Cloning, tissue expression and imprinting status analysis of the NDN gene in Dolang sheep.

BACKGROUND: Genomic imprinting refers to expressing parent-specific genes in mammalian diploid cells. The NDN gene is maternally imprinted in humans and mice and correlates with the timing of puberty. This study aimed to investigate its imprinting status and its relationship with the onset of puberty in Dolang sheep. METHODS AND RESULTS: In this study, cloning and sequencing obtained the NDN gene cDNA sequence of 1082 bp of Dolang sheep, coding for 325 amino acids. Similarity analysis and phylogenetic tree showed that the NDN gene conformed to the law of speciation and was highly conserved among mammals. RT-qPCR results showed the highest expression of NDN mRNA was found in the hypothalamus at puberty, and the expression was significantly increased and then significantly decreased from prepuberty to postpuberty in the hypothalamus, pituitary, and ovary and oviduct. Based on expressed single nucleotide polymorphism (SNP), the NDN gene was expressed monoallelically in the tissues of adult and neonatal umbilical cords, and the expressed allele was paternally inherited. The NDN promoter region of 3400 bp was obtained by cloning and identified in monoallelic-expressing tissues (hypothalamus, ovary, spleen) as a differentially methylated region (DMR). CONCLUSION: These findings will enrich the number of imprinted genes in sheep and suggest that the NDN gene could be a candidate gene for studying puberty initiation in Dolang sheep.

Provisioning of Fog Computing over Named-Data Networking in Dynamic Wireless Mesh Systems.

Fog computing is today considered a promising candidate to improve the user experience in dynamic on-demand computing services. However, its ubiquitous application would require support for this service in wireless multi-hop mesh systems, where the use of conventional IP-based solutions is challenging. As a complementary solution, in this paper, we consider a Named-Data Networking (NDN) approach to enable fog computing services in autonomous dynamic mesh formations. In particular, we jointly implement two critical mechanisms required to extend the NDN-based fog computing architecture to wireless mesh systems. These are (i) dynamic face management systems and (ii) a learning-based route discovery strategy. The former makes it possible to solve NDN issues related to an inability to operate over a broadcast medium. Also, it improves the data-link layer reliability by enabling unicast communications between mesh nodes. The learning-based forwarding strategy, on the other hand, efficiently reduces the amount of overhead needed to find routes in the dynamically changing mesh networks. Our numerical results show that, for static wireless meshes, our proposal makes it possible to fully benefit from the computing resources sporadically available up to several hops away from the consumer. Additionally, we investigate the impacts of various traffic types and NDN caching capabilities, revealing that the latter result in much better system performance while the popularity of the compute service contributes to additional performance gains.

Hormonal Imbalances in Prader-Willi and Schaaf-Yang Syndromes Imply the Evolution of Specific Regulation of Hypothalamic Neuroendocrine Function in Mammals.

The hypothalamus regulates fundamental aspects of physiological homeostasis and behavior, including stress response, reproduction, growth, sleep, and feeding, several of which are affected in patients with Prader-Willi (PWS) and Schaaf-Yang syndrome (SYS). PWS is caused by paternal deletion, maternal uniparental disomy, or imprinting defects that lead to loss of expression of a maternally imprinted region of chromosome 15 encompassing non-coding RNAs and five protein-coding genes; SYS patients have a mutation in one of them, MAGEL2. Throughout life, PWS and SYS patients suffer from musculoskeletal deficiencies, intellectual disabilities, and hormonal abnormalities, which lead to compulsive behaviors like hyperphagia and temper outbursts. Management of PWS and SYS is mostly symptomatic and cures for these debilitating disorders do not exist, highlighting a clear, unmet medical need. Research over several decades into the molecular and cellular roles of PWS genes has uncovered that several impinge on the neuroendocrine system. In this review, we will discuss the expression and molecular functions of PWS genes, connecting them with hormonal imbalances in patients and animal models. Besides the observed hormonal imbalances, we will describe the recent findings about how the loss of individual genes, particularly MAGEL2, affects the molecular mechanisms of hormone secretion. These results suggest that MAGEL2 evolved as a mammalian-specific regulator of hypothalamic neuroendocrine function.

Blockchain Private File Storage-Sharing Method Based on IPFS.

Under the current national network environment, anyone can participate in publishing. As an important information resource, knowledge files reflect the workload of publishers. Moreover, high-quality knowledge files can promote the progress of society. However, pirated inferior files have the opposite effect. At present, most organizations use centralized servers to centrally manage the knowledge files released by users. In addition, it is necessary to introduce an untrusted third party to examine and encrypt the contents of files, which leads to an opaque process of file storage transactions, tampering with intellectual copyright, and the inability to have consistent systems of file management among institutions due to the lack of uniform standards for the same intellectual files. The purpose of this paper is to ensure the safe storage of knowledge files on the one hand and to realize efficient sharing of copyrighted files on the other hand. Therefore, this paper combines NDN (Named Data Network) technology with a distributed blockchain and an Interplanetary File System (IPFS) and proposes a blockchain knowledge file storage and sharing method based on an NDN. The method uses the NDN itself for the file content signature and encryption, thereby separating the file security and transmission process. At the same time, the method uses a flexible NDN reverse path forwarding and routing strategy, combining an IPFS private storage network to improve the safety of the encrypted data storage security. Finally, the method takes advantage of all participating nodes consensus and shares files in the synchronized blockchain to ensure traceability. This paper introduces the structure and principles of the method and describes the process of file upload and transfer. Finally, the performance of the method is compared and evaluated, and the advantages and disadvantages of the method and the future research direction are summarized.

Context-Aware Pending Interest Table Management Scheme for NDN-Based VANETs.

In terms of delivery effectiveness, Vehicular Adhoc NETworks (VANETs) applications have multiple, possibly conflicting, and disparate needs (e.g., latency, reliability, and delivery priorities). Named Data Networking (NDN) has attracted the attention of the research community for effective content retrieval and dissemination in mobile environments such as VANETs. A vehicle in a VANET application is heavily reliant on information about the content, network, and application, which can be obtained from a variety of sources. The information gathered can be used as context to make better decisions. While it is difficult to obtain the necessary context information at the IP network layer, the emergence of NDN is changing the tide. The Pending Information Table (PIT) is an important player in NDN data retrieval. PIT size is the bottleneck due to the limited opportunities provided by current memory technologies. PIT overflow results in service disruptions as new Interest messages cannot be added to PIT. Adaptive, context-aware PIT entry management solutions must be introduced to NDN-based VANETs for effective content dissemination. In this context, our main contribution is a decentralised, context-aware PIT entry management (CPITEM) protocol. The simulation results show that the proposed CPITEM protocol achieves lower Interest Satisfaction Delay and effective PIT utilization based on context when compared to existing PIT entry replacement protocols.

Context-Aware Naming and Forwarding in NDN-Based VANETs.

Vehicular ad-hoc network (VANET) is a technology that allows ubiquitous mobility to mobile users. Inter-vehicle communication is an integral component of intelligent transportation systems that enables a wide variety of applications where vehicles interact and cooperate with each other, from safety applications to non-safety applications. VANETs applications have different needs (e.g., latency, reliability, delivery priorities, etc.) in terms of delivery effectiveness. In the last decade, named data networking (NDN) gained the attention of the research community for effective content retrieval and dissemination in mobile environments such as VANETs. In NDN, the content's name has a vital role in storing and retrieving the content effectively and efficiently. In NDN-based VANETs, adaptive content dissemination solutions must be introduced that can make decisions related to forwarding, cache management, etc., based on context information represented by a content name. In this context, our main contributions are two-fold: (i) we present the hierarchical context-aware content-naming (CACN) scheme for NDN-based VANETs that enables naming the safety and non-safety applications, and (ii) we present a decentralized context-aware notification (DCN) protocol that broadcasts event notification information for awareness within the application-based geographical area. Simulation results show that the proposed DCN protocol succeeds in achieving reduced transmissions, bandwidth, and energy compared to existing critical contents dissemination protocols.

Secure Content Distribution with Access Control Enforcement in Named Data Networking.

NDN is one of the new emerging future internet architectures which brings up new solutions over today's internet architecture, facilitating content distribution, in-network caching, mobility support, and multicast forwarding. NDNs ubiquitous in-network caching allows consumers to access data directly from the intermediate router's cache. However, it opens content privacy problems since data packets replicated in the router are always accessible by every consumer. Sensitive contents in the routers should be protected and accessed only by authorized consumers. Although the content protection problem can be solved by applying an encryption-based access control policy, it still needs an efficient content distribution scheme with lower computational overhead and content retrieval time. We propose an efficient and secure content distribution (ES_CD), by combining symmetric encryption and identity-based proxy re-encryption. The analysis shows that our proposed scheme achieves content retrieval time reduction up to 20% for the cached contents in our network simulation environment and a slight computational overhead of less than 19 ms at the content producer and 9 ms at the consumer for 2 KB content. ES_CD provides content confidentiality and ensures only legitimate consumers can access the contents during a predefined time without requiring a trusted third party and keeping the content producer always online.

A Dual-Connectivity Mobility Link Service for Producer Mobility in the Named Data Networking.

With the exponential growth of Cyber-Physical Systems (CPSs) technologies, the Internet of Things (IoT) infrastructure has evolved from built-in static infrastructure to a flexible structure applicable to various mobile environments. In this Internet of Mobile Things (IoMT) environment, each IoT device could operate simultaneously as a provider and consumer of information, and could provide new services through the exchange of such information. Named Data Networking (NDN), which could request data by content name rather than location (IP address), is suitable for such mobile IoT environments. However, in the current Named Data Networking (NDN) specification, producer mobility is one of the major problems in need of remedy. Previously proposed schemes for producer mobility use an anchor to hide the producer's movement from consumers. As a result, they require a special anchor node and a signaling procedure to track the current locations of contents. A few anchorless schemes have also been proposed, but they still require mobility signaling and all NDN routers on the signaling path must understand the meaning of the signaling. We therefore propose an anchorless producer mobility scheme for the NDN. This scheme uses a dual-connectivity strategy that can be expressed as a soft handover. Whenever a producer changes its NDN Access Router (NAR), the new mobility link service located on the mobile producer's old NDN face repairs the old link so that the connectivity with the pNAR can be maintained for a while. The old NDN face is removed after the new location information on the contents of the producer is disseminated over the NDN network by the Named-data Link State Routing Protocol (NLSR) routing protocol at the nNAR. The new mobility link service decouples connection and transaction to hide the collapse of the link. Therefore, the NDN's mobility procedure could be simplified as the handover is defined as transaction completion as opposed to a breakdown of links. The proposed scheme prevents the routing information from being abruptly outdated due to producer mobility. Our simulation results show seamless handover when the producer changes its default access router.

PPCS: A Progressive Popularity-Aware Caching Scheme for Edge-Based Cache Redundancy Avoidance in Information-Centric Networks.

This article proposes a novel chunk-based caching scheme known as the Progressive Popularity-Aware Caching Scheme (PPCS) to improve content availability and eliminate the cache redundancy issue of Information-Centric Networking (ICN). Particularly, the proposal considers both entire-object caching and partial-progressive caching for popular and non-popular content objects, respectively. In the case that the content is not popular enough, PPCS first caches initial chunks of the content at the edge node and then progressively continues caching subsequent chunks at upstream Content Nodes (CNs) along the delivery path over time, according to the content popularity and each CN position. Therefore, PPCS efficiently avoids wasting cache space for storing on-path content duplicates and improves cache diversity by allowing no more than one replica of a specified content to be cached. To enable a complete ICN caching solution for communication networks, we also propose an autonomous replacement policy to optimize the cache utilization by maximizing the utility of each CN from caching content items. By simulation, we show that PPCS, utilizing edge-computing for the joint optimization of caching decision and replacement policies, considerably outperforms relevant existing ICN caching strategies in terms of latency (number of hops), cache redundancy, and content availability (hit rate), especially when the CN's cache size is small.

Using Linguistic Properties of Place Specification for Network Naming to Improve Mobility Performance.

By considering the definitions and properties from the field of linguistics regarding place specification, a questionnaire that can be used to improve naming in networks is obtained. The questionnaire helps introduce the idea of place specification from linguistics and the concept of metric spaces into network naming schemes. The questionnaire results are used to improve the basic Information-Centric Networking (ICN) architecture's notoriously lax network naming structure. The improvements are realized by leveraging components from the Named-Node Network Architecture, a minor ICN design, to supply the resulting network architecture with the properties the questionnaire highlights. Evaluation results from experiments demonstrate that modifying the network architecture so that the proposed questionnaire is satisfied results in achieving high mobility performance. Specifically, the proposed system can obtain mean application goodput at above 88 % of the ideal result, with a delay below 0.104 s and with the network time-out Interest ratio below 0.082 for the proposed single mobile push producer, single mobile consumer scenario, even when the nodes reach the maximum tested speed of 14 m/s.

A Trusted Lightweight Communication Strategy for Flying Named Data Networking.

Flying Ad hoc Network (FANET) is a new resource-constrained breed and instantiation of Mobile Ad hoc Network (MANET) employing Unmanned Aerial Vehicles (UAVs) as communicating nodes. These latter follow a predefined path called 'mission' to provide a wide range of applications/services. Without loss of generality, the services and applications offered by the FANET are based on data/content delivery in various forms such as, but not limited to, pictures, video, status, warnings, and so on. Therefore, a content-centric communication mechanism such as Information Centric Networking (ICN) is essential for FANET. ICN addresses the problems of classical TCP/IP-based Internet. To this end, Content-centric networking (CCN), and Named Data Networking (NDN) are two of the most famous and widely-adapted implementations of ICN due to their intrinsic security mechanism and Interest/Data-based communication. To ensure data security, a signature on the contents is appended to each response/data packet in transit. However, trusted communication is of paramount importance and currently lacks in NDN-driven communication. To fill the gaps, in this paper, we propose a novel trust-aware Monitor-based communication architecture for Flying Named Data Networking (FNDN). We first select the monitors based on their trust and stability, which then become responsible for the interest packets dissemination to avoid broadcast storm problem. Once the interest reaches data producer, the data comes back to the requester through the shortest and most trusted path (which is also the same path through which the interest packet arrived at the producer). Simultaneously, the intermediate UAVs choose whether to check the data authenticity or not, following their subjective belief on its producer's behavior and thus-forth reducing the computation complexity and delay. Simulation results show that our proposal can sustain the vanilla NDN security levels exceeding the 80% dishonesty detection ratio while reducing the generated end-to-end delay to less than 1 s in the worst case and reducing the average consumed energy by more than two times.

Disaster Management System Aided by Named Data Network of Things: Architecture, Design, and Analysis.

Disasters are the uncertain calamities which within no time can change the situation quite drastically. They not only affect the system's infrastructure but can also put an adverse effect on human life. A large chunk of the IP-based Internet of Things (IoT) schemes tackle disasters such as fire, earthquake, and flood. Moreover, recently proposed Named Data Networking (NDN) architecture exhibited promising results for IoT as compare to IP-based approaches. Therefore to tackle disaster management system (DMS), it is needed to explore it through NDN architecture and this is the main motivation behind this work. In this research, a NDN based IoT-DMS (fire disaster) architecture is proposed, named as NDN-DISCA. In NDN-DISCA, NDN producer pushes emergency content towards nearby consumers. To provide push support, Beacon Alert Message (BAM) is created using fixed sequence number. NDN-DISCA is simulated in ndnSIM considering the disaster scenario of IoT-based smart campus (SC). From results, it is found that NDN-DISCA exhibits minimal delay and improved throughput when compared to the legacy NDN and existing PUSH schemes.

Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study.

In the present study, we evaluated tumor-infiltrating lymphocytes (TILs) and blood regulatory T lymphocyte (Tregs, CD4+/CD25+/FoxP3+) expression in bladder cancer patients. The number of CD4+, CD8+, CD25+, FoxP3+ and CD20+ TILs was analyzed in association with clinico-pathomorphological features. In more advanced metastasizing tumors, showing non-classic differentiation (ND) and a more aggressive tissue invasion type (TIT), the number of TILs decreased. A low number of CD4+ TILs was associated with poor prognosis. Similarly, Treg frequency before surgery and after surgical treatment was significantly lower in more advanced tumors. The changes in TILs, as well as of local and systemic Tregs, were accompanied by changes in the histological phenotype of urothelial carcinoma regarding pT stage, NDs, TIT, and clinical outcomes. The number of TILs and the frequency of blood Tregs (indicators of antitumor response) may be essential for choosing an immunotherapy that is adjusted to the immune status according to the phase of tumor growth. Moreover, a significant reduction in the number of CD4+ and CD8+ TILs with the development of NDs in more advanced tumors may be associated with lower tumor immunogenicity, resulting in immune tolerance towards tumor tissue. These observations and the tendency of urothelial bladder carcinoma to undergo NDs in a heterogeneous manner during tumor progression suggest complex interactions between bladder cancer immunogenicity and stages of tumor progression.

Implication of locus coeruleus dysfunction in Prader-Willi syndrome: Insights from a mouse model.

Prader-Willi syndrome (PWS) is a multisystemic disorder. Notably, many characteristic symptoms of PWS are correlated with locus coeruleus norepinephrine system (LC-NE) dysfunction, including impairment in arousal, learning, pain modulation, and stress-induced negative affective states. Although electrophysiological experiments in necdin-deficient mice, an established PWS animal model, have revealed decreased spontaneous neuronal firing activity in the LC and impaired excitability, the behavioral phenotypes related to LC-NE dysfunction remain unexplored. In this study, heterozygous necdin-deficient mice (B6.Cg-Ndntm1ky) were bred from wild-type (WT) females to generate WT (+m/+p) and heterozygous (+m/-p) animals. Compared to WT mice, Ndn + m/-p mice demonstrated impaired visual-spatial memory in the Y-maze test, reduced social interaction, impaired sexual recognition, and shorter falling latency on the Rotarod. Using the open field test (OFT) and elevated plus maze (EPM), we observed similar locomotion activity of Ndn + m/-p and WT mice, but Ndn + m/-p mice were less anxious. After acute restraint, Ndn + m/-p mice exhibited significant impairment in stress-induced anxiety. Additionally, the plasma norepinephrine surge following exposure to acute restraint stress was also impaired. Pretreatment with atomoxetine, a norepinephrine reuptake inhibitor aimed to enhance LC function, restored Ndn + m/-p mice to exhibit a normal response to acute restraint stress. Furthermore, by employing chemogenetic approaches to facilitate LC neuronal firing, post-stress anxious responses were also partially rescued in Ndn + m/-p mice. These data strongly suggest that LC dysfunction is implicated in the pathogenesis of stress-related neuropsychiatric symptoms in PWS. Manipulation of LC activity may hold therapeutic potential for patients with PWS.

Controller-driven vector autoregression model for predicting content popularity in programmable named data networking devices.

Named Data Networking (NDN) has emerged as a promising network architecture for content delivery in edge infrastructures, primarily due to its name-based routing and integrated in-network caching. Despite these advantages, sub-optimal performance often results from the decentralized decision-making processes of caching devices. This article introduces a paradigm shift by implementing a Software Defined Networking (SDN) controller to optimize the placement of highly popular content in NDN nodes. The optimization process considers critical networking factors, including network congestion, security, topology modification, and flowrules alterations, which are essential for shaping content caching strategies. The article presents a novel content caching framework, Popularity-aware Caching in Popular Programmable NDN nodes (PaCPn). Employing a multi-variant vector autoregression (VAR) model driven by an SDN controller, PaCPn periodically updates content popularity based on time-series data, including 'request rates' and 'past popularity'. It also introduces a controller-driven heuristic algorithm that evaluates the proximity of caching points to consumers, considering factors such as 'distance cost,' 'delivery time,' and the specific 'status of the requested content'. PaCPn utilizes customized DATA named packets to ensure the source stores content with a valid residual freshness period while preventing intermediate nodes from caching it. The experimental results demonstrate significant improvements achieved by the proposed technique PaCPn compared to existing schemes. Specifically, the technique enhances cache hit rates by 20% across various metrics, including cache size, Zipf parameter, and exchanged traffic within edge infrastructure. Moreover, it reduces content retrieval delays by 28%, considering metrics such as cache capacity, the number of consumers, and network throughput. This research advances NDN content caching and offers potential optimizations for edge infrastructures.

COVID-19, Virtual Engagement and the Psychoid Imagination.

The impact of the COVID-19 pandemic on analytic training and the delivery of educational content is explored here. The proliferation of Zoom therapy and teaching is creating a post-human platform to which nearly everyone in contemporary society has had to adapt. Looking at the possible meanings of the pandemic, a psychoid factor (the virus) engaging the imagination has come to the fore as a response to climate change. The striking similarity to the H1N1 viral pandemic ("Spanish flu") is noted, especially in the context of C. G. Jung having had a case in 1919 during which he experienced a number of visions and dreams. The imagery produced can be seen as an implicit attempt at "re-enchanting the world" found in The red book. Finally, a reconsideration of pedagogy in response to the pandemic is discussed with an eye to the archetypal aspects of internet communications.

Cet article étudie l'impact de la pandémie de COVID-19 sur la formation des analystes et sur la manière dont le contenu éducatif est dispensé. La prolifération de thérapie et de formation par Zoom crée une plateforme post-humaine à laquelle quasiment toute personne dans la société contemporaine a eu à s'adapter. En regardant les sens possibles que l'on peut donner à la pandémie, un facteur psychoïde (le virus) qui mobilise l'imagination a pris le devant de la scène en tant que réponse au changement climatique. L'article souligne la similarité frappante avec la pandémie virale H1N1 (la grippe espagnole), particulièrement dans le contexte où C.G. Jung l'a attrapée en 1919 et a fait l'expérience d'un certain nombre de visions et de rêves. L'imagerie produite peut être vue comme une tentative implicite de « ré-enchanter le monde ¼ telle qu'on la trouve dans le Livre Rouge. En conclusion, une reconsidération de la pédagogie issue de la pandémie est discutée en tenant compte des aspects archétypaux des communications par internet.

Se exploran aquí las repercusiones de la pandemia de COVID-19 en la formación analítica y en la transmisión de contenidos educativos. La proliferación de la terapia y la enseñanza vía Zoom está creando una plataforma posthumana a la que casi todo el mundo en la sociedad contemporánea ha tenido que adaptarse. En cuanto a los posibles significados de la pandemia, un factor psicoide (el virus) que atrae la imaginación ha pasado a primer plano como respuesta al cambio climático. Se observa la sorprendente similitud con la pandemia viral H1N1 ("gripe española"), especialmente en el contexto de un caso que C.G. Jung tuvo en 1919 durante el cual experimentó una serie de visiones y sueños. La imaginería producida puede verse como un intento implícito de "reencantar el mundo" que se encuentra en El Libro Rojo. Por último, se plantea una reconsideración de la pedagogía en respuesta a la pandemia, teniendo en cuenta los aspectos arquetípicos de las comunicaciones por Internet.

Implicit States of Connectivity in the Clinical Practice of Jungian Psychoanalysis and Andean Shamanism.

This paper will describe the spiritual states of "oneness" experienced by Andean shamans in relation to oceanic states in early infancy and working with trauma in Jungian analysis. The author's work exploring implicit energetic experience with Andean shamans will be referenced with comparisons made to depth psychology, in both theory and in practice. Definitions of Q'echua terms describing different psychic meditative states that Andean shamans enter into will be provided as Andean medicine people have a much more developed language for conceptualizing these experiences. A clinical vignette will be presented that demonstrates how the spaces of implicit connection that occur between an analyst and analysand in the analytic setting can be a catalyst for healing.

Cet article décrira les états spirituels d'unité dont les chamanes des Andes font l'expérience, en les mettant en lien avec les états océaniques de la petite enfance et le travail avec le traumatisme dans l'analyse Jungienne. Le travail de l'auteur, d'explorer l'expérience énergétique implicite chez les chamanes des Andes, fera référence à des comparaisons avec la psychologie des profondeurs, dans la théorie et dans la pratique. Des définitions de termes Quechua seront fournies pour décrire les différents états psychiques méditatifs dans lesquels entrent les chamanes des Andes, les médecins-chamanes des Andes ayant un langage bien plus développé pour conceptualiser de telles expériences. Une vignette clinique sera donnée pour montrer comment les espaces de connexion implicite qui se produisent entre un analyste et un analysant dans la situation analytique peuvent catalyser les processus de guérison.

El presente trabajo describe los estados espirituales de "unidad" experimentados por shamanes Andinos en relación a los estados oceánicos en la temprana infancia y al trabajo con trauma en el análisis Junguiano. Se hará referencia al trabajo de exploración de experiencias implícitas energéticas de la autora con shamanes Andinos comparándolo con la psicología profunda, tanto en la práctica como en la teoría. Se brindan definiciones de términos Quechuas que describen diferentes estados meditativos a los que acceden los shamanes Andinos, debido a que los seres medicina Andinos poseen un lenguaje más desarrollado para conceptualizar estas experiencias. Se presenta una viñeta clínica que demuestra cómo los espacios de conexión implícita que suceden entre analista y analizando en el contexto analítico puede ser un catalizador para la sanación.

1. Victims of Enforced Disappearances: Absent Bodies, Inner Presences: 1. Victims of Enforced Disappearances: Absent Bodies, Inner Presences1.

Enforced disappearance represents the quintessence of human rights violations with a strong psychological component. Bodies vanishing have a deterrent effect by terrorizing and paralyzing the entire society. However, the absence of those bodies is overly present in the inner experience of the families of the disappeared, who are victims in their turn. A state of severe psychological deterioration affects the relatives of the disappeared: depression, anxiety, powerlessness, guilt, post-traumatic stress disorder, inability to mourn, even suicide are the consequences of the unbearable uncertainty about the fate of the loved one. But the disappeared persons, notwithstanding the absence of their bodies, continue to be more present than ever in the inner experience of those who have loved them. For the families of the disappeared, to regain psychological equilibrium is a fine balance between the need to remember and the necessity to forget. The author affirms that, at a social and political level, to cultivate a collective memory of enforced disappearance is an ethical duty which validates the actual occurrence of the atrocities, helps prevent repetition and alleviates the transgenerational transmission of trauma.

Les disparitions forcées représentent la quintessence des violations des droits humains avec une forte composante psychologique. Les corps que l'on ne retrouve pas sont un moyen de dissuasion qui opère en terrorisant et paralysant la société toute entière. L'absence de ces corps est excessivement présente dans l'expérience intérieure des familles de ces disparus ; elles deviennent des victimes à leur tour. Un état de détérioration psychologique aigu affecte les membres de la famille du disparu : dépression, angoisse, sentiment d'impuissance, culpabilité, syndrome post-traumatique, incapacité à faire le deuil, et même le suicide sont les conséquences de l'insupportable incertitude concernant le destin de la personne aimée. Les personnes disparues, du fait de l'absence de leur dépouille, continuent d'être plus que jamais présentes dans l'expérience intérieure de ceux qui les ont aimées. Pour les familles des disparus, retrouver une stabilité psychologique se trouve dans un équilibre délicat entre le besoin de se souvenir et la nécessité d'oublier. L'auteur soutient qu'au niveau social et politique, cultiver une mémoire collective des disparitions forcées est un devoir éthique qui confirme que des atrocités ont bien eu lieu, qui aide à en prévenir la répétition et qui allège la transmission transgénérationnelle du traumatisme.

La desaparición forzada representa la quintaesencia de las violaciones de derechos humanos con un fuerte componente psicológico. La desaparición de cuerpos tiene un efecto disuasorio al aterrorizar y paralizar a toda la sociedad. Sin embargo, la ausencia de esos cuerpos está excesivamente presente en la experiencia interior de las familias de los desaparecidos, que son víctimas a su vez. Un estado de grave deterioro psicológico afecta a los familiares de los desaparecidos: depresión, ansiedad, impotencia, culpabilidad, trastorno de estrés postraumático, incapacidad para el duelo, incluso suicidio son las consecuencias de la insoportable incertidumbre sobre la suerte del ser querido. Pero las personas desaparecidas, a pesar de la ausencia de sus cuerpos, siguen estando más presentes que nunca en la experiencia interior de quienes las han amado. Para las familias de los desaparecidos, recuperar el equilibrio psicológico es un delicado equilibrio entre la necesidad de recordar y la necesidad de olvidar. La autora afirma que, a nivel social y político, cultivar una memoria colectiva de la desaparición forzada es un deber ético que valida la ocurrencia real de las atrocidades, ayuda a prevenir su repetición y alivia la transmisión transgeneracional del trauma.

Linking oxytocin and arginine vasopressin signaling abnormalities to social behavior impairments in Prader-Willi syndrome.

Prader-Willi syndrome (PWS) is a genetic neurodevelopmental disorder. Global hypothalamic dysfunction is a core feature of PWS and has been implicated as a driver of many of PWS's phenotypic characteristics (e.g., hyperphagia-induced obesity, hypogonadism, short stature). Although the two neuropeptides (i.e., oxytocin [OXT] and arginine vasopressin [AVP]) most implicated in mammalian prosocial functioning are of hypothalamic origin, and social functioning is markedly impaired in PWS, there has been little consideration of how dysregulation of these neuropeptide signaling pathways may contribute to PWS's social behavior impairments. The present article addresses this gap in knowledge by providing a comprehensive review of the preclinical and clinical PWS literature-spanning endogenous neuropeptide measurement to exogenous neuropeptide administration studies-to better understand the roles of OXT and AVP signaling in this population. The preponderance of evidence indicates that OXT and AVP signaling are indeed dysregulated in PWS, and that these neuropeptide pathways may provide promising targets for therapeutic intervention in a patient population that currently lacks a pharmacological strategy for its debilitating social behavior symptoms.

Perspectivism and shamanism in the Jungian clinic: the jaguar as an archetypal image of the Latin American cultural unconscious.

Amerindians, living in a perspective of synchronicity, attribute to symmetry a negative value that produces an understanding of unstable dualism cosmologies, in a continuous and dynamic imbalance, in a notion of complementarity between conscious and unconscious. These notions are in line with the view of synchronicity proposed by Jung (1952/1972) and Cambray (2013), a view that expands temporal, acausal boundaries, within a perspective of interconnection, resonance and correspondence. Amerindian epistemologies break-up the discontinuity between animals and humans. By establishing a parallel with the Jungian concept of the relationship between unconscious and conscious, we reach a dimension of personification of both, a continuous and permanent flow of meaning. We introduce the jaguar as a symbol of Amerindian cultures and as an archetypal image of the numinosum that activates the unconscious, in asymmetrical and symmetrical movements. This is a qualitative contribution of indigenous mythologies to the understanding of the relationship between unconscious and conscious. Through perspectivism and Amerindian shamanism, we reflect on the archetypal image of the jaguar, as a mythological Latin American knowledge, which contributes to an understanding of the human being in the world, in an instinctive and spiritual integration. Recognizing this cosmos expands the ability to observe and access another point of view, in which the human being is seen in the jaguar, a personification or psychification of his unconscious. In clinical practice, it means finding the humanity that was left behind by that human who became an animal. The shaman, as a therapist, takes on the role of an active interlocutor in the exchange of human and non-human subjectivities, in an amplification process.

Les Amérindiens, vivants dans une perspective de synchronicité, attribuent à la symétrie une valeur négative, qui produit une compréhension des cosmologies du dualisme instable, dans un déséquilibre continu et dynamique, avec la notion de complémentarité entre conscient et inconscient. Ces notions sont en cohérence avec la vision de synchronicité proposée par Jung (1952/1972) et Cambray (2013), une vision qui élargit les frontières temporelles et acausales, dans une perspective d'interconnexion, de résonnance et de correspondance. Les épistémologies amérindiennes cassent la discontinuité entre les animaux et les humains. En établissant un parallèle avec le concept de relation entre inconscient et conscient, nous atteignons la dimension de personnification des deux, un flux permanent de sens. Nous introduisons le jaguar en tant que symbole des cultures amérindiennes et image archétypale du numineux qui active l'inconscient, dans des mouvements asymétriques et symétriques. Il s'agit là d'une contribution qualitative des mythologies indigènes à la compréhension de la relation entre inconscient et conscient. A travers le perspectivisme et le chamanisme amérindien, nous réfléchissons à l'image archétypale du jaguar, en tant que savoir mythologique Amérindien, qui contribue à la compréhension de l'être humain dans le monde, dans une intégration instinctive et spirituelle. Reconnaitre ce cosmos élargit notre capacité à observer et à avoir accès à un autre point de vue, dans lequel l'être humain est vu dans le jaguar, une personnification ou psychification de son inconscient. Dans la pratique clinique, cela signifie de trouver l'humanité qui a été abandonnée par l'humain qui est devenu animal. Le chamane, en tant que thérapeute, prend le rôle d'un interlocuteur actif dans l'échange de subjectivités humaines et non-humaines, dans un processus d'amplification.

Los indios americanos, habitando en una perspectiva de sincronicidad, atribuyen a la simetría un valor negativo dando lugar a una comprensión sobre las cosmologías de un dualismo inestable, en un desbalance continuo y dinámico, y en una noción de complementariedad entre consciente e inconsciente. Estas nociones son similares con la mirada sobre sincronicidad propuesta por Jung (1952/1972) y por Cambray (2013), una mirada que expande las fronteras temporales, acausales, dentro de una perspectiva de interconexión, resonancia y correspondencia. Las epistemologías amerindias rompen con la discontinuidad entre animales y humanos. Al establecer un paralelismo con el concepto Junguiano de la relación entre inconsciente y consciente, alcanzamos una dimensión en la cual se personifica a ambos, en un constante y permanente fluir de sentidos. Introducimos el yaguar como símbolo de las culturas amerindias y como imagen arquetípica de lo numinoso que se activa en el inconsciente, en movimientos asimétricos y simétricos. Es una contribución cualitativa de las mitologías indígenas a la comprensión de la relación entre inconsciente y consciente. A través del perspectivismo y del shamanismo amerindio, nos proponemos reflexionar sobre la imagen arquetípica del yaguar, como conocimiento mitológico latinoamericano, el cual contribuye a una comprensión del ser humano en el mundo, en una integración instintiva y espiritual. Reconocer este cosmos expande la habilidad para observar y acceder a otro punto de vista, en el que el ser humano es visto en el yaguar, como una personificación o psiquización de su inconsciente. En la práctica clínica, significa encontrar la humanidad que fue dejada atrás por aquel humano devenido en animal. El/la shaman/a como terapeuta, toma el rol de un interlocutor activo en el intercambio de subjetividades humanas y no-humanas, en un proceso de amplificación.

Os ameríndios, vivendo em uma perspectiva de sincronicidade, atribuem à simetria um valor negativo que produz uma compreensão das cosmologias instáveis do dualismo, em um desequilíbrio contínuo e dinâmico, em uma noção de complementaridade entre consciente e inconsciente. Essas noções estão de acordo com a visão de sincronicidade proposta por Jung (1952/1972) e Cambray (2013), uma visão que expande as fronteiras temporais e acausais, dentro de uma perspectiva de interconexão, ressonância e correspondência. Epistemologias ameríndias rompem a descontinuidade entre animais e humanos. Estabelecendo um paralelo com o conceito junguiano da relação entre inconsciente e consciente, alcançamos uma dimensão de personificação de ambos, um fluxo contínuo e permanente de significado. Apresentamos a onça-pintada como um símbolo das culturas ameríndias e como uma imagem arquetípica do numinoso que ativa o inconsciente, em movimentos assimétricos e simétricos. Esta é uma contribuição qualitativa das mitologias indígenas para a compreensão da relação entre inconsciente e consciente. Através do perspectivismo e do xamanismo ameríndio, refletimos sobre a imagem arquetípica da onça-pintada, como um conhecimento mitológico latino-americano, que contribui para uma compreensão do ser humano no mundo, em uma integração instintiva e espiritual. Reconhecer esse cosmos expande a capacidade de observar e acessar outro ponto de vista, no qual o ser humano é visto na onça-pintada, uma personificação ou ou psiqueificação de seu inconsciente. Na prática clínica, significa encontrar a humanidade que foi deixada para trás por aquele humano que se tornou um animal. O xamã, como terapeuta, assume o papel de interlocutor ativo na troca de subjetividades humanas e não humanas, em um processo de amplificação.