1.
J Org Chem
; 88(3): 1749-1761, 2023 Feb 03.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36649653
RESUMEN
A new method for directly synthesizing acylated and alkylated quinazoline derivatives by the epoxide ring-opening reaction in the presence of I2/DMSO with 2-aminobenzamide is described herein. The developed mild protocol is efficient and displays a wide variety of functional group tolerance and substrate-controlled high selectivity, and the application of a continuous flow technique allows for faster reaction time and higher yields. Moreover, the robustness of the method is applicable in gram-scale synthesis.