RESUMEN
A low molecular weight fraction of bovine aortic extract inhibited corneal vascularization and edema in rabbits when administered either subconjunctivally or topically as long as 48 hours after injury. The extract also appeared to enhance the regression of newly formed corneal vessels. Topical administration for as long as two months had no deleterious ocular side effects. Tissue culture experiments showed that analagous fractions prepared from bovine vitreous inhibit endothelial cell growth. The major growth inhibitor of corneal neovascularization was not the Kunitz bovine protease inhibitor.
Asunto(s)
Aorta/fisiología , Córnea/irrigación sanguínea , Neovascularización Patológica/efectos de los fármacos , Extractos de Tejidos/farmacología , Animales , Aprotinina/farmacología , Quemaduras Químicas/etiología , Bovinos , Lesiones de la Cornea , Edema/prevención & control , Endotelio/citología , Quemaduras Oculares/inducido químicamente , Masculino , Peso Molecular , Inhibidores de Proteasas/farmacología , Conejos , Nitrato de Plata , Extractos de Tejidos/administración & dosificación , Extractos de Tejidos/uso terapéuticoRESUMEN
Neural crest and nonneural crest tumors occur frequently in neurofibromatosis (NF). We report one case of NF and recurrent malignant fibrous histiocytoma, a tumor that is uncommon in childhood, and another case of the concomitant occurrence of NF, hemophilia B, and a paratesticular rhabdomyosarcoma.