Physical evaluation of a new technique for X-ray dose reduction: measurement of signal-to-noise ratio and modulation transfer function in an animal model.

Aim of this study was to record objective changes in image quality of optically re-exposed, radiation-reduced X-ray images in comparison to a normally exposed reference image in an animal model. Under investigation is the question if optical re-exposure of conventional, radiation-reduced X-ray images partially or even fully compensates the loss of information caused by underexposure. Dose-reduced, underexposed images were prepared by reducing the mAs product to 50% with constant anode voltage. Reproduction of the image was performed with a 52% decrease in the radiation dose. Comparing different re-exposure times, the optimal time was found to be 60s. These underexposed X-rays were then optically re-exposed for a defined period of time before development. In all X-ray images of the animal model, different osseous structures were defined as regions of interest (ROI) for evaluation of the objective changes in image quality. The density curves were plotted with the two-beamed densitometer. The contrast transfer factors as the function of local frequency were determined from this, which served as the basis for calculating the modulation transfer factor. To establish if X-ray sensitisation by optical re-exposure leads to a change in the sensitometric gradation, the sensitometric curves were determined using a standardized aluminum scale and thermal luminescence dosimetry. In the comparison the lowest correlation with the standard technique film (X-ray 1) was seen in the purely dose-reduced X-ray. In the range of 1.6-3.4Lp/mm, both SNR curves have an identical course. Despite a 52% dose reduction in the re-exposed image, both densitometry curves of the conventional and re-exposed X-ray show an almost identical distribution of the transmittance levels. In conclusion film sensitisation provides a technically simple and inexpensive procedure, which is easily integrated into previous film development processes and considerably reduces the patient radiation exposure as well as clearly improving the image quality.

Three-dimensional load measurements in an external fixator.

On the basis of a six-degree-of-freedom adjustable fracture reduction hexapod external fixator, a system which can be used for measuring axial and shear forces as well as torsion and bending moments in the fixator in vivo was developed. In a pilot study on 9 patients (7 fresh fractures and 2 osteotomies of the tibia), the load in the fixator during the healing process was measured after 2, 4, 8 and 12 weeks and at fixator removal. The measured values enabled both the type of fracture to be determined as well as the monitoring of the healing process. In well-reduced type A3 fractures small axial (direction of the bone axis) forces were found in the fixator. A2, B2 and C3 fractures showed distinct axial forces, which decreased during the healing process, according to an increasing load transfer over the bone. Bending moments in the fixator showed good correspondence with the clinical healing process, except in the case of a C3 fracture. A combination of bending moment and axial force proved to be particularly suitable to assess fracture healing. In transverse fractures, the well-known resorption phenomenon of bone in the fracture gap at approximately 4 weeks was detected by the system. Compared with other external fixator load measurements in vivo, the hexapod offers the advantage of being able to measure all forces and moments in the fixator separately and with a relatively simple mechanical arrangement. In our opinion, it will be possible to control fracture healing using this system, thereby minimizing radiation exposure from radiographs. Furthermore, the measurement system is a step towards the development of external fixator systems that enable automatic adjustments of the callus mechanical situation ("automatic dynamization") and inform the patients about the optimal weight bearing of their extremity ("intelligent fixator").

Prevention of thromboembolism with low-molecular-weight heparin in orthopedic surgery: a 5-year experience.

A regimen of prophylaxis of thromboembolism with low molecular weight heparin (LMWH) and unfractionated heparin (UFH) in orthopedic surgery is presented. Over a 5-year period, 11,905 patients have been operated in all fields of orthopedic surgery in a big trauma center. In 498 cases, deep vein thrombosis (DVT) was clinically suspected and phlebography was performed: 122 patients had confirmed DVT (rate 0.98%); 59.8% of the DVT were limited to the calf. Nineteen pulmonary embolisms (rate 0.16%) were diagnosed (3 lethal). Heparin-induced thrombocytopenia type II was diagnosed in 12 of 122 patients. Only one of these had received LMWH. The related rates of DVT were highest for tibial head fractures (12.4%), total knee replacement (6.7%), and multiple trauma (6.4%). The extent of DVT was most severe in multiple trauma. The results proved the regimen to be of good clinical use and showed that more attention has to be paid to fractures, especially of the knee; and to patients with multiple injuries.

[Loss of extremities caused by heparin-induced thrombocytopenia]. / Extremitätenverluste bei heparininduzierter Thrombozytopenie.

We report the cases of two patients who last lims as a result of heparin-induced thrombocytopenia (HIT). On the basis of these cases, the incidence, pathophysiology and the diagnosis of HIT are reviewed. For the diagnosis of HIT, the platelet aggregation test and ELISA are used. For HIT prophylaxis and treatment of thromboembolic complications is recommended Orgaran. Exact dosage schedules are provided.

[Aplasia of the articular process of the 2nd cervical vertebra]. / Aplasie eines gelenkfortsatzes am 2. halswirbelkörper.

The X-ray diagnosis of a contusion of the cervical spine showed unilateral aplasia of the inferior articular process of C2 in a 7-year-old boy. The literature, diagnosis and differential diagnosis are discussed.

[Simultaneous traumatic rupture of the patellar and contralateral quadriceps tendon]. / Simultane traumatische Patellarsehnen- und kontralaterale Quadrizepssehnenruptur.

We report a very rare case of a simultaneous rupture of the right patellar and left quadriceps tendon in an otherwise healthy 37-year-old patient, who jumped off a kickboard. Suture of both tendons was performed on the day of trauma. We describe our postoperative treatment and report the follow-up examination one year after the trauma. Beside functional questionnaire, Lysholm score and physical examination and x-ray, quadriceps isokinetic testing was performed.

Quadriceps tendon ruptures-is there a complete functional restitution?

From January 1986 to November 1999, 35 patients with 36 traumatic ruptures of the quadriceps tendon, all without medical risk factors, were treated (33 men, 2 women; mean age 55 years). Thirty patients were operated within 14 days after trauma. With an average follow up of 55.4 months (7-168) 29 of 30 still living patients (96.7%) were studied retrospectively. Questionnaire (Lysholm score), physical examination, X-ray of both knees and isokinetic testing were performed. The outcome was significantly (P < 0.001) dependent on the time of operative procedure. Twenty-four patients treated within the first 14 days had 20 excellent and 4 good results, the other 5 one good, 1 satisfying and 3 poor results. Twenty-one of 23 patients (91%) could return to work. The type of repair (direct or transosseous suture with or without augmentation), the kind of postoperative physiotherapy, the age and the body mass index had no influence on the final outcome.

A hexapod robot external fixator for computer assisted fracture reduction and deformity correction.

Using hexapod robot kinematics, an external fixator adjustable in all six spatial degrees of freedom was developed. As usual with a robot system, bone movements can be accomplished with high precision. Contrary to conventional external fixators any three-dimensional movement is realisable without giving up stability or the necessity to change parts of the construction during the treatment. At first a manually controlled fixator with appropriate software was developed. Then electromotor elements were added, resulting in a "fracture reduction robot" and a fixator featuring load measurement capabilities was built. Finally the concept was extended into an "intelligent fixator" which will accomplish automatically controlled fracture and deformity treatment in the future.