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1.

Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival.

Zhou, Xiaolan; Wang, Jin Lin; Lu, John; Song, Yanping; Kwak, Keith S; Jiao, Qingsheng; Rosenfeld, Robert; Chen, Qing; Boone, Thomas; Simonet, W Scott; Lacey, David L; Goldberg, Alfred L; Han, H Q.

Cell ; 142(4): 531-43, 2010 Aug 20.

Artículo en Inglés | MEDLINE | ID: mdl-20723755

2.

Inhibition of WISE preserves renal allograft function.

Qian, Xueming; Yuan, Xiaodong; Vonderfecht, Steven; Ge, Xupeng; Lee, Jae; Jurisch, Anke; Zhang, Li; You, Andrew; Fitzpatrick, Vincent D; Williams, Alexia; Valente, Eliane G; Pretorius, Jim; Stevens, Jennitte L; Tipton, Barbara; Winters, Aaron G; Graham, Kevin; Harriss, Lindsey; Baker, Daniel M; Damore, Michael; Salimi-Moosavi, Hossein; Gao, Yongming; Elkhal, Abdallah; Paszty, Chris; Simonet, W Scott; Richards, William G; Tullius, Stefan G.

J Am Soc Nephrol ; 24(1): 66-76, 2013 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-23184054

3.

Sclerostin Antibody Reverses Bone Loss by Increasing Bone Formation and Decreasing Bone Resorption in a Rat Model of Male Osteoporosis.

Li, Xiaodong; Ominsky, Michael S; Villasenor, Kelly S; Niu, Qing-Tian; Asuncion, Frank J; Xia, Xuechun; Grisanti, Mario; Wronski, Thomas J; Simonet, W Scott; Ke, Hua Zhu.

Endocrinology ; 159(1): 260-271, 2018 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-29069393

4.

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia.

Li, Ji; Sarosi, Ildiko; Cattley, Russell C; Pretorius, James; Asuncion, Frank; Grisanti, Mario; Morony, Sean; Adamu, Stephen; Geng, Zhaopo; Qiu, Wanrong; Kostenuik, Paul; Lacey, David L; Simonet, W Scott; Bolon, Brad; Qian, Xueming; Shalhoub, Victoria; Ominsky, Michael S; Zhu Ke, Hua; Li, Xiaodong; Richards, William G.

Bone ; 39(4): 754-66, 2006 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-16730481

5.

Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab.

Lacey, David L; Boyle, William J; Simonet, W Scott; Kostenuik, Paul J; Dougall, William C; Sullivan, John K; San Martin, Javier; Dansey, Roger.

Nat Rev Drug Discov ; 11(5): 401-19, 2012 May.

Artículo en Inglés | MEDLINE | ID: mdl-22543469

6.

Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury.

Li, Xiaodong; Grisanti, Mario; Fan, Wei; Asuncion, Frank J; Tan, Hong-Lin; Dwyer, Denise; Han, Chun-Ya; Yu, Longchuan; Lee, Jae; Lee, Edward; Barrero, Mauricio; Kurimoto, Pam; Niu, Qing-Tian; Geng, Zhaopo; Winters, Aaron; Horan, Tom; Steavenson, Shirley; Jacobsen, Frederick; Chen, Qing; Haldankar, Raj; Lavallee, Jennifer; Tipton, Barbara; Daris, Mark; Sheng, Jackie; Lu, Hsieng S; Daris, Kristi; Deshpande, Rohini; Valente, Eliane G; Salimi-Moosavi, Hossein; Kostenuik, Paul J; Li, Ji; Liu, Min; Li, Chaoyang; Lacey, David L; Simonet, W Scott; Ke, Hua Zhu; Babij, Philip; Stolina, Marina; Ominsky, Michael S; Richards, William G.

J Bone Miner Res ; 26(11): 2610-21, 2011 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-21773994

7.

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength.

Ominsky, Michael S; Vlasseros, Fay; Jolette, Jacquelin; Smith, Susan Y; Stouch, Brian; Doellgast, George; Gong, Jianhua; Gao, Yongming; Cao, Jin; Graham, Kevin; Tipton, Barbara; Cai, Jill; Deshpande, Rohini; Zhou, Lei; Hale, Michael D; Lightwood, Daniel J; Henry, Alistair J; Popplewell, Andrew G; Moore, Adrian R; Robinson, Martyn K; Lacey, David L; Simonet, W Scott; Paszty, Chris.

J Bone Miner Res ; 25(5): 948-59, 2010 May.

Artículo en Inglés | MEDLINE | ID: mdl-20200929

8.

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis.

Li, Xiaodong; Ominsky, Michael S; Warmington, Kelly S; Morony, Sean; Gong, Jianhua; Cao, Jin; Gao, Yongming; Shalhoub, Victoria; Tipton, Barbara; Haldankar, Raj; Chen, Qing; Winters, Aaron; Boone, Tom; Geng, Zhaopo; Niu, Qing-Tian; Ke, Hua Zhu; Kostenuik, Paul J; Simonet, W Scott; Lacey, David L; Paszty, Chris.

J Bone Miner Res ; 24(4): 578-88, 2009 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-19049336

9.

Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin.

Li, Xiaodong; Ominsky, Michael S; Stolina, Marina; Warmington, Kelly S; Geng, Zhaopo; Niu, Qing-Tian; Asuncion, Frank J; Tan, Hong-Lin; Grisanti, Mario; Dwyer, Denise; Adamu, Steven; Ke, Hua Zhu; Simonet, W Scott; Kostenuik, Paul J.

Bone ; 45(4): 669-76, 2009 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-19539794

10.

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.

Li, Xiaodong; Ominsky, Michael S; Niu, Qing-Tian; Sun, Ning; Daugherty, Betsy; D'Agostin, Diane; Kurahara, Carole; Gao, Yongming; Cao, Jin; Gong, Jianhua; Asuncion, Frank; Barrero, Mauricio; Warmington, Kelly; Dwyer, Denise; Stolina, Marina; Morony, Sean; Sarosi, Ildiko; Kostenuik, Paul J; Lacey, David L; Simonet, W Scott; Ke, Hua Zhu; Paszty, Chris.

J Bone Miner Res ; 23(6): 860-9, 2008 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-18269310

11.

Genetics of primary generalized osteoarthritis.

Simonet, W Scott.

Mol Genet Metab ; 77(1-2): 31-4, 2002.

Artículo en Inglés | MEDLINE | ID: mdl-12359127

12.

Osteoclast differentiation and activation.

Boyle, William J; Simonet, W Scott; Lacey, David L.

Nature ; 423(6937): 337-42, 2003 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-12748652

13.

The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction.

Bolon, Brad; Jing, Shuqian; Asuncion, Frank; Scully, Sheila; Pisegna, Marlese; Van, Gwyneth Y; Hu, Zheng; Yu, Yan Bin; Min, Hosung; Wild, Ken; Rosenfeld, Robert D; Tarpley, John; Carnahan, Josette; Duryea, Diane; Hill, Dave; Kaufman, Steve; Yan, Xiao-Qiang; Juan, Todd; Christensen, Kathy; McCabe, James; Simonet, W Scott.

Toxicol Pathol ; 32(3): 275-94, 2004.

Artículo en Inglés | MEDLINE | ID: mdl-15204970

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