[Maxillary sinus cancer review in 23 patients treated with postoperative radiotherapy]. / Revisión del cáncer de seno maxilar en 23 pacientes tratados con radioterapia postoperatoria.

OBJECTIVE: To describe the survival and outcome of maxillary sinus cancer in patients managed with surgery and post-operative radiotherapy during the last 10 years in our hospital. PATIENTS AND METHOD: Descriptive, retrospective, non-randomized study of 23 patients with cancer of the maxillary sinus managed at the Vigo University Hospital Complex, Spain, with radical surgery and post-operative radiotherapy, between 1995 and 2004. RESULTS: The 3-year actuarial survival was 47.8% and the adjusted actuarial survival was 60.8%. Permanent local tumour control was achieved in 60.8% of cases (14/23). Local tumour recurrence was the main cause of treatment failure (33.3%; 4/12). The most significant prognostic factors affecting local tumour control and survival were: clinical stage (P< .031), suprastructural location of the tumour (P< .001), and presence of positive resection margins (P< .001). CONCLUSIONS: Local recurrence was found to be very high and generally the main cause of death. New treatment protocols should be assessed.

Revisión del cáncer de seno maxilar en 23 pacientes tratados con radioterapia postoperatoria / Maxillary sinus cancer review in 23 patients treated with postoperative radiotherapy

Objetivo: Describir el comportamiento del cáncer del seno maxilar y la experiencia acumulada durante 10 años en el manejo de este tipo de neoplasia en nuestro hospital mediante el tratamiento con cirugía y radioterapia postoperatoria. Pacientes y método: El presente es un estudio descriptivo, retrospectivo y no aleatorizado, que se llevó a cabo en el Complejo Hospitalario Universitario de Vigo, con 23 pacientes con cáncer de seno maxilar que recibieron tratamiento con fines curativos entre los años 1995 y 2004. Todos fueron sometidos a cirugía radical y radioterapia postoperatoria. Resultados: La supervivencia actuarial a 3 años fue del 47,8 % y la corregida, del 60,8 %. El control local permanente se consiguió en 14/23 (60,8 %) pacientes. La causa principal de fracaso del tratamiento fue la recurrencia local 4/12 (33,3 %). Los factores pronósticos más significativos que afectaron al control local y la supervivencia fueron: el estadio clínico (p < 0,031), la localización del tumor en la supraestructura (p < 0,001) y los márgenes de sección quirúrgicos positivos (p < 0,001). Conclusiones: La recurrencia local es muy alta y generalmente la principal causa de muerte. Hay que explorar nuevos protocolos de tratamiento

Objective: To describe the survival and outcome of maxillary sinus cancer in patients managed with surgery and post-operative radiotherapy during the last 10 years in our hospital. Patients and method: Descriptive, retrospective, non-randomized study of 23 patients with cancer of the maxillary sinus managed at the Vigo University Hospital Complex, Spain, with radical surgery and post-operative radiotherapy, between 1995 and 2004. Results: The 3-year actuarial survival was 47.8 % and the adjusted actuarial survival was 60.8 %. Permanent local tumour control was achieved in 60.8 % of cases (14/23). Local tumour recurrence was the main cause of treatment failure (33.3 %; 4/12). The most significant prognostic factors affecting local tumour control and survival were: clinical stage (P<.031), suprastructural location of the tumour (P<.001), and presence of positive resection margins (P<.001). Conclusions: Local recurrence was found to be very high and generally the main cause of death. New treatment protocols should be assessed