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1.
Childs Nerv Syst ; 2024 Jun 28.
Artículo en Inglés | MEDLINE | ID: mdl-38940955

RESUMEN

OBJECTIVE: The purpose of this study was to evaluate the surgical complications of patients treated for nonsyndromic sagittal craniosynostosis and the necessity for reoperations due to craniocerebral disproportion. MATERIALS AND METHODS: The patient cohort of this study consisted of patients (N = 82) who were treated in the Oulu University Hospital using the open vault cranioplasty with a modified H-technique between the years 2008 to 2022. There were 69 males (84.1%) and 13 females (15.9%). The mean age at the primary operation was 6.1 months. Mean follow-up time was 9.0 years. RESULTS: There were no major complications related to the procedures. Two patients (2.4%) had a minor dural lesion. There were no postoperative wound infections. Of the 82 patients, seven patients with primary craniosynostosis (13.0%) developed symptomatic craniocerebral disproportion requiring reoperation to increase intracranial volume. In all these patients, invasive intracranial pressure (ICP) monitoring was performed prior to decision-making. In the majority of cases, the aesthetical outcome was considered good or excellent. CONCLUSION: The operative method used was feasible and safe. Thirteen percent of patients who were followed over 5 years required major surgery due to development of craniocerebral disproportion later in life.

2.
Childs Nerv Syst ; 39(5): 1277-1282, 2023 05.
Artículo en Inglés | MEDLINE | ID: mdl-36752911

RESUMEN

PURPOSE: The aim of this case-control study was to investigate occlusal characteristics, received orthodontic treatment, oral health-related quality of life (OHRQoL), and satisfaction with dental esthetics in adults operated due to sagittal synostosis. METHODS: The study group consisted of 40 adults (25 males, 15 females, mean age 27.4 years, range 18-41) who were operated due to isolated sagittal synostosis in childhood. The control group comprised 40 age and gender-matched adults. Occlusal characteristics were evaluated clinically during study visits. Information on the previous orthodontic treatment was collected from dental records. OHRQoL was measured using the 14-item Oral Health Impact Profile (OHIP-14), and satisfaction with dental esthetics was evaluated using a visual analogue scale. RESULTS: No statistically significant differences were found between the patient group and the controls in malocclusion traits (overjet, overbite, molar relationships, crossbite, scissor bite), previous orthodontic treatment, pre-treatment malocclusion diagnoses, OHIP variables, or satisfaction with dental esthetics. However, there was a tendency toward increased overjet and overbite in scaphocephalic patients. CONCLUSION: It seems that adults with scaphocephaly operated in childhood do not differ from the average population in terms of occlusion, received orthodontic treatment, or oral health-related well-being.


Asunto(s)
Craneosinostosis , Maloclusión Clase II de Angle , Maloclusión , Sobremordida , Masculino , Femenino , Humanos , Adulto , Adolescente , Adulto Joven , Sobremordida/terapia , Estudios de Seguimiento , Calidad de Vida , Estudios de Casos y Controles , Maloclusión/cirugía , Maloclusión/epidemiología , Maloclusión Clase II de Angle/epidemiología
3.
Childs Nerv Syst ; 38(12): 2371-2374, 2022 12.
Artículo en Inglés | MEDLINE | ID: mdl-36287258

RESUMEN

Shaken baby syndrome (SBS) is a challenging condition from both a medical and legal perspective. The path of the patients differs significantly from those with noninflicted traumas. While treating these cases, it is essential that all history, information and treatment are comprehensively documented. This article describes the investigations and interventions necessary as soon as SBS is suspected. The Oulu University Hospital protocol for suspected child abuse is described. Authors also give an overview of the SBS path in Finland from the police and prosecution's point of view.


Asunto(s)
Maltrato a los Niños , Traumatismos Craneocerebrales , Síndrome del Bebé Sacudido , Lactante , Niño , Humanos , Finlandia/epidemiología , Maltrato a los Niños/diagnóstico , Síndrome del Bebé Sacudido/diagnóstico , Síndrome del Bebé Sacudido/epidemiología , Traumatismos Craneocerebrales/epidemiología
4.
Childs Nerv Syst ; 38(10): 1929-1936, 2022 10.
Artículo en Inglés | MEDLINE | ID: mdl-35732900

RESUMEN

PURPOSE: The aim of this study was to investigate the presence of depressive symptoms and self-esteem, and their association with facial asymmetry in adults who were operated on in early childhood due to metopic and sagittal craniosynostosis. METHODS: The study population consisted of 49 non-syndromic patients of whom 41 had premature fusion of the sagittal and 8 of metopic suture. There were 64 controls from the Finnish National Register. Self-esteem, depressive symptoms, and subjective satisfaction with one's appearance were evaluated by using the Rosenberg self-esteem questionnaire (RSE), the short form of Beck Depression Inventory (R-BDI), and a purpose-designed questionnaire on satisfaction with facial and overall appearance. Aesthetic evaluation was done from standard photographs using panels. The facial symmetry was calculated by using 3D photogrammetric methods. RESULTS: Patients did not have a lower self-esteem or experience significantly more moderate or severe depressive symptoms. However, 20% of the patients and 6% of the controls (p = 0.041) experienced mild depressive symptoms. There was no difference between self-assessed evaluation of appearance between the groups. Only weak correlation was found between facial asymmetry and RSE or R-BDI results (cc = 0.27-0.42, p < 0.05). The self-assessed evaluation of facial and overall appearance correlated strongly with the R-BDI results. CONCLUSION: Non-syndromic craniosynostosis patients are as satisfied with their appearance in adulthood as the control group and do not experience a lower self-esteem or more depressive symptoms. Facial asymmetry does not correlate with low self-esteem or clinically significant depressive symptoms in adulthood. Subjective evaluation of one's appearance correlated with depressive symptoms. Age and gender do not influence the former results. Overall, patients are satisfied with their appearance.


Asunto(s)
Craneosinostosis , Depresión , Adulto , Preescolar , Craneosinostosis/complicaciones , Craneosinostosis/cirugía , Depresión/etiología , Estética , Asimetría Facial , Humanos , Autoimagen
5.
Childs Nerv Syst ; 38(9): 1763-1772, 2022 09.
Artículo en Inglés | MEDLINE | ID: mdl-35739289

RESUMEN

PURPOSE: Decompressive craniectomy (DC) is an effective treatment of intracranial hypertension. Correspondingly, the procedure is increasingly utilised worldwide. The number of patients rendered vegetative following surgery has been a concern-a matter especially important in children, due to long anticipated lifetime. Here, we report the long-term outcomes of all paediatric DC patients from an 11-year period in a tertiary-level centre that geographically serves half of Finland. METHODS: We identified all patients younger than 18 years who underwent DC in the Oulu University Hospital between the years 2009 and 2019. Outcomes and clinicoradiological variables were extracted from the patient records. RESULTS: Mean yearly prevalence of brain injury requiring DC was 1.34/100 000 children-twenty-four patients underwent DC during the study period and 21 (88%) survived. The median age of the patients was 16.0 years, and the median preoperative GCS was 5.0 (IQR 5.0). Fifteen patients (63%) had made a good recovery (Extended Glasgow Outcome Scale ≥ 7). Of the surviving patients, two (9.5%) had not returned to school. After traumatic brain injury (n = 20), the Rotterdam CT score (mean 3.0, range 1 to 5) was not associated with mortality, poor recovery or inability to continue school (p = 0.13, p = 0.41, p = 0.43, respectively). Absent basal cisterns were associated with mortality (p = 0.005), but not with poor recovery if the patient survived DC (p = 0.81). Hydrocephalus was associated with poor recovery and inability to continue school (p = 0.01 and p = 0.03, respectively). CONCLUSION: Most of our patients made a favourable recovery and were able to continue school. No late mortality was observed. Thus, even in clinically and radiologically severely brain-injured children, decompressive craniectomy appears to yield favourable outcomes.


Asunto(s)
Lesiones Traumáticas del Encéfalo , Craniectomía Descompresiva , Hipertensión Intracraneal , Adolescente , Lesiones Traumáticas del Encéfalo/diagnóstico por imagen , Lesiones Traumáticas del Encéfalo/cirugía , Niño , Craniectomía Descompresiva/métodos , Finlandia/epidemiología , Escala de Consecuencias de Glasgow , Humanos , Hipertensión Intracraneal/cirugía , Estudios Retrospectivos , Resultado del Tratamiento
6.
Childs Nerv Syst ; 38(4): 781-788, 2022 04.
Artículo en Inglés | MEDLINE | ID: mdl-34940889

RESUMEN

PURPOSE: The aim of this study was to investigate the craniofacial and aesthetic characteristics of adult metopic and sagittal craniosynostosis patients operated on in early childhood compared to controls. The goal was to find objective measurements that would correlate with the patient's subjective self-evaluation of their own cosmetic appearance. METHODS: The study population consisted of 49 patients from whom 41 had premature fusion of the sagittal and in 8 of metopic suture. There were 65 age and gender matching controls from The Finish National Register. The 3D photogrammetric models were created from all patients and controls. The images were analysed using Rapidform 2006. Facial landmarks were set by the standard Farkas points. Facial symmetry parameters were calculated by using the landmarks and the mirror shell of the face. Aesthetic evaluation was done from standard photographs using panels. Subjective satisfaction with one's own appearance was evaluated using questionnaires. RESULTS: Patients had the greatest asymmetry in the forehead area when compared to controls (symmetry percentage 59% versus 66%, p = 0.013). In the control group, the gap between the eyes was smaller than in the case group, resulting in an absolute 2 mm difference (p = 0.003). The area of the chin and the landmarks were more located on the left side in the patient group, resulting in up to a 1.1 mm difference between the groups (p = 0.003). Only a weak association was found between craniofacial symmetry and appearance evaluations. CONCLUSION: Patients operated on because of sagittal and metopic synostoses were found to have facial asymmetry at long follow-up. However, the differences were < 3 mm and not clinically important. The long-term aesthetical outcome of the surgery performed because of sagittal or metopic craniosynostosis based on the 3D image evaluation was good.


Asunto(s)
Craneosinostosis , Satisfacción Personal , Adulto , Estudios de Casos y Controles , Preescolar , Craneosinostosis/diagnóstico por imagen , Craneosinostosis/cirugía , Humanos , Lactante , Satisfacción del Paciente , Fotogrametría
7.
Childs Nerv Syst ; 37(10): 3127-3136, 2021 10.
Artículo en Inglés | MEDLINE | ID: mdl-34032915

RESUMEN

Posterior cranial vault distraction is an effective technique when a significant increase in the intracranial volume is required in patients with craniosynostoses. This technique has been proven to be safe and time saving and usually is associated with low perioperative morbidity as well as low intraoperative bleeding. Herein a technique is presented starting from the preoperative planning, describing the surgical steps of the operation and the postoperative distraction protocol used by the authors. The authors present important tips and tricks aiming to minimise complications and undesired events.


Asunto(s)
Craneosinostosis , Osteogénesis por Distracción , Craneosinostosis/cirugía , Humanos , Lactante , Cráneo
8.
Childs Nerv Syst ; 37(8): 2707-2712, 2021 08.
Artículo en Inglés | MEDLINE | ID: mdl-33481101

RESUMEN

PURPOSE: The purpose of this study is to report a new mini-invasive technique to remove an intracranial bullet in a child by using O-arm for intraoperative neuronavigation. CASE REPORT: A 14-year-old refugee boy had suffered a shooting injury 4 years earlier. O-arm imaging-assisted neuronavigation during craniotomy was performed in order to remove a bullet from the intracranial space in a paediatric patient. CONCLUSION: Navigation using O-arm is a feasible method in removing a foreign material in a child and gave an accurate location of the bullet in the adopted surgical operation position without significant imaging artefacts.


Asunto(s)
Imagenología Tridimensional , Cirugía Asistida por Computador , Adolescente , Niño , Craneotomía , Humanos , Masculino , Neuronavegación , Tomografía Computarizada por Rayos X
9.
Acta Neurochir (Wien) ; 163(7): 2005-2014, 2021 07.
Artículo en Inglés | MEDLINE | ID: mdl-33977335

RESUMEN

BACKGROUND: The purpose of our study was to research the parameters of magnetic resonance imaging (MRI) that would predict the outcome of surgery in patients with Chiari 1 malformation (CM1) and to evaluate changes in MRI parameters after surgery. METHODS: Fifty-one patients (19 children, 13 adolescents, and 19 adults) operated on due to CM1 in Oulu University Hospital between 2004 and 2018 were evaluated. Seventeen parameters were measured from the preoperative MRI and 11 from the postoperative MRI. The correlations between the MRI parameters and the clinical variables before and after surgery were analyzed. RESULTS: The majority (88.2%) of the patients had favorable surgical outcomes. Postoperatively, subjective symptoms improved in 88.6% of the patients and syringomyelia in 81.8%. The location of the cerebellar tonsils, when measured in relation to the C2 synchondrosis or the end plate, postoperatively moved cranially in 51.0% (n = 26), did not change in 27.4% (n = 14), and moved caudally in 21.6% (n = 11) of the patients. However, neither the location of the tonsils nor any other parameters measured from pre- or postoperative MRI correlated with the patients' symptoms or surgical outcomes. CONCLUSIONS: No specific parameters on preoperative MRI evaluation were predictive of the outcome of surgery, emphasizing clinical examination in surgical decision-making. Furthermore, the postoperative MRI parameters did not correlate with the surgical outcomes. Thus, routine postoperative imaging is suggested only for patients with preoperatively diagnosed syringomyelia or worsening of symptoms.


Asunto(s)
Malformación de Arnold-Chiari , Adolescente , Adulto , Malformación de Arnold-Chiari/diagnóstico por imagen , Malformación de Arnold-Chiari/cirugía , Niño , Descompresión Quirúrgica , Hospitales Universitarios , Humanos , Imagen por Resonancia Magnética , Periodo Posoperatorio , Siringomielia/diagnóstico por imagen , Siringomielia/cirugía , Resultado del Tratamiento
10.
Acta Neurochir (Wien) ; 162(5): 1067-1076, 2020 05.
Artículo en Inglés | MEDLINE | ID: mdl-32103343

RESUMEN

BACKGROUND: Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is used in advanced Parkinson's disease (PD) for reducing motor fluctuations and the side effects of antiparkinsonian medication (APM). The development of neuroimaging has enabled the direct targeting of the STN. The aim of this study is to evaluate the outcome in patients with PD using STN DBS when changing from atlas-based indirect targeting method (iTM) to direct MRI-based targeting (dTM) assuming dTM is superior. METHODS: Twenty-five consecutive PD patients underwent dTM STN DBS surgery from 2014 to 2017 with follow-up for 1 year. The neuroimaging, surgical method, outcome in Unified Parkinson's Disease Rating Scale (UPDRS) scores, and reduction of APM are described and compared with the results of an earlier iTM STN DBS study. RESULTS: Twelve months after a dTM STN DBS, significant improvement (p < 0.001) was seen in six out of seven parameters of UPDRS when patients had medication (medON) and stimulation (stimON). The activities of daily living (UPDRSII) and motor scores (UPDRSIII) improved by 41% and 62%, respectively. Dyskinesias and fluctuations were both reduced by 81%. In dTM STN DBS group, the levodopa equivalent dose (LED) and the total daily levodopa equivalent dose (LEDD) were significantly decreased by 62% and 55%, respectively, compared with the baseline (p < 0.001). Five patients (20%) were without levodopa medication 12 months after the operation. CONCLUSIONS: The development of surgical technique based on advanced neuroimaging has improved the outcome of PD STN DBS.


Asunto(s)
Estimulación Encefálica Profunda/métodos , Enfermedad de Parkinson/terapia , Núcleo Subtalámico/cirugía , Actividades Cotidianas , Anciano , Antiparkinsonianos/uso terapéutico , Terapia Combinada , Femenino , Humanos , Levodopa/uso terapéutico , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Enfermedad de Parkinson/diagnóstico por imagen , Enfermedad de Parkinson/tratamiento farmacológico , Núcleo Subtalámico/diagnóstico por imagen , Resultado del Tratamiento
11.
Childs Nerv Syst ; 35(5): 851-856, 2019 05.
Artículo en Inglés | MEDLINE | ID: mdl-30847620

RESUMEN

BACKGROUND: Distraction techniques are effective methods for the treatment of craniosynostoses when a significant gain of an intracranial volume is required. However, this technique raises some challenges at different stages of the treatment. While installing the distractors in patients with thin calvarial bone, there is a risk of dural damage from the titanium screws. The need for wide exposure of the devices and the screws during removal causes soft tissue damage and bleeding. OBJECTIVE: This study aimed to evaluate sonic pin use in the distraction procedures. METHODS: Resorbable sonic pins were used in 11 consecutive posterior cranial vault distraction procedures to attach distraction devices to the calvarial bone. RESULTS: This method allowed for a less traumatic and faster removal of the devices without the risk of leaving foreign bodies in the wound. In three out of 11 cases on follow-up, displacement of proximal distractor footplate and partial relapse of distraction were detected. Though there was a smaller volume increase in these patients, all of them benefited clinically from the PCVD and did not require reoperations. CONCLUSIONS: This method allows a strong and stable attachment of the distractor devices to the cranial vault bones with a reduced risk of dural tears due to the screws. It also allows for easier and less traumatic device removal.


Asunto(s)
Implantes Absorbibles , Clavos Ortopédicos , Craneosinostosis/diagnóstico por imagen , Craneosinostosis/cirugía , Imagenología Tridimensional/métodos , Osteogénesis por Distracción/métodos , Preescolar , Femenino , Humanos , Lactante , Fijadores Internos , Masculino , Osteogénesis por Distracción/instrumentación , Tomografía Computarizada por Rayos X/métodos
12.
Acta Neurochir (Wien) ; 161(3): 473-481, 2019 03.
Artículo en Inglés | MEDLINE | ID: mdl-30644012

RESUMEN

BACKGROUND: Bone flap resorption (BFR) is the most prevalent complication resulting in autologous cranioplasty failure, but no consensus on the definition of BFR or between the radiological signs and relevance of BFR has been established. We set out to develop an easy-to-use scoring system intended to standardize the interpretation of radiological BFR findings. METHODS: All 45 autologous cranioplasty patients operated on at Oulu University Hospital from 2004 to 2014 were identified, and the bone flap status of all the available patients was evaluated using the new scoring system. Derived from previous literature, a three-variable score for the detection of BFR changes is proposed. The variables "Extent" (estimated remaining bone volume), "Severity" (possible perforations and their measured diameter), and "Focus" (the number of BFR foci within the flap) are scored from 0 to 3 individually. Using the sum of these scores, a score of 0-9 is assigned to describe the degree of BFR. Additionally, independent neurosurgeons assessed the presence and relevance of BFR from the same data set. These assessments were compared to the BFR scores in order to find a score limit for relevant BFR. RESULTS: BFR was considered relevant by the neurosurgeons in 11 (26.8%) cases. The agreement on the relevance of BFR demonstrated substantial strength (κ 0.64, 95%CI 0.36 to 0.91). The minimum resorption score in cases of relevant BFR was 5. Thus, BFR with a resorption score ≥ 5 was defined relevant (grades II and III). With this definition, grade II or III BFR was found in 15 (36.6%) of our patients. No risk factors were found to predict relevant BFR. CONCLUSIONS: The score was proven to be easy to use and we recommend that only cases with grades II and III BFR undergo neurosurgical consultation. However, general applicability can only be claimed after validation in independent cohorts.


Asunto(s)
Resorción Ósea/diagnóstico por imagen , Craniectomía Descompresiva/métodos , Complicaciones Posoperatorias/diagnóstico por imagen , Colgajos Quirúrgicos/cirugía , Tomografía Computarizada por Rayos X/métodos , Adulto , Resorción Ósea/clasificación , Craniectomía Descompresiva/efectos adversos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/clasificación , Cráneo/diagnóstico por imagen , Cráneo/cirugía , Colgajos Quirúrgicos/patología , Tomografía Computarizada por Rayos X/normas
13.
Carcinogenesis ; 38(8): 812-820, 2017 08 01.
Artículo en Inglés | MEDLINE | ID: mdl-28854563

RESUMEN

Central nervous system (CNS) relapse is a devastating complication that occurs in about 5% of diffuse large B-cell lymphoma (DLBCL) patients. Currently, there are no predictive biological markers. We wanted to study potential biomarkers of CNS tropism that play a role in adhesion, migration and/or in the regulation of inflammatory responses. The expression levels of ITGA10, CD44, PTEN, cadherin-11, CDH12, N-cadherin, P-cadherin, lactoferrin and E-cadherin were studied with IHC and IEM. GEP was performed to see whether found expressional changes are regulated at DNA/RNA level. IHC included 96 samples of primary CNS lymphoma (PCNSL), secondary CNS lymphoma (sCNSL) and systemic DLBCL (sDLBCL). IEM included two PCNSL, one sCNSL, one sDLBCL and one reactive lymph node samples. GEP was performed on two DLBCL samples, one with and one without CNS relapse. CNS disease was associated with enhanced expression of cytoplasmic and membranous ITGA10 and nuclear PTEN (P < 0.0005, P = 0.002, P = 0.024, respectively). sCNSL presented decreased membranous CD44 and nuclear and cytoplasmic cadherin-11 expressions (P = 0.001, P = 0.006, P = 0.048, respectively). In PCNSL lactoferrin expression was upregulated (P < 0.0005). IEM results were mainly supportive of the IHC results. In GEP CD44, cadherin-11, lactoferrin and E-cadherin were under-expressed in CNS disease. Our results are in line with previous studies, where gene expressions in extracellular matrix and adhesion-related pathways are altered in CNS lymphoma. This study gives new information on the DLBCL CNS tropism. If further verified, these markers might become useful in predicting CNS relapses.


Asunto(s)
Cadherinas/genética , Enfermedades del Sistema Nervioso Central/genética , Receptores de Hialuranos/genética , Cadenas alfa de Integrinas/genética , Lactoferrina/genética , Linfoma de Células B Grandes Difuso/genética , Fosfohidrolasa PTEN/genética , Adulto , Anciano , Anciano de 80 o más Años , Biomarcadores de Tumor/genética , Cadherinas/biosíntesis , Sistema Nervioso Central/patología , Enfermedades del Sistema Nervioso Central/etiología , Enfermedades del Sistema Nervioso Central/patología , Femenino , Regulación Neoplásica de la Expresión Génica , Humanos , Receptores de Hialuranos/biosíntesis , Cadenas alfa de Integrinas/biosíntesis , Lactoferrina/biosíntesis , Ganglios Linfáticos/metabolismo , Ganglios Linfáticos/patología , Linfoma de Células B Grandes Difuso/complicaciones , Linfoma de Células B Grandes Difuso/patología , Masculino , Persona de Mediana Edad , Fosfohidrolasa PTEN/biosíntesis
14.
Neuroradiology ; 59(12): 1265-1273, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-28942520

RESUMEN

PURPOSE: Pineal cysts are common incidental findings in children undergoing magnetic resonance imaging (MRI). Several studies have suggested MRI follow-up if the cyst is larger than 10 mm. However, cysts do not usually change during follow-up. Prevalence, growth, and structure of the pineal cysts were analyzed to decide if follow-up MRI is necessary. METHODS: A retrospective review between 2010 and 2015 was performed using 3851 MRI examinations of children aged 0-16 years to detect pineal cysts having a maximum diameter ≥ 10 mm. Eighty-one children with pineal cysts were identified and 79 of them had been controlled by MRI. Cysts were analyzed for the size, growth, and structure. RESULTS: A total of 1.8% of the children had a pineal cyst with a diameter ≥ 10 mm. Cysts were present in 48 girls (59.3%) and 33 boys (40.7%). Most pineal cysts (70/79) did not significantly grow during the follow-up (median 10 months, range 3-145 months). A total of 11.4% (9/79) of the cysts grew with the biggest change measured from the outer cyst wall sagittal anteroposterior dimension (mean 3.4 mm ± 1.7 mm). Only one cyst grew more than 5 mm. We found no factors correlating with the cyst growth among 9 cysts that grew > 2 mm. CONCLUSIONS: A majority of pineal cysts remained unchanged during the MRI follow-up. Results of this study suggest that routine MRI follow-up of pineal cysts is not necessary in the absence of unusual radiological characteristics or related clinical symptoms.


Asunto(s)
Quistes del Sistema Nervioso Central/diagnóstico por imagen , Imagen por Resonancia Magnética/métodos , Glándula Pineal/diagnóstico por imagen , Adolescente , Quistes del Sistema Nervioso Central/patología , Niño , Preescolar , Femenino , Humanos , Hallazgos Incidentales , Lactante , Recién Nacido , Masculino , Glándula Pineal/patología , Estudios Retrospectivos
15.
Eur J Haematol ; 96(5): 492-501, 2016 May.
Artículo en Inglés | MEDLINE | ID: mdl-26153511

RESUMEN

Central nervous system (CNS) relapse occurs in around 5% of diffuse large B-cell lymphoma (DLBCL) cases. No biomarkers to identify high-risk patients have been discovered. We evaluated the expression of lymphocyte-guiding chemokine receptors in systemic and CNS lymphomas. Immunohistochemical staining for CXCR4, CXCR5, CCR7, CXCL12, and CXCL13 was performed on 89 tissue samples, including cases of primary central nervous system lymphoma (PCNSL), secondary CNS lymphoma (sCNSL), and systemic DLBCL. Also, 10 reactive lymph node samples were included. Immunoelectron microscopy was performed on two PCNSLs, one sCNSL, one systemic DLBCL, and one reactive lymph node samples, and staining was performed for CXCR4, CXCR5, CXCL12, and CXCL13. Chi-square test was used to determine correlations between clinical parameters, diagnostic groups, and chemokine receptor expression. Strong nuclear CXCR4 positivity correlated with systemic DLBCL, whereas strong cytoplasmic CXCR5 positivity correlated with CNS involvement (P = 0.003 and P = 0.039). Immunoelectron microscopy revealed a nuclear CXCR4 staining in reactive lymph node, compared with cytoplasmic and membranous localization seen in CNS lymphomas. We found that CNS lymphoma presented a chemokine receptor profile different from systemic disease. Our findings give new information on the CNS tropism of DLBCL and, if confirmed, may contribute to more effective targeting of CNS prophylaxis among patients with DLBCL.


Asunto(s)
Neoplasias del Sistema Nervioso Central/metabolismo , Neoplasias del Sistema Nervioso Central/secundario , Linfoma/metabolismo , Linfoma/patología , Receptores de Quimiocina/metabolismo , Adulto , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Biomarcadores , Estudios de Casos y Controles , Neoplasias del Sistema Nervioso Central/tratamiento farmacológico , Células Endoteliales/metabolismo , Femenino , Humanos , Inmunohistoquímica , Ganglios Linfáticos/metabolismo , Ganglios Linfáticos/patología , Linfoma de Células B Grandes Difuso/metabolismo , Linfoma de Células B Grandes Difuso/patología , Masculino , Persona de Mediana Edad , Premedicación , Estudios Retrospectivos
16.
Duodecim ; 132(11): 1061-8, 2016.
Artículo en Fi | MEDLINE | ID: mdl-27400592

RESUMEN

BACKGROUND: Although the majority of trampoline injuries in children are minor, severe injuries occur as well. METHODS: We have analyzed the risk factors, treatment and outcome of severe trampoline injuries treated in the Oulu University Hospital in children and the young between April and November 2105. RESULTS: There was a total of eight severe injuries. Five injuries involved a danger of death. Almost all severe trampoline injuries resulted from an unsuccessful trick. A safety net was in use in half of the cases. CONCLUSIONS: All cervical spine injuries would have been avoided provided that the children would have refrained from doing a somersault on the trampoline.


Asunto(s)
Traumatismos en Atletas/etiología , Traumatismos en Atletas/terapia , Juego e Implementos de Juego , Adolescente , Traumatismos en Atletas/epidemiología , Niño , Femenino , Finlandia/epidemiología , Humanos , Masculino , Traumatismos del Cuello/epidemiología , Traumatismos del Cuello/etiología , Traumatismos del Cuello/terapia , Factores de Riesgo
17.
Childs Nerv Syst ; 31(7): 1121-8, 2015 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-25715840

RESUMEN

INTRODUCTION: Premature ossification of coronal and metopic sutures is treated by fronto-orbital remodeling. Such operations require stable fixation of the reshaped cranial bones. Currently, biodegradable plating systems are used to provide sufficient stability over the time that takes for the osteotomies to ossify. Plates that are placed traditionally on the outer surface of the cranium are often palpable and even visible through the thin overlying skin, compromising the cosmetic results of these operations. Improved aesthetics could be achieved by placing the plates endocranially. PURPOSE: This study aimed to evaluate endocranial resorbable plate fixation and its clinical and radiographic results in frontal remodeling cranioplasty for plagiocephaly and trigonocephaly patients with follow-up sufficiently long for the plates to have been completely resorbed. METHODS: A poly(lactide-co-glycolide) (PLGA) resorbable plating system was used on the inner aspect of frontal bone in 27 patients treated for coronal and metopic craniosynostoses. The outcome was evaluated at follow-up visits. The mean follow-up was 79.2 months. RESULTS: Three patients had complications that required reoperations. None of these complications were related to the endocranial location of the plates. There were no problems with ossification of the osteotomy sites. All but one patient's outcome was judged as good or excellent. CONCLUSION: Placement of resorbable fixation on the endocranial surface of the calvarial bones is safe, stable, and results in satisfactory aesthetics without interfering with the ossification of the cranial bones.


Asunto(s)
Implantes Absorbibles , Craneosinostosis/cirugía , Plagiocefalia/cirugía , Procedimientos de Cirugía Plástica/métodos , Placas Óseas , Preescolar , Craneotomía/métodos , Femenino , Hueso Frontal/cirugía , Humanos , Lactante , Masculino , Estudios Retrospectivos , Resultado del Tratamiento
18.
World Neurosurg ; 2024 Jul 26.
Artículo en Inglés | MEDLINE | ID: mdl-39069131

RESUMEN

BACKGROUND: Neurosurgeons may resort to caffeine, alcohol, and various drugs to maintain peak performance as they grapple with work demands and escalated stress. The prevalence of this controversial strategy remains largely unexplored. METHODS: An anonymous survey of 23 questions formulated by our research group was distributed through personal contacts and neurosurgical societies. Inquiries revolved around the use of medications and other substances for job-related reasons. Data were analyzed via regression and descriptive statistics in python. RESULTS: In total, 215 neurosurgeons (43 residents) were included, with 213 disclosing their gender (94 females). Out of all, 9.3% were <30, 38.1% were 30-39, 44.6% were 40-59 and 7.9% were >60 years old. Most (70.7%) practiced in Europe, 18.6% in Asia, 6.5% in North and South America and the rest in Africa or Australia. While 132 participants stated they consume caffeine to manage challenging schedules, drugs for cognitive and mood enhancement were utilized by 18 and 35 respectively. Alcohol was employed for stress relief by 28 with 4 reporting as heavy drinkers. Drugs posed a solution to sleep disorders for 82, and helped 8 others in strengthening their hand dexterity. Notably, 12 of those claiming drug use, initiated it in medical school. Exercise, self-care activities and relational support were the main alternatives sought. Ultimately, most responders recommended extending mental health assistance and raising awareness about drug use. CONCLUSIONS: Reflecting on our results on job-associated drug use by neurosurgeons, we propose the judicious use of pharmacological or non- adjuncts, alongside the prioritization of neurosurgeons' well-being.

19.
World Neurosurg ; 185: e523-e531, 2024 05.
Artículo en Inglés | MEDLINE | ID: mdl-38382757

RESUMEN

BACKGROUND: Neurosurgery, an intricate and dynamic surgical specialty, faces challenges in attracting medical graduates. Despite its potential appeal, a decreasing trend in medical students opting for surgical specialties, including neurosurgery, is noted. This study aims to assess European medical students' perceptions of neurosurgery, focusing on South-East Europe, and address concerns about the declining interest in this field. METHODS: A comprehensive digital survey, comprising 33 questions, was distributed to 1115 medical students across 17 European countries. The survey, conducted over 9 months, gathered responses through European neurosurgical societies, the European Association of Neurosurgical Societies (EANS), and university channels. Statistical analysis utilized IBM Statistical Package for the Social Sciences, presenting data through counts, proportions, and χ2 tests. RESULTS: The study reveals that, over the survey period, 834 medical students completed the questionnaire, with a predominant representation from South-East Europe. While 43.2% of participants were considering a surgical career, neurosurgery emerged as the most preferred specialty (26.37%). Despite this interest, 80.2% reported insufficient knowledge about pursuing a neurosurgical career, with limited exposure during medical education. Concerns about work-life balance, heavy workload, and hierarchical structures were prominent among respondents. CONCLUSIONS: The findings underscore the need for targeted interventions to address concerns influencing medical students' decisions regarding neurosurgery. Improving neurosurgical education, dispelling misconceptions, and creating a supportive work environment are crucial steps to attract and retain diverse talented individuals in neurosurgery. These efforts will be vital in narrowing the gap between the demand for neurosurgeons and the number of medical graduates entering the field, ensuring a sustainable future for this essential surgical specialty.


Asunto(s)
Selección de Profesión , Neurocirugia , Estudiantes de Medicina , Estudiantes de Medicina/psicología , Estudiantes de Medicina/estadística & datos numéricos , Humanos , Neurocirugia/educación , Masculino , Femenino , Encuestas y Cuestionarios , Europa (Continente) , Adulto , Grecia , Adulto Joven , Serbia , Turquía , Actitud del Personal de Salud
20.
Childs Nerv Syst ; 29(8): 1359-61, 2013 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-23666432

RESUMEN

INTRODUCTION: We describe a new technique in distraction cranioplasty procedure to facilitate the placement of cranial distractors in a correct position. CONCLUSION: Avoiding conflict of the vectors when placing several distractors allows later attainment of the planned amount of distraction.


Asunto(s)
Craneosinostosis/cirugía , Osteogénesis por Distracción/instrumentación , Cráneo/cirugía , Humanos
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