Detalles de la búsqueda
1.
Bioavailability of acalabrutinib suspension delivered via nasogastric tube in the presence or absence of a proton pump inhibitor in healthy subjects.
Br J Clin Pharmacol
; 88(10): 4573-4584, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35466438
2.
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans.
Xenobiotica
; 51(7): 796-810, 2021 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-33938357
3.
Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor.
Br J Clin Pharmacol
; 85(8): 1751-1760, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30973970
4.
A Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors.
Oncologist
; 22(12): 1491-1499, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28798270
5.
A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study).
Cancer
; 122(22): 3519-3528, 2016 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27603005
6.
Pharmacogenomics in the age of personalized medicine.
Drug Discov Today Technol
; 21-22: 11-16, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27978982
7.
Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.
Drug Metab Dispos
; 43(4): 490-509, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25587128
8.
Evaluation of metabolism and disposition of GDC-0152 in rats using 14C labeling strategy at two different positions: a novel formation of hippuric acid from 4-phenyl-5-amino-1,2,3-thiadiazole.
Drug Metab Dispos
; 41(2): 508-17, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23223496
9.
Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs--reversing the effect of elevated gastric pH with betaine HCl.
Mol Pharm
; 10(11): 4024-31, 2013 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-23980865
10.
Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria.
Mol Pharm
; 10(11): 4032-7, 2013 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-23980906
11.
Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development.
Mol Pharm
; 10(11): 4055-62, 2013 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-24044612
12.
Impact of food and the proton pump inhibitor rabeprazole on the pharmacokinetics of GDC-0941 in healthy volunteers: bench to bedside investigation of pH-dependent solubility.
Mol Pharm
; 10(11): 4074-81, 2013 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-24099279
13.
Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis.
Hepatology
; 54(2): 644-54, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21538436
14.
Quantitative systems pharmacology model-based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3-kinase inhibitors.
CPT Pharmacometrics Syst Pharmacol
; 11(5): 616-627, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34850607
15.
Evaluation of the Pharmacokinetics and Safety of a Single Dose of Acalabrutinib in Subjects With Hepatic Impairment.
J Clin Pharmacol
; 62(6): 812-822, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34897701
16.
Bioequivalence and Relative Bioavailability Studies to Assess a New Acalabrutinib Formulation That Enables Coadministration With Proton-Pump Inhibitors.
Clin Pharmacol Drug Dev
; 11(11): 1294-1307, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36029150
17.
Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors.
Cancer Chemother Pharmacol
; 88(3): 451-464, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34080039
18.
Intrinsic and Extrinsic Pharmacokinetic Variability of Small Molecule Targeted Cancer Therapy.
Clin Transl Sci
; 13(2): 410-418, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31729137
19.
Breast cancer resistance protein substrate and inhibition evaluation: why, when, and how?
Drug Metab Dispos
; 42(12): 1979-80, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25362071
20.
Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2.
Mol Pharm
; 6(6): 1790-7, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19400585