Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 6 de 6
Filtrar
1.
Hong Kong Med J ; 25(5): 372-381, 2019 10.
Artículo en Inglés | MEDLINE | ID: mdl-31619576

RESUMEN

INTRODUCTION: This study was conducted to evaluate sexual function in adult survivors of childhood cancers and investigate possible relationships between sexual function and quality of life, as measured by general well-being, self-esteem, body image, and depressive symptoms. METHODS: This cross-sectional survey was performed in our centre from 14 August 2015 to 8 September 2017. Adult patients who had a history of childhood cancers, and who were disease-free for >3 years, were approached for the study during clinical follow-up. Clinical information was collected from medical records. Self-administered questionnaires regarding quality of life and sexual functioning were given to the patients and resulting data were analysed. RESULTS: Two hundred patients agreed to participate in the study. The overall response rate was 64.8%. Ninety-one (45.5%) patients were women, and the mean age was 25.4 ± 5.57 years. The overall sexual functioning score was 28.3 ± 20.09. Forty-eight (24.0%) patients reported at least one sexual problem. Among patients who reported no sexual problems, more had haematological cancers (P=0.009), fewer underwent surgery (P=0.004), fewer underwent surgery with external effects (P=0.032), and fewer were regular social drinkers (P=0.013); additionally, they had a higher mean Rosenberg self-esteem scale score (P=0.010), lower mean body image scale score (P=0.008), and lower mean Patient Health Questionnaire score (P=0.001). CONCLUSION: Aspects of life beyond disease condition and physical function should be considered in adult survivors of childhood cancers. Appropriate referral and intervention should be initiated for these patients when necessary.


Asunto(s)
Supervivientes de Cáncer , Neoplasias/fisiopatología , Neoplasias/psicología , Calidad de Vida , Autoimagen , Disfunciones Sexuales Fisiológicas/etiología , Adulto , Consumo de Bebidas Alcohólicas , Imagen Corporal , Niño , Estudios Transversales , Depresión , Femenino , Hong Kong , Humanos , Modelos Lineales , Masculino , Encuestas y Cuestionarios , Adulto Joven
2.
J Ethnopharmacol ; 118(2): 324-30, 2008 Jul 23.
Artículo en Inglés | MEDLINE | ID: mdl-18550308

RESUMEN

AIMS OF THE STUDY: Ganoderma lucidum possesses significant antioxidant and anti-cancer properties. The effects of Lingzhi antioxidants on oxidative DNA damage and oxidative stress were investigated, in order to understand their roles in bladder chemoprevention. MATERIALS AND METHODS: Antioxidant-enhanced extracts were tested, in terms of ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH.) inhibition, hydrogen peroxide (H(2)O(2)) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentrations, and cytotoxicity, using an in vitro pre-cancerous human uroepithelial cell (HUC-PC) tumorigenic model. RESULTS: Water-soluble extract (GLw) possesses relatively higher antioxidant capacities than the water-insoluble counterpart (GLe); however, under the challenge of carcinogenic 4-aminobiphenyl (ABP), GLw reduced the 8-OHdG concentration in HUC-PC culture, while GLe induced the formation of H(2)O(2) and 8-OHdG in a dose-dependent manner. The modern theory of antioxidant-oxidant balance seems to obey the theory of Yin-Yang in traditional Chinese medicine (TCM). CONCLUSIONS: Water-soluble and water-insoluble components of Ganoderma lucidum exhibited dual roles in oxidative DNA damage. Oxidative DNA damage may be an underlying mechanism of Lingzhi-induced apoptosis in bladder chemoprevention.


Asunto(s)
Antioxidantes/farmacología , Medicamentos Herbarios Chinos/farmacología , Estrés Oxidativo/efectos de los fármacos , Reishi/química , 8-Hidroxi-2'-Desoxicoguanosina , Compuestos de Aminobifenilo/toxicidad , Antioxidantes/administración & dosificación , Antioxidantes/aislamiento & purificación , Línea Celular , Daño del ADN/efectos de los fármacos , Desoxiguanosina/análogos & derivados , Desoxiguanosina/metabolismo , Relación Dosis-Respuesta a Droga , Medicamentos Herbarios Chinos/administración & dosificación , Medicamentos Herbarios Chinos/aislamiento & purificación , Compuestos Férricos/química , Humanos , Peróxido de Hidrógeno/metabolismo , Urotelio/citología , Urotelio/efectos de los fármacos , Urotelio/metabolismo
3.
J Ethnopharmacol ; 223: 113-121, 2018 Sep 15.
Artículo en Inglés | MEDLINE | ID: mdl-29783018

RESUMEN

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (GL) has been traditionally used in oriental medicine as superior health tonic, and there are numerous scientific evidences of its antitumorigenic activities. AIM OF THE STUDY: To evaluate the intravesical chemopreventive effects of ethanol extract of GL (GLe) on bladder cancer. MATERIALS AND METHODS: Intravesical therapy is defined as the direct instillation of a liquid drug into bladder through a catheter. Bacille Calmette-Guerin(BCG) solution is applied intravesically as a conventional immunotherapy for preventing recurrence of bladder cancer. By adopting the MB49/C57 bladder cancer mice model, an overall 60 MB49-implanted mice were randomized into 3 groups and treated according to 3 treatment arms, including GLe, BCG and PBS. Additionally, wild-type mice without MB49 cell inoculation and treated with PBS were used as the negative control group. Testing agents were instilled intravesically for 2 h and repeated after one week for evaluating the effects on preventing the tumor formation and growth. The treated-mice were closely monitored for major adverse effects. RESULTS: GLe demonstrated more potent cytotoxic effects than BCG on MB49 cells, although both in dose-dependent manner. In the MB49-implanted mice, 80 µg/ml GLe was shown to delay the tumor formation by one week, whereas the averaged tumor volume measured at endpoint was 3.6-fold and 4.6-fold smaller than that of the BCG or PBS, respectively. However, no significant effects were observed on body weight and hematuria. CONCLUSION: Current findings in mice suggested intravesical GLe therapy as an effective and safe chemopreventive strategy for inhibiting bladder tumor formation.


Asunto(s)
Anticarcinógenos/uso terapéutico , Antineoplásicos/uso terapéutico , Reishi , Neoplasias de la Vejiga Urinaria/tratamiento farmacológico , Animales , Línea Celular Tumoral , Supervivencia Celular , Modelos Animales de Enfermedad , Femenino , Ratones Endogámicos C57BL
4.
Complement Ther Med ; 23(1): 46-54, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-25637152

RESUMEN

OBJECTIVE: To conduct a community-based survey to describe the demographics, experience, and utilization variables among the users of gua sha living in Hong Kong. METHOD: A total of 3209 adult respondents were surveyed by using a short Chinese questionnaire. RESULTS: Gua sha was found to have a one-year prevalence of 22.7% and four-week prevalence of 6.6%. The users were seen to be old of age and less educated. The majority believed that gua sha is beneficial to health, practiced in non-regular basis, and mainly employed for treating illnesses. For both male and female, the top two common illnesses to be treated were the respiratory and pain problems, which accounting for 74% of all users. Other illnesses included nervousness, heat stroke, fever, infection, dizziness, diarrhoea and vomiting, oedema, and constipation. As practiced by most respondents, unidirectional pressured stroking was applied repeatedly on the lubricated skin surface at the back region using various smooth-edged tools typically spoons. Almost all users reported the occurrence of skin blemishing and subsequently faded within 7 days after the gua sha treatment. CONCLUSION: The general population of Hong Kong was found to have high prevalence of gua sha usage. The utilization characteristics as reported by the users were generally aligned with the current scientific knowledge, in particular the treatment procedures and response.


Asunto(s)
Medicina Tradicional China/métodos , Adolescente , Adulto , Anciano , Recolección de Datos , Femenino , Hong Kong/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Características de la Residencia , Piel , Adulto Joven
5.
Free Radic Res ; 37(11): 1209-13, 2003 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-14703733

RESUMEN

The level of hydrogen peroxide (H2O2) in urine has been suggested as a potential biomarker of whole body oxidative stress, but issues of stability, reproducibility and biological variation have not been investigated to date. In this study, we used a refined protocol, which demonstrated improved sensitivity and precision, to determine the stability of H2O2 in urine, and to measure its concentration in apparently healthy subjects. We also investigated intra-individual variation within and between days. Results showed that H2O2 in urine is stable for up to 48 h at 4 degrees C, however, storage of urine at room temperature was associated with up to 50% increase in H2O2 concentration over a few hours. Total H2O2 in freshly voided urine from 55 healthy, fasting subjects ranged from 0.84 to 5.71 microM, or 90-1164 micromol H2O2/mol creatinine. Intra-individual variation was wide. Even when concentration corrected and collected at the same time of day, 2- to 3-fold variation was seen over 4 consecutive days, and over the course of a single day the creatinine-corrected H2O2 also varied significantly. We suggest that this large biological variation limits the usefulness of urine H2O2 as a biomarker of oxidative stress, the exception being when the effects of disease, therapy or diet induce very large changes in its concentration.


Asunto(s)
Peróxido de Hidrógeno/orina , Estrés Oxidativo , Adulto , Biomarcadores/orina , Femenino , Humanos , Masculino , Persona de Mediana Edad
6.
J Ethnopharmacol ; 135(3): 711-8, 2011 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-21501679

RESUMEN

AIMS OF THE STUDY: Ganoderma lucidum is active to stimulate immunological effector cells, but the effects on uroepithelial cells have never been explored. The present study compared the expression of major cytokines induced by the water (GLw) and ethanol (GLe) extracts of G. lucidum. MATERIALS AND METHODS: The pre-cancerous human uroepithelial cell (HUC-PC) line was employed. A total of 15 cytokines, including major Th1/Th2 cytokines and chemokines, were measured in the complete media after 24h incubation with GLw and GLe. Additionally, the following assays were performed: cytotoxicity, apoptosis, migration of neutrophils, and nuclear factor-kappaB (NF-κB) DNA binding activity. RESULTS: GLe inhibited the growth of HUC-PC cells through apoptosis. Interleukins IL-2, IL-6, and IL-8 were significantly up-regulated by GLe in dose-dependent manners, but not by GLw. However, MCP-1 level was significantly increased by GLw but was oppositely reduced by GLe. Furthermore, the elevation of cytokine expression was correlated with the enhancement of p50/p65 NF-κB activity induced by GLe. The elevated IL-8 levels in GLe-treated cells were also correlated with the migration of neutrophils. CONCLUSIONS: GLe and GLw exhibited different immunological activities on the HUC-PC cells. In particular, the activities of GLe may favor the clearance of high risk urothelial cells, suggesting potent chemopreventive ingredients are extractable by ethanol from G. lucidum.


Asunto(s)
Anticarcinógenos/uso terapéutico , Proliferación Celular/efectos de los fármacos , Citocinas/metabolismo , Fitoterapia , Lesiones Precancerosas/tratamiento farmacológico , Reishi , Neoplasias Urológicas/prevención & control , Urotelio/efectos de los fármacos , Anticarcinógenos/farmacología , Apoptosis/efectos de los fármacos , Productos Biológicos/farmacología , Productos Biológicos/uso terapéutico , Línea Celular , Quimiocina CCL2/metabolismo , Relación Dosis-Respuesta a Droga , Humanos , Interleucinas/metabolismo , FN-kappa B/metabolismo , Infiltración Neutrófila/efectos de los fármacos , Lesiones Precancerosas/inmunología , Neoplasias Urológicas/inmunología , Urotelio/inmunología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA