RESUMEN
Neuroendocrine tumors tend to grow slowly and are notoriously difficult to localize, at least in the early stages. Metastases are in most cases already present at the time of diagnosis. Somatostatin receptor scintigraphy improves detection of small and occult NET tumors. Intraoperative probe counting with a hand-held gamma probe can identify tumors even when they are small and impalpable, but receptor positive. This advanced operative approach may improve the survival of these patients.
Asunto(s)
Diagnóstico por Imagen/métodos , Tumores Neuroendocrinos/cirugía , Radiografía Intervencional/métodos , Biomarcadores de Tumor/análisis , Humanos , Radioisótopos de Indio , Imagen por Resonancia Magnética/métodos , Estadificación de Neoplasias/métodos , Tumores Neuroendocrinos/diagnóstico por imagen , Tumores Neuroendocrinos/tratamiento farmacológico , Tumores Neuroendocrinos/secundario , Tomografía de Emisión de Positrones/métodos , Cuidados Posoperatorios , Radiofármacos , Receptores de Somatostatina/análisis , Sensibilidad y Especificidad , Somatostatina/análogos & derivados , Tomografía Computarizada de Emisión de Fotón Único/métodos , UltrasonografíaRESUMEN
Many radiopharmaceuticals have been successfully used in nuclear medicine to detect neuroendocrine tumors, and many of them are based on a specific mechanism of uptake, while others are non-specific probes. This "review" focuses on the clinical applications of metaiodobenzylguanidine, (111)In-pentreotide and positron emission tomography (PET) tracers. New avances in diagnostic imaging will be discussed. Molecular imaging serves these diagnostic functions and provides powerful means for non-invasively detecting disease.
Asunto(s)
Tumores Neuroendocrinos/diagnóstico por imagen , Tomografía de Emisión de Positrones/métodos , Radiofármacos , Somatostatina/análogos & derivados , 3-Yodobencilguanidina/farmacocinética , Neoplasias de las Glándulas Suprarrenales/diagnóstico por imagen , Biomarcadores de Tumor/análisis , Carcinoma Medular/diagnóstico por imagen , Neoplasias Gastrointestinales/diagnóstico por imagen , Humanos , Radioisótopos de Yodo , Tumores Neuroendocrinos/química , Feocromocitoma/diagnóstico por imagen , Radiofármacos/farmacocinética , Receptores de Somatostatina/análisis , Sensibilidad y Especificidad , Somatostatina/farmacocinética , Somatostatina/fisiología , Neoplasias de la Tiroides/diagnóstico por imagen , Tomografía Computarizada de Emisión de Fotón Único/métodosRESUMEN
Bone is one of the most common metastasis sites from solid tumors. Bone pain due to metastatic neoplastic growth is due to tumor infiltration and expansion of bone membranes. Treatment of acute and chronic pain represents one of the greatest problems in clinical oncology, requiring a multidisciplinary approach. This review focuses on the effectiveness of conventional diagnostic radiology and nuclear medicine for the detection, management and treatment of pain from bone metastasis.