RESUMEN
Ten early rheumatoid arthritis (RA) patients and 10 healthy volunteers were given 200 mg of ketoprofen daily for 8 days. Polymorphonuclear cell functional studies were performed just before and immediately after this treatment. In RA patients, increased chemotactic index and adherence returned to normal after this short-term treatment whilst reduced phagocytosis and bacterial function were not significantly modified by the drug. In healthy volunteers, no significant effect was shown. In addition, ketoprofen diminished the chemotactic activity induced by zymosan in RA patients and also in healthy volunteer plasma.
Asunto(s)
Artritis Reumatoide/inmunología , Cetoprofeno/farmacología , Neutrófilos/efectos de los fármacos , Fenilpropionatos/farmacología , Adulto , Artritis Reumatoide/sangre , Artritis Reumatoide/tratamiento farmacológico , Actividad Bactericida de la Sangre/efectos de los fármacos , Adhesión Celular/efectos de los fármacos , Quimiotaxis de Leucocito/efectos de los fármacos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neutrófilos/inmunología , Fagocitosis/efectos de los fármacosAsunto(s)
Enfermedad Hepática Inducida por Sustancias y Drogas/etiología , Epirrubicina/farmacocinética , Tamoxifeno/efectos adversos , Adenocarcinoma/tratamiento farmacológico , Adenocarcinoma/secundario , Neoplasias Óseas/tratamiento farmacológico , Neoplasias Óseas/secundario , Neoplasias de la Mama , Femenino , Humanos , Persona de Mediana EdadRESUMEN
Sera from 367 patients with rheumatoid arthritis (RA) and from 102 patients with other non-organ-specific (NOS) autoimmune diseases were examined for the presence of organ-specific (OS) autoantibodies. The incidence of these OS autoantibodies was not increased in patients with NOS autoimmune diseases with the exception of thyroglobulin antibodies, which were significantly more frequent in RA (P less than 0.001) and in Sjögren's syndrome (P less than 0.05) patients than in normal controls. Investigation of 169 patients with OS autoimmune diseases did not reveal an increased prevalence of NOS autoantibodies. In RA patients, OS autoantibodies correlated with NOS autoantibodies (P less than 0.04) and with HLA-DR3 antigen (P less than 0.01).