1.
Dokl Biochem Biophys
; 466: 28-31, 2016.
Artículo
en Inglés
| MEDLINE
| ID: mdl-27025482
RESUMEN
The effect on ozone-induced oxidation on the self-assembly of fibrin in the presence of fibrin-stabilizing factor FXIIIa of soluble cross-linked fibrin oligomers was studied in a medium containing moderate urea concentrations. It is established that fibrin oligomers were formed by the protofibrils cross-linked through γ-γ dimers and the fibrils additionally cross-linked by through α-polymers. The oxidation promoted both the accumulation of greater amounts of γ-γ dimers and the formation of protofibrils, fibrils, and their dissociation products emerging with increasing urea concentrations, which have a high molecular weight. It is concluded that the oxidation enhances the axial interactions between D-regions of fibrin molecules.
Asunto(s)
Fibrina/química , Multimerización de Proteína , Factor XIII/química , Factor XIII/metabolismo , Fibrina/metabolismo , Humanos , Oxidación-Reducción , Unión Proteica , Urea/química
2.
Dokl Biochem Biophys
; 461: 139-41, 2015.
Artículo
en Inglés
| MEDLINE
| ID: mdl-25937234