Intensivmedizin.

Wirtz, Theresa H; Puengel, Tobias; Buendgens, Lukas; Luedde, Tom; Trautwein, Christian; Koch, Alexander.

Dtsch Med Wochenschr ; 145(12): 850-862, 2020 06.

Artículo en Alemán | MEDLINE | ID: mdl-32557487

20.

Association of Serum Calprotectin Concentrations with Mortality in Critically Ill and Septic Patients.

Wirtz, Theresa H; Buendgens, Lukas; Weiskirchen, Ralf; Loosen, Sven H; Haehnsen, Nina; Puengel, Tobias; Abu Jhaisha, Samira; Brozat, Jonathan F; Hohlstein, Philipp; Koek, Ger; Eisert, Albrecht; Mohr, Raphael; Roderburg, Christoph; Luedde, Tom; Trautwein, Christian; Tacke, Frank; Koch, Alexander.

Diagnostics (Basel) ; 10(11)2020 Nov 23.

Artículo en Inglés | MEDLINE | ID: mdl-33238644

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Acquisition of epithelial plasticity in human chronic liver disease.

An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH.

Serum CXCL5 Detects Early Hepatocellular Carcinoma and Indicates Tumor Progression.

Nuclear Receptors Linking Metabolism, Inflammation, and Fibrosis in Nonalcoholic Fatty Liver Disease.

Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis.

Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis.

Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages^â.

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis.

Cell type-specific actions of thyroid hormones in nonalcoholic steatohepatitis and liver fibrosis.

Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury.

Repair macrophages in acute liver failure.

Efruxifermin, an investigational treatment for fibrotic or cirrhotic nonalcoholic steatohepatitis (NASH).

Cenicriviroc for the treatment of COVID-19: first interim results of a randomised, placebo-controlled, investigator-initiated, double-blind phase II trial.

Thyroid hormones as a disease modifier and therapeutic target in nonalcoholic steatohepatitis.

Soluble Urokinase Plasminogen Activator Receptor Levels Are Associated with Severity of Fibrosis in Patients with Primary Sclerosing Cholangitis.

Monocyte dysregulation: consequences for hepatic infections.

Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients.

CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients.

[Diagnosis and treatment of severe acute pancreatitis in critical care]. / Diagnostik und Therapie der schweren akuten Pankreatitis in der Intensivmedizin.

Association of Serum Calprotectin Concentrations with Mortality in Critically Ill and Septic Patients.