Detalles de la búsqueda
1.
Relacorilant, a Selective Glucocorticoid Receptor Modulator in Development for the Treatment of Patients With Cushing Syndrome, Does Not Cause Prolongation of the Cardiac QT Interval.
Endocr Pract
; 30(1): 11-18, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-37805100
2.
Omecamtiv mecarbil does not prolong QTc intervals at therapeutic concentrations.
Br J Clin Pharmacol
; 88(1): 187-198, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34131942
3.
E2027 Cardiac Safety Evaluation With Concentration-Response Modeling of ECG Data to Inform Dose Selection in Studies in Patients With Dementia With Lewy Bodies.
Alzheimer Dis Assoc Disord
; 36(3): 208-214, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35622456
4.
Intravenous Amisulpride Does Not Meaningfully Prolong the QTc Interval at Doses Effective for the Management of Postoperative Nausea and Vomiting.
Anesth Analg
; 132(1): 150-159, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31913911
5.
Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study of the Effects of Omadacycline on QT/QTc Intervals in Healthy Subjects.
Antimicrob Agents Chemother
; 63(10)2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31405867
6.
Estimation of age effect with change-points on survival of cancer patients.
Stat Med
; 37(10): 1732-1743, 2018 05 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29468716
7.
Independence screening for high dimensional nonlinear additive ODE models with applications to dynamic gene regulatory networks.
Stat Med
; 37(17): 2630-2644, 2018 07 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-29722041
8.
Variable Selection for Sparse High-Dimensional Nonlinear Regression Models by Combining Nonnegative Garrote and Sure Independence Screening.
Stat Sin
; 24(3): 1365-1387, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25170239
9.
Concentration-QTcF Modeling of Icenticaftor from a Randomized, Placebo- and Positive-Controlled Thorough QT Study in Healthy Participants.
Clin Pharmacol Drug Dev
; 13(5): 572-584, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38284433
10.
Evaluation of Deutetrabenazine's Potential to Delay Cardiac Repolarization Using Concentration-QTc Analysis.
Clin Pharmacol Drug Dev
; 12(1): 94-106, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36098670
11.
A randomized, single-dose, crossover study of the effects of ulotaront on electrocardiogram intervals in subjects with schizophrenia.
Clin Transl Sci
; 16(6): 1063-1074, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36949248
12.
Concentration-QTc Relationship from a Single Ascending Dose Study of ANAVEX3-71, a Novel Sigma-1 Receptor and Allosteric M1 Muscarinic Receptor Agonist in Development for the Treatment of Frontotemporal Dementia, Schizophrenia, and Alzheimer's Disease.
Clin Pharmacol Drug Dev
; 12(9): 888-901, 2023 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-37515316
13.
Numerical discretization-based estimation methods for ordinary differential equation models via penalized spline smoothing with applications in biomedical research.
Biometrics
; 68(2): 344-52, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22376200
14.
A Phase 1 Clinical Study Evaluating the Effects of Cenobamate on the QT Interval.
Clin Pharmacol Drug Dev
; 11(4): 523-534, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35182037
15.
A Phase 1 Thorough QT/QTc Study of Therapeutic and Supratherapeutic Doses of Belumosudil in Healthy Subjects.
Clin Pharmacol Drug Dev
; 11(10): 1221-1232, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35881051
16.
ECG Evaluation as Part of the Clinical Pharmacology Strategy in the Development of New Drugs: A Review of Current Practices and Opportunities Based on Five Case Studies.
J Clin Pharmacol
; 62(12): 1480-1500, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35665514
17.
A thorough QTc study to evaluate the effects of oral rilzabrutinib administered alone and with ritonavir in healthy subjects.
Clin Transl Sci
; 15(6): 1507-1518, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35301810
18.
Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK-906), a Novel Selective D2 /D3 Receptor Antagonist: A Phase 1 Randomized, Placebo-Controlled Single- and Multiple-Dose Escalation Study in Healthy Participants.
Clin Pharmacol Drug Dev
; 10(8): 927-939, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33462988
19.
Evaluation of the Potential for QTc Prolongation With Repeated Oral Doses of Fedratinib in Patients With Advanced Solid Tumors.
Clin Pharmacol Drug Dev
; 10(4): 366-375, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32673446
20.
Sieve Estimation of Constant and Time-Varying Coefficients in Nonlinear Ordinary Differential Equation Models by Considering Both Numerical Error and Measurement Error.
Ann Stat
; 38(4): 2351-2387, 2010 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21132064