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1.
Liver Int ; 37(12): 1823-1832, 2017 12.
Artículo en Inglés | MEDLINE | ID: mdl-28481460

RESUMEN

BACKGROUND AND AIMS: Hepatitis C (HCV) therapy with Sofosbuvir (SOF)/Simeprevir (SMV) in clinical trials and real-world clinical practice, showed high rates of sustained virological response (SVR) in non-cirrhotic genotype (GT)-1 and GT-4 patients. These results were slightly lower in cirrhotic patients. We investigated real-life effectiveness and safety of SOF/SMV with or without ribavirin (RBV) in a large cohort of cirrhotic patients. METHODS: This collaborative multicentre study included data from 968 patients with cirrhosis infected with HCV-GT1 or 4, treated with SOF/SMV±RBV in 30 centres across Spain between January-2014 and December-2015. Demographic, clinical, virological and safety data were analysed. RESULTS: Overall SVR was 92.3%; the majority of patients were treated with RBV (62%) for 12 weeks (92.4%). No significant differences in SVR were observed between genotypes (GT1a:94.3%; GT1b:91.7%; GT4:91.1%). Those patients with more advanced liver disease (Child B/C, MELD≥10) or portal hypertension (platelet count≤100×109 /L, transient elastography≥21 Kpa) showed significantly lower SVR rates (84.4%-91.9%) than patients with less advanced liver disease (93.8%-95.9%, P<.01 in all cases). In the multivariate analysis, the use of RBV, female gender, baseline albumin≥35 g/L, MELD<10 and lack of exposure to a triple therapy regimen were independent predictors of SVR (P<.05). Serious adverse events (SAEs) and SAE-associated discontinuation events occurred in 5.9% and 2.6%. CONCLUSIONS: In this large cohort of cirrhotic patients managed in the real-world setting in Spain, SOF/SMV±RBV yielded to excellent SVR rates, especially in patients with compensated liver cirrhosis. In addition, this combination showed to be safe, with low rates of SAEs and early discontinuations.


Asunto(s)
Antivirales/uso terapéutico , Hepatitis C/tratamiento farmacológico , Sistema de Registros , Simeprevir/uso terapéutico , Sofosbuvir/uso terapéutico , Adulto , Anciano , Anciano de 80 o más Años , Quimioterapia Combinada , Femenino , Hepacivirus/genética , Hepatitis C/genética , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento , Adulto Joven
2.
J Clin Ultrasound ; 35(7): 405-8, 2007 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-17354246

RESUMEN

We report the case of a 74-year-old woman with elevated liver enzyme levels in whom abdominal sonographic examination revealed a diffusely heterogeneous liver parenchyma and multiple hypoechoic subcentimetric splenic nodules. Contrast-enhanced sonography (CEUS) revealed that the splenic focal lesions did not enhance. CT examination revealed a low-density, multinodular pattern both in the liver and in the spleen. Core biopsy of 1 hepatic nodule revealed noncaseating epithelioid cell granuloma, and the patient was diagnosed with systemic sarcoidosis. CEUS has shown to be useful in the diagnosis of focal hepatic lesions, but studies referring to splenic lesions are lacking.


Asunto(s)
Medios de Contraste/administración & dosificación , Sarcoidosis/diagnóstico , Bazo/diagnóstico por imagen , Enfermedades del Bazo/diagnóstico , Anciano , Fosfatasa Alcalina/sangre , Biopsia , Sedimentación Sanguínea , Proteína C-Reactiva , Diabetes Mellitus , Diagnóstico Diferencial , Células Epitelioides/patología , Femenino , Granuloma/complicaciones , Granuloma/diagnóstico , Humanos , Hiperlipidemias/complicaciones , Aumento de la Imagen/métodos , Hígado/diagnóstico por imagen , Hígado/patología , Fosfolípidos , Sarcoidosis/complicaciones , Hexafluoruro de Azufre , Tomografía Computarizada por Rayos X , Ultrasonografía , gamma-Glutamiltransferasa/sangre
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