[Extracorporeal CO2 removal as an alternative to tracheotomy in a patient with extubation failure]. / Extrakorporale CO2-Elimination als Alternative zur Tracheotomie bei Weaningversagen.

We report a patient with chest trauma who was admitted to the ICU after surgery. As he fulfilled protocol-based criteria, he was extubated 7 days after admission. However, despite intermittent non-invasive ventilation, the patient had to be re-intubated on day 10 owing to progressive hypercapnia. We decided to support the patient with a mid-flow veno-venous extracorporeal carbon dioxide removal (ECCO2­R) system instead of a tracheotomy. Sufficient CO2 removal was established with a blood flow of 1.5 l/min and the patient was successfully extubated within a few hours. After 5 days of ECCO2­R the patient could be weaned and transferred to a general ward in a stable condition.

[Indications and outcome of ventilated patients treated in a neurological intensive care unit]. / Indikationen und Outcome beatmeter Patienten einer neurologischen Intensivstation.

OBJECTIVE: This study characterized artificially ventilated patients in a neurological intensive care unit (NICU) between 2006-2008 in a purely neurological clinic and a so-called stand-alone situation. In addition the long-term prognoses as well as the quality of life of surviving patients were investigated. METHODS: All ventilated patients from October 2006 to December 2008 were enrolled in this descriptive, retrospective study. The duration of stay in intensive care was analyzed and the current quality of life was prospectively assessed based on the patient records. Final diagnoses, duration of intensive care unit and ventilation as well as the highest score in SAPS II (simplified acute physiology score) and complications during hospitalization were determined. The patients were divided into groups based on the diagnoses as vascular, inflammatory, neurodegenerative, hereditary, epileptogenic and others. Additionally patients were contacted and asked to respond by completing questionnaires on the Barthel index (BI) and the modified Rankin scale (mRS). RESULTS: During the study period a total of 512 patients were treated in the NICU of whom 201 required artificial respiration. Cerebrovascular diseases were the main reason for therapy in the NICU in 96 out of 201 cases (47.8%), followed by inflammatory diseases in 46 (22.8%) and epileptogenic diseases in 26 patients (13%). The median duration of artificial respiration was 9 days with a mean treatment duration of 16 days (range 1-57 days). Of the patients 31 (15.4%) died in the NICU and an additional 32 patients (18.8%) died within a median of 2 months after discharge. Outcome data were available from 67 out of 170 sent questionnaires and rehabilitation reports of 86 patients, which enabled the outcome of 121 surviving patients to be analyzed (71.2%). Of these 42.2% showed no or mild impairment in everyday life. However, the remaining 38% had severe impairments according to the BI. The evaluation of the mRS showed that 49.6% of the patients still had severe symptoms. CONCLUSIONS: More than one third of the patients treated in the NICU required artificial ventilation with an emphasis on cerebrovascular diseases, which illustrates the overlap between stroke unit and NICU care. Despite a lengthy duration of ventilation and a long stay in the intensive care unit more than one third of surviving patients showed no or only mild impairment. However, an additional third suffered from severe disability up to nursing care dependency. The study data differ little from the few publications in this field despite the stand alone situation of the NICU. The case mix index per day averaged around 0.3 and underlines the economic importance with respect to other forms of neurological treatment.

Diversity of the basic defect of homozygous CFTR mutation genotypes in humans.

BACKGROUND: Knowledge of how CFTR mutations other than F508del translate into the basic defect in cystic fibrosis (CF) is scarce due to the low incidence of homozygous index cases. METHODS: 17 individuals who are homozygous for deletions, missense, stop or splice site mutations in the CFTR gene were investigated for clinical symptoms of CF and assessed in CFTR function by sweat test, nasal potential difference and intestinal current measurement. RESULTS: CFTR activity in sweat gland, upper airways and distal intestine was normal for homozygous carriers of G314E or L997F and in the range of F508del homozygotes for homozygous carriers of E92K, W1098L, R553X, R1162X, CFTRdele2(ins186) or CFTRdele2,3(21 kb). Homozygotes for M1101K, 1898+3 A-G or 3849+10 kb C-T were not consistent CF or non-CF in the three bioassays. 14 individuals exhibited some chloride conductance in the airways and/or in the intestine which was identified by the differential response to cAMP and DIDS as being caused by CFTR or at least two other chloride conductances. DISCUSSION: CFTR mutations may lead to unusual electrophysiological or clinical manifestations. In vivo and ex vivo functional assessment of CFTR function and in-depth clinical examination of the index cases are indicated to classify yet uncharacterised CFTR mutations as either disease-causing lesions, risk factors, modifiers or neutral variants.

Measuring depth of sedation in intensive care patients with the electroencephalographic Narcotrend Index.

BACKGROUND AND OBJECTIVE: The electroencephalographic Narcotrend Index was evaluated as a measure of sedation in mechanically ventilated intensive care unit patients. Narcotrend Index and conventional electroencephalography parameter values were compared to the Richmond Agitation-Sedation Scale and a simplified three-level sedation scale. METHODS: In all, 100 mechanically ventilated patients, admitted to the cardiac surgical intensive care unit after open-heart surgery, were enrolled in this prospective observational study. The Narcotrend Index was recorded while patients were either sedated by propofol infusion or without sedative medication while being weaned off the ventilator. Clinical assessment of the patients' level of sedation was performed by means of the Richmond Agitation-Sedation Scale by a single observer who was blinded to the Narcotrend Index. RESULTS: With the six-level Richmond Agitation-Sedation Scale, the prediction probability (PK) for the Narcotrend Index (0.81) was better than for all other electroencephalography parameters (P < 0.01) except for relative power in the beta band (PK 0.75). Using the three-level sedation scale instead, PK values for the Narcotrend Index (0.88) and all electroencephalography parameters improved (P < 0.01), and the Narcotrend Index was now superior to all electroencephalography parameters. Narcotrend Index values were distributed among the various sedation levels with significant overlap. CONCLUSION: When used for assessment of propofol sedation in postsurgical cardiac intensive care unit patients, the Narcotrend Index can distinguish between very light and deep sedation. With respect to differentiation between light and moderate or moderate and deep sedation, the Narcotrend Index was not reliable in this study.

[Positioning therapy in intensive care medicine in Germany. Results of a national survey]. / Einsatz der Lagerungstherapie auf deutschen Intensivstationen. Ergebnisse einer Umfrage.

BACKGROUND: The effects of a systematic change in a patient's position [prone position, continuous lateral rotational therapy (CLRT)] have been investigated in recent years in acute lung injury and have shown an improvement in oxygenation, but controversial results regarding duration of mechanical ventilation, intensive care treatment and mortality compared to conventionally treated patients. We were interested in the practice and acceptance of positioning therapy in German intensive care units (ICU) and performed a national postal survey with respect to evaluation of indications, preference of particular positions, observed complications and additional aspects (costs, influence on other intensive care measures etc.). METHODS: A questionnaire (12 multiple choice items) was sent to 1,763 ICUs, which were identified from the "Deutsches Krankenhausadressbuch" (German hospital address book 2005). The analysis was performed anonymously. RESULTS: A total of 702 questionnaires (40.4%) were returned and analysed. The 135 degrees position (incomplete prone position) was most frequently used (50%), while the prone position (25%) and CLRT (18%) were less frequent. The improvement in oxygenation (95%) and the prevention of ventilator-associated complications (75.7%) were important indications for positioning therapy. Results of a blood gas analysis provided the necessary criteria for determining positional therapy. Supporters of the prone position advocated lower cost and better efficacy in comparison to CLRT. The frequency of complications during positioning therapy was reported to be high: hemodynamic instability (73.6%), accidental loss of tube/catheters (50.4%) and patient intolerance (40.7%) were often observed, and complication-free positioning therapy was reported in only 8.6%. CONCLUSIONS: The 135 degrees position (incomplete prone position) is the most frequently used positioning therapy in Germany for improvement of oxygenation in patients with acute lung injury. Prone position and CLRT are less frequently used, probably due to an increased frequency of (expected) complications. The authors assume that clear guidelines and algorithms are needed to establish a more routine, safe practical application and a reduction in the complication rate.

[Cerebral monitoring in carotid surgery. Results of a questionnaire in the Federal Republic of Germany]. / Zerebrale Uberwachungsmassnahmen in der Karotischirurgie - Ergebnisse einer Umfrage in der Bundesrepublik Deutschland -

A standardized questionnaire was used to find out if and what kind of intraoperative cerebral monitoring method, respectively, is practised for carotid surgery in Germany. Out of 351 hospitals having received the questionnaire, 251 (75.1 %) answered the questions. 43 hospitals had not performed any carotid surgery in 1998, so 208 questionnaires remained for further analysis. In 43.3 % (n = 90), hospitals did not practise any kind of cerebral monitoring. In contrast, most hospitals monitored cerebral function and/or cerebral haemodynamics, intraoperatively. Median nerve somatosensory evoked potentials (SEP; n = 60) and electroencephalography (EEG; n = 39) dominated, whereas carotid stump pressure measuring (n = 40), transcranial Doppler sonography (TCD; n = 10), cerebral venous oximetry (n = 8) and near-infrared spectroscopy (n = 4) were used less frequently. In 60 hospitals, the indication to install temporary intraluminal shunting was based primarily on monitoring results. The results of our study mirror the present practice of intraoperative cerebral monitoring for carotid surgery in Germany. SEP monitoring is preferable because this method can reveal an imminent cerebral ischaemia with high sensitivity and specifity. TCD and cerebral oximetry are less suitable for this purpose. Measuring carotid stump pressure is not recommendable to reflect the status of cerebral haemodynamics, however this method is still in frequent use. Recommendations whether to practise cerebral monitoring or not, and what method should be used for this purpose, cannot be given presently.

[Anesthesia in mitochondrial encephalomyopathies]. / Anästhesie bei mitochondrialer Encephalomyopathie.

A 6-year-old boy with a rare mitochondrial disease (MELAS: mitochondrial encephalopathy, lactic acidosis, stroke-like episodes) was presented to undergo adenoid resection and bilateral paracentesis. ENT surgery was performed without complications under general anaesthesia using propofol, fentanyl, and ventilation with nitrous oxide and oxygen. Routine intraoperative monitoring (ECG, noninvasive blood pressure, oxymetry and capnometry) was supplemented by frequent body temperature measurements and repeated laboratory analysis of venous blood gases, lactate, and glucose. Clinically, the postoperative course was uneventful and the boy was discharged from hospital on the first postoperative day. Signs or symptoms of malignant hyperthermia never occurred. Laboratory analysis only showed a remarkable serum lactate elevation postoperatively (6 mmol/l) which decreased on the first postoperative day (3.7 mmol/l). The present anaesthesiologic experiences with MELAS-syndrome are limited, and recommendations are mainly based on case reports. Careful preoperative physical examination with special regard to all available medical records, and anaesthetic management comparable with that in malignant hyperthermia susceptible resulted in an uneventful course in our patient. Pathogenetic aspects of mitochondrial diseases focussing on anaesthetic considerations are briefly discussed.