Prevalence of urologic sequelae and bladder and bowel dysfunctions in patients with congenital Zika syndrome: A multicenter evaluation of the Zika virus bladder and bowel sequelae assistance network.

INTRODUCTION: Neurogenic bladder was first confirmed as a urological sequela of Congenital Zika Syndrome (CZS) in 2018. Further clinical-epidemiological evidence also confirmed neurogenic bowel dysfunction and cryptorchidism. To strengthen the care for these children, the Congenital Zika Virus Bladder and Bowel Sequelae Network (RASZ in Brazilian) was created, including six integrated centers in Brazil. This article represents the initial outcome of the efforts by RASZ. OBJECTIVE: To evaluate the prevalence of bladder and bowel dysfunction, cryptorchidism and other urological sequelae related to CZS in cohorts attended in six Brazilian states. STUDY DESIGN: Observational, prospective, multicenter study including children with CZS assisted in one of six RASZ collaborative centers between June 2016 and February 2023. Data were collected from patient's first assessment using the same protocols for urological and bowel evaluation. Categorical variables were analyzed by frequency of occurrence and numerical variables by mean, median, and standard deviation. The study was approved by the Research Ethics Committees of each center, all parents/caregivers provided written informed consent. RESULTS: The study included 414 children aged 2 months to 7 years (mean 2.77 years, SD 1.73), 227 (54.8 %) were male and 140 (33,8 %) referred urological and bowel symptoms on arrival. Prevalence of both urological and bowel sequelae was 66.7 %, 51 % of children aged 4 years and older had urinary incontinence (UI). UTI was confirmed in 23.4 % (two presented toxemia) and among males, 18.1 % had cryptorchidism. Renal ultrasonography, performed in 186 children, was abnormal in 25 (13.4 %), 7 had hydronephrosis. Among the 287 children who performed urodynamics, 283 (98.6 %) were altered: 232 had a lower bladder capacity, 144 a maximum bladder pressure of ≥40 cm H2O, and 127 did not satisfactorily empty their bladder. DISCUSSION: A higher prevalence of NLUTD, neurogenic bowel and cryptorchidism was confirmed in children with CZS. Early diagnosis and appropriate treatment, including a multidisciplinary approach, may reduce the risk of UTIs, UI and kidney damage. A limitation of the study was the inability of children to complete the protocol, specifically urodynamic evaluation, and ultrasonography. In both exams, the percentage of abnormal cases was higher than that expected in the normal population. CONCLUSION: A 66,7 % prevalence of combined urological sequelae and bladder-bowel dysfunction related to CZS was confirmed in patients evaluated in six Brazilian cohorts. The most frequent changes were related to NLUTD, neurogenic bowel, and cryptorchidism. Prevalence may be underestimated due to access restrictions to diagnostic tests.

Effects of water- and land-based exercises on quality of life and physical aspects in women with fibromyalgia: A randomized clinical trial.

INTRODUCTION: Fibromyalgia (FM) is consistently associated with fatigue, sleep disturbances, morning stiffness, and anxiety and depression, affecting physical capacities and skills and thereby reducing quality of life. The aim of this study was to compare the effects of water-based and land-based therapies as an adjuvant treatment for women with FM in relation to quality of life and physical aspects. METHODS: FM women were randomized into a water-based exercise group (WG) and land-based exercise group (LG). The interventions were conducted for 8 weeks, three times a week, and each therapy session had a 60-min duration. Evaluations were performed before and after intervention using the Fibromyalgia Impact Questionnaire, the Visual Analogue Scale, the number of tender points (TPs), and the Wells bench sit and reach test score. RESULTS: Both interventions produced significantly positive clinical effects in most aspects evaluated. However, only WG obtained significant improvements for the variables functional capacity, number of TPs, and flexibility. CONCLUSIONS: The findings suggest that water-based exercise is effective as an adjuvant FM treatment, including FM-related physical and psychological health aspects.

Evidence of validity of the Stress-Producing Life Events (SPLE) instrument.

OBJECTIVE Evaluate the construct validity of a list of eight Stressful Life Events in pregnant women. METHODS A cross-sectional study was conducted with 1,446 pregnant women in São Luís, MA, and 1,364 pregnant women in Ribeirão Preto, SP (BRISA cohort), from February 2010 to June 2011. In the exploratory factorial analysis, the promax oblique rotation was used and for the calculation of the internal consistency, we used the compound reliability. The construct validity was determined by means of the confirmatory factorial analysis with the method of estimation of weighted least squares adjusted by the mean and variance. RESULTS The model with the best fit in the exploratory analysis was the one that retained three factors with a cumulative variance of 61.1%. The one-factor model did not obtain a good fit in both samples in the confirmatory analysis. The three-factor model called Stress-Producing Life Events presented a good fit (RMSEA < 0.05; CFI/TLI > 0.90) for both samples. CONCLUSIONS The Stress-Producing Life Events constitute a second order construct with three dimensions related to health, personal and financial aspects and violence. This study found evidence that confirms the construct validity of a list of stressor events, entitled Stress-Producing Life Events Inventory.

Evidence of validity of the stress-producing life events (SPLE) instrument / Evidências de validade do instrumento eventos de vida produtores de estresse (EVPE)

ABSTRACT OBJECTIVE Evaluate the construct validity of a list of eight Stressful Life Events in pregnant women. METHODS A cross-sectional study was conducted with 1,446 pregnant women in São Luís, MA, and 1,364 pregnant women in Ribeirão Preto, SP (BRISA cohort), from February 2010 to June 2011. In the exploratory factorial analysis, the promax oblique rotation was used and for the calculation of the internal consistency, we used the compound reliability. The construct validity was determined by means of the confirmatory factorial analysis with the method of estimation of weighted least squares adjusted by the mean and variance. RESULTS The model with the best fit in the exploratory analysis was the one that retained three factors with a cumulative variance of 61.1%. The one-factor model did not obtain a good fit in both samples in the confirmatory analysis. The three-factor model called Stress-Producing Life Events presented a good fit (RMSEA < 0.05; CFI/TLI > 0.90) for both samples. CONCLUSIONS The Stress-Producing Life Events constitute a second order construct with three dimensions related to health, personal and financial aspects and violence. This study found evidence that confirms the construct validity of a list of stressor events, entitled Stress-Producing Life Events Inventory.

RESUMO OBJETIVO Avaliar a validade de construto de uma lista com oito Eventos de Vida Estressantes em gestantes. MÉTODOS Foi conduzido um estudo transversal com 1.446 gestantes em São Luís, MA, e 1.364 em Ribeirão Preto, SP (coorte BRISA), de fevereiro de 2010 a junho de 2011. Na análise fatorial exploratória, utilizou-se a rotação oblíqua promax e para o cálculo da consistência interna, a confiabilidade composta. A validade de construto foi determinada por meio da análise fatorial confirmatória com o método de estimação dos mínimos quadrados ponderados ajustados pela média e variância. RESULTADOS O modelo com o melhor ajuste na análise exploratória foi o que reteve três fatores com uma variância acumulada de 61,1%. O modelo com um fator não obteve um bom ajuste em ambas as amostras na análise confirmatória. O modelo com três fatores denominado Eventos de Vida Produtores de Estresse apresentou um bom ajuste (RMSEA < 0,05; CFI/TLI > 0,90) para as duas amostras. CONCLUSÕES Os Eventos de Vida Produtores de Estresse constituem um construto de segunda ordem com três dimensões relacionadas à saúde, aos aspectos pessoais e financeiros e à violência. Este estudo encontrou evidências que confirmam a validade de construto de uma lista de eventos estressores, intitulado Inventário de Eventos de Vida Produtores de Estresse.

[Conceptual, item, and semantic equivalence of the Brazilian version of the Dysfunctional Voiding Scoring System (DVSS) instrument for evaluating lower urinary tract dysfunction in children]. / Equivalência conceitual, de itens e semântica da versão brasileira do instrumento Dysfunctional Voiding Scoring System (DVSS) para avaliação de disfunção do trato urinário inferior em crianças.

This article investigates the conceptual, item, and semantic equivalence between the Dysfunctional Voiding Scoring System (DVSS) originally developed in English and a Portuguese-language version for use in Brazil. The instrument is used to evaluate lower urinary tract dysfunction in children. The first stage evaluated the conceptual and item equivalence, followed by two independent translations of the original instrument into Portuguese. In the second stage, 63 individuals were interviewed and items were modified according to difficulties in interpretation. In the third stage, the Portuguese instrument was back-translated into English, and the semantic equivalence was evaluated, based on referential and general (connotative) meaning. In the fourth stage, the pre-test version of the instrument was applied to 20 individuals from the target population. The Portuguese version of the instrument is presented with conceptual, item, and semantic equivalence. Nevertheless, unlike the original instrument, DVSS information collection was more adequate for the Brazilian population when performed through interviews as compared to self-applied questionnaires.

Equivalência conceitual, de itens e semântica da versão brasileira do instrumento Dysfunctional Voiding Scoring System (DVSS) para avaliação de disfunção do trato urinário inferior em crianças / Conceptual, item, and semantic equivalence of the Brazilian version of the Dysfunctional Voiding Scoring System (DVSS) instrument for evaluating lower urinary tract dysfunction in children

Investiga-se a equivalência conceitual, de itens e semântica entre o instrumento Dysfunctional Voiding Scoring System (DVSS), utilizado para avaliar a disfunção funcional do trato urinário inferior em crianças, concebido em inglês e uma versão em português. Na primeira etapa realizou-se a avaliação da equivalência conceitual e de itens, seguida de duas traduções do instrumento original para o português. Na segunda etapa foram realizadas 63 entrevistas, com crianças de 3 a 10 anos e responsáveis, e modificação de itens segundo dificuldades de interpretação. Na terceira etapa foi realizada a retradução do instrumento em português para o inglês e avaliação da equivalência semântica. Na quarta etapa, a versão pré-teste foi aplicada em vinte duplas de crianças de 3 a 10 anos e responsáveis. Apresenta-se o instrumento em português com equivalência conceitual, de itens e semântica. Sugere-se que a aplicação do DVSS seja realizada por meio de entrevista por profissional treinado e não baseada em autopreenchimento como proposto no instrumento original.

This article investigates the conceptual, item, and semantic equivalence between the Dysfunctional Voiding Scoring System (DVSS) originally developed in English and a Portuguese-language version for use in Brazil. The instrument is used to evaluate lower urinary tract dysfunction in children. The first stage evaluated the conceptual and item equivalence, followed by two independent translations of the original instrument into Portuguese. In the second stage, 63 individuals were interviewed and items were modified according to difficulties in interpretation. In the third stage, the Portuguese instrument was back-translated into English, and the semantic equivalence was evaluated, based on referential and general (connotative) meaning. In the fourth stage, the pre-test version of the instrument was applied to 20 individuals from the target population. The Portuguese version of the instrument is presented with conceptual, item, and semantic equivalence. Nevertheless, unlike the original instrument, DVSS information collection was more adequate for the Brazilian population when performed through interviews as compared to self-applied questionnaires.