1.
Chemistry
; 19(17): 5476-86, 2013 Apr 22.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23447120
RESUMEN
The enantioselective total synthesis of (+)-ophiobolinâ A is described. This total synthesis features the construction of the spiro CDâ ring of (+)-ophiobolinâ A through a stereoselective intramolecular Hosomi-Sakurai cyclization reaction, the joining of the Aâ ring to the CDâ ring by using a reaction reported by Utimoto, and the construction of the ophiobolin eight-membered carbocyclic ring through ring-closing metathesis (RCM), which was performed for the first time in this study. This successful RCM reaction required the use of a substrate that contained either a benzyloxy or a methoxymethoxy group at the C5 position and either an isopropenyl group or its hydroxylated form at the C6 position.
Asunto(s)
Sesterterpenos/síntesis química , Ciclización , Estructura Molecular , Sesterterpenos/química , Estereoisomerismo
2.
Angew Chem Int Ed Engl
; 50(40): 9452-5, 2011 Sep 26.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21915975