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1.

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4⁺ T Cells.

Sledzinska, Anna; Vila de Mucha, Maria; Bergerhoff, Katharina; Hotblack, Alastair; Demane, Dafne Franz; Ghorani, Ehsan; Akarca, Ayse U; Marzolini, Maria A V; Solomon, Isabelle; Vargas, Frederick Arce; Pule, Martin; Ono, Masahiro; Seddon, Benedict; Kassiotis, George; Ariyan, Charlotte E; Korn, Thomas; Marafioti, Teresa; Lord, Graham M; Stauss, Hans; Jenner, Richard G; Peggs, Karl S; Quezada, Sergio A.

Immunity ; 52(1): 151-166.e6, 2020 01 14.

Artículo en Inglés | MEDLINE | ID: mdl-31924474

2.

CD19/CD22 targeting with cotransduced CAR T cells to prevent antigen-negative relapse after CAR T-cell therapy for B-cell ALL.

Ghorashian, Sara; Lucchini, Giovanna; Richardson, Rachel; Nguyen, Kyvi; Terris, Craig; Guvenel, Aleks; Oporto-Espuelas, Macarena; Yeung, Jenny; Pinner, Danielle; Chu, Jan; Williams, Lindsey; Ko, Ka-Yuk; Walding, Chloe; Watts, Kelly; Inglott, Sarah; Thomas, Rebecca; Connor, Christopher; Adams, Stuart; Gravett, Emma; Gilmour, Kimberly; Lal, Alka; Kunaseelan, Sangeetha; Popova, Bilyana; Lopes, Andre; Ngai, Yenting; Hackshaw, Allan; Kokalaki, Evangelia; Carulla, Milena Balasch; Mullanfiroze, Khushnuma; Lazareva, Arina; Pavasovic, Vesna; Rao, Anupama; Bartram, Jack; Vora, Ajay; Chiesa, Robert; Silva, Juliana; Rao, Kanchan; Bonney, Denise; Wynn, Robert; Pule, Martin; Hough, Rachael; Amrolia, Persis J.

Blood ; 143(2): 118-123, 2024 Jan 11.

Artículo en Inglés | MEDLINE | ID: mdl-37647647

3.

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.

Arce Vargas, Frederick; Furness, Andrew J S; Solomon, Isabelle; Joshi, Kroopa; Mekkaoui, Leila; Lesko, Marta H; Miranda Rota, Enrique; Dahan, Rony; Georgiou, Andrew; Sledzinska, Anna; Ben Aissa, Assma; Franz, Dafne; Werner Sunderland, Mariana; Wong, Yien Ning Sophia; Henry, Jake Y; O'Brien, Tim; Nicol, David; Challacombe, Ben; Beers, Stephen A; Turajlic, Samra; Gore, Martin; Larkin, James; Swanton, Charles; Chester, Kerry A; Pule, Martin; Ravetch, Jeffrey V; Marafioti, Teresa; Peggs, Karl S; Quezada, Sergio A.

Immunity ; 46(4): 577-586, 2017 04 18.

Artículo en Inglés | MEDLINE | ID: mdl-28410988

4.

Dual targeting of CD19 and CD22 with bicistronic CAR-T cells in patients with relapsed/refractory large B-cell lymphoma.

Roddie, Claire; Lekakis, Lazaros J; Marzolini, Maria A V; Ramakrishnan, Aravind; Zhang, Yiyun; Hu, Yanqing; Peddareddigari, Vijay G R; Khokhar, Nushmia; Chen, Robert; Basilico, Silvia; Raymond, Meera; Vargas, Frederick Arce; Duffy, Kevin; Brugger, Wolfram; O'Reilly, Maeve A; Wood, Leigh; Linch, David C; Peggs, Karl S; Bachier, Carlos; Budde, Elizabeth Lihua; Lee Batlevi, Connie; Bartlett, Nancy; Irvine, David; Tholouli, Eleni; Osborne, Wendy; Ardeshna, Kirit M; Pule, Martin A.

Blood ; 141(20): 2470-2482, 2023 05 18.

Artículo en Inglés | MEDLINE | ID: mdl-36821767

5.

Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia.

Maciocia, Paul M; Wawrzyniecka, Patrycja A; Maciocia, Nicola C; Burley, Amy; Karpanasamy, Thaneswari; Devereaux, Sam; Hoekx, Malika; O'Connor, David; Leon, Theresa; Rapoz-D'Silva, Tanya; Pocock, Rachael; Rahman, Sunniyat; Gritti, Giuseppe; Yánez, Diana C; Ross, Susan; Crompton, Tessa; Williams, Owen; Lee, Lydia; Pule, Martin A; Mansour, Marc R.

Blood ; 140(1): 25-37, 2022 07 07.

Artículo en Inglés | MEDLINE | ID: mdl-35507686

6.

Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR.

Kokalaki, Evangelia; Ma, Biao; Ferrari, Mathieu; Grothier, Thomas; Hazelton, Warren; Manzoor, Somayya; Costu, Eren; Taylor, Julia; Bulek, Anna; Srivastava, Saket; Gannon, Isaac; Jha, Ram; Gealy, Rosalind; Stanczuk, Lukas; Rizou, Tatiana; Robson, Mathew; El-Kholy, Mohamed; Baldan, Vania; Righi, Matteo; Sillibourne, James; Thomas, Simon; Onuoha, Shimobi; Cordoba, Shaun; Pule, Martin.

Mol Ther ; 31(7): 2089-2104, 2023 07 05.

Artículo en Inglés | MEDLINE | ID: mdl-36945773

7.

Characterization of a Novel ACE2-Based Therapeutic with Enhanced Rather than Reduced Activity against SARS-CoV-2 Variants.

Ferrari, Mathieu; Mekkaoui, Leila; Ilca, F Tudor; Akbar, Zulaikha; Bughda, Reyisa; Lamb, Katarina; Ward, Katarzyna; Parekh, Farhaan; Karattil, Rajeev; Allen, Christopher; Wu, Philip; Baldan, Vania; Mattiuzzo, Giada; Bentley, Emma M; Takeuchi, Yasuhiro; Sillibourne, James; Datta, Preeta; Kinna, Alexander; Pule, Martin; Onuoha, Shimobi C.

J Virol ; 95(19): e0068521, 2021 09 09.

Artículo en Inglés | MEDLINE | ID: mdl-34287040

8.

An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma.

Lee, Lydia; Draper, Benjamin; Chaplin, Neil; Philip, Brian; Chin, Melody; Galas-Filipowicz, Daria; Onuoha, Shimobi; Thomas, Simon; Baldan, Vania; Bughda, Reyisa; Maciocia, Paul; Kokalaki, Eva; Neves, Margarida P; Patel, Dominic; Rodriguez-Justo, Manuel; Francis, James; Yong, Kwee; Pule, Martin.

Blood ; 131(7): 746-758, 2018 02 15.

Artículo en Inglés | MEDLINE | ID: mdl-29284597

9.

Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR.

Kokalaki, Evangelia; Ma, Biao; Ferrari, Mathieu; Grothier, Thomas; Hazelton, Warren; Manzoor, Somayya; Costu, Eren; Taylor, Julia; Bulek, Anna; Srivastava, Saket; Gannon, Isaac; Jha, Ram; Gealy, Rosalind; Stanczuk, Lukas; Rizou, Tatiana; Robson, Mathew; El-Kholy, Mohamed; Baldan, Vania; Righi, Matteo; Sillibourne, James; Thomas, Simon; Onuoha, Shimobi; Cordoba, Shaun; Pule, Martin.

Mol Ther ; 32(2): 556-558, 2024 Feb 07.

Artículo en Inglés | MEDLINE | ID: mdl-38103549

10.

A Rapamycin-Activated Caspase 9-Based Suicide Gene.

Stavrou, Maria; Philip, Brian; Traynor-White, Charlotte; Davis, Christopher G; Onuoha, Shimobi; Cordoba, Shaun; Thomas, Simon; Pule, Martin.

Mol Ther ; 26(5): 1266-1276, 2018 05 02.

Artículo en Inglés | MEDLINE | ID: mdl-29661681

11.

Siglec-6 CAR T: magic bullet for a moving target.

Ghorashian, Sara; Pule, Martin.

Blood ; 138(19): 1786-1787, 2021 11 11.

Artículo en Inglés | MEDLINE | ID: mdl-34762132

12.

Evolving adoptive cellular therapies in urological malignancies.

Wong, Yien Ning Sophia; Joshi, Kroopa; Pule, Martin; Peggs, Karl S; Swanton, Charles; Quezada, Sergio A; Linch, Mark.

Lancet Oncol ; 18(6): e341-e353, 2017 06.

Artículo en Inglés | MEDLINE | ID: mdl-28593860

13.

TALEN-mediated genetic inactivation of the glucocorticoid receptor in cytomegalovirus-specific T cells.

Menger, Laurie; Gouble, Agnes; Marzolini, Maria A V; Pachnio, Annette; Bergerhoff, Katharina; Henry, Jake Y; Smith, Julianne; Pule, Martin; Moss, Paul; Riddell, Stanley R; Quezada, Sergio A; Peggs, Karl S.

Blood ; 126(26): 2781-9, 2015 Dec 24.

Artículo en Inglés | MEDLINE | ID: mdl-26508783

14.

Treatment of diffuse large B-cell lymphoma with secondary central nervous system involvement: encouraging efficacy using CNS-penetrating R-IDARAM chemotherapy.

Maciocia, Paul; Badat, Mohsin; Cheesman, Simon; D'Sa, Shirley; Joshi, Rahul; Lambert, Jonathan; Mohamedbhai, Sajir; Pule, Martin; Linch, David; Ardeshna, Kirit.

Br J Haematol ; 172(4): 545-53, 2016 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-26684148

15.

Anti-CD1a CAR T cells to selectively target T-ALL.

Maciocia, Paul M; Pule, Martin A.

Blood ; 133(21): 2246-2247, 2019 05 23.

Artículo en Inglés | MEDLINE | ID: mdl-31122936

16.

Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells.

Ricciardelli, Ida; Blundell, Michael Patrick; Brewin, Jennifer; Thrasher, Adrian; Pule, Martin; Amrolia, Persis J.

Blood ; 124(16): 2514-22, 2014 Oct 16.

Artículo en Inglés | MEDLINE | ID: mdl-25185261

17.

A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy.

Philip, Brian; Kokalaki, Evangelia; Mekkaoui, Leila; Thomas, Simon; Straathof, Karin; Flutter, Barry; Marin, Virna; Marafioti, Teresa; Chakraverty, Ronjon; Linch, David; Quezada, Sergio A; Peggs, Karl S; Pule, Martin.

Blood ; 124(8): 1277-87, 2014 Aug 21.

Artículo en Inglés | MEDLINE | ID: mdl-24970931

18.

Automated manufacturing of chimeric antigen receptor T cells for adoptive immunotherapy using CliniMACS prodigy.

Mock, Ulrike; Nickolay, Lauren; Philip, Brian; Cheung, Gordon Weng-Kit; Zhan, Hong; Johnston, Ian C D; Kaiser, Andrew D; Peggs, Karl; Pule, Martin; Thrasher, Adrian J; Qasim, Waseem.

Cytotherapy ; 18(8): 1002-1011, 2016 08.

Artículo en Inglés | MEDLINE | ID: mdl-27378344

19.

Trafficking of CAR T cells to sites of subclinical leukaemia cutis.

O'Reilly, Maeve; Roddie, Claire; Marzolini, Maria A V; Rodriguez-Justo, Manuel; Pomplun, Sabine; Pule, Martin; Peggs, Karl S.

Lancet Oncol ; 21(3): e179, 2020 03.

Artículo en Inglés | MEDLINE | ID: mdl-32135121

20.

CD19 chimeric antigen receptor T cell therapy for haematological malignancies.

Ghorashian, Sara; Pule, Martin; Amrolia, Persis.

Br J Haematol ; 169(4): 463-78, 2015 May.

Artículo en Inglés | MEDLINE | ID: mdl-25753571

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Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4⁺ T Cells.

CD19/CD22 targeting with cotransduced CAR T cells to prevent antigen-negative relapse after CAR T-cell therapy for B-cell ALL.

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.

Dual targeting of CD19 and CD22 with bicistronic CAR-T cells in patients with relapsed/refractory large B-cell lymphoma.

Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia.

Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR.

Characterization of a Novel ACE2-Based Therapeutic with Enhanced Rather than Reduced Activity against SARS-CoV-2 Variants.

An APRIL-based chimeric antigen receptor for dual targeting of BCMA and TACI in multiple myeloma.

Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR.

A Rapamycin-Activated Caspase 9-Based Suicide Gene.

Siglec-6 CAR T: magic bullet for a moving target.

Evolving adoptive cellular therapies in urological malignancies.

TALEN-mediated genetic inactivation of the glucocorticoid receptor in cytomegalovirus-specific T cells.

Treatment of diffuse large B-cell lymphoma with secondary central nervous system involvement: encouraging efficacy using CNS-penetrating R-IDARAM chemotherapy.

Anti-CD1a CAR T cells to selectively target T-ALL.

Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells.

A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy.

Automated manufacturing of chimeric antigen receptor T cells for adoptive immunotherapy using CliniMACS prodigy.

Trafficking of CAR T cells to sites of subclinical leukaemia cutis.

CD19 chimeric antigen receptor T cell therapy for haematological malignancies.