1.
2.
Pharmazie
; 46(6): 424-6, 1991 Jun.
Artículo
en Alemán
| MEDLINE
| ID: mdl-1763120
RESUMEN
A well known side effect of the long-term therapy with phenytoin is gum hyperplasia. 1-Acyl compounds and esters of the p-hydroxymetabolite with aliphatic and aromatic carboxylic acids were synthesized as potential prodrugs for therapeutic use if the neoformation of connective tissue is intended. The compounds were characterized by there physico-chemical constants and the absorption was proofed by a buccal test.
Asunto(s)
Fenitoína/análogos & derivados , Fenitoína/administración & dosificación , Absorción , Administración Bucal , Hidrólisis , Fenitoína/farmacocinética , Profármacos/síntesis química , Solubilidad
3.
Pharmazie
; 42(7): 452-5, 1987 Jul.
Artículo
en Alemán
| MEDLINE
| ID: mdl-3671469
RESUMEN
An in-vitro model is presented which consists on several membrane Layers. The penetration of drugs from the ointment bases into these membrane Layers is observed. By combination of different membranes this system can be varied. In model calculations the resulting conditions are demonstrated.