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1.
Annu Rev Cell Dev Biol ; 37: 495-517, 2021 10 06.
Artículo en Inglés | MEDLINE | ID: mdl-34416113

RESUMEN

With the discovery of the incredible diversity of neurons, Cajal and coworkers laid the foundation of modern neuroscience. Neuron types are not only structural units of nervous systems but also evolutionary units, because their identities are encoded in the genome. With the advent of high-throughput cellular transcriptomics, neuronal identities can be characterized and compared systematically across species. The comparison of neurons in mammals, reptiles, and birds indicates that the mammalian cerebral cortex is a mosaic of deeply conserved and recently evolved neuron types. Using the cerebral cortex as a case study, this review illustrates how comparing neuron types across species is key to reconciling observations on neural development, neuroanatomy, circuit wiring, and physiology for an integrated understanding of brain evolution.


Asunto(s)
Evolución Biológica , Corteza Cerebral , Animales , Encéfalo/fisiología , Corteza Cerebral/anatomía & histología , Mamíferos , Neurogénesis , Neuronas/metabolismo
2.
Annu Rev Neurosci ; 43: 231-247, 2020 07 08.
Artículo en Inglés | MEDLINE | ID: mdl-32084328

RESUMEN

The claustrum is one of the most widely connected regions of the forebrain, yet its function has remained obscure, largely due to the experimentally challenging nature of targeting this small, thin, and elongated brain area. However, recent advances in molecular techniques have enabled the anatomy and physiology of the claustrum to be studied with the spatiotemporal and cell type-specific precision required to eventually converge on what this area does. Here we review early anatomical and electrophysiological results from cats and primates, as well as recent work in the rodent, identifying the connectivity, cell types, and physiological circuit mechanisms underlying the communication between the claustrum and the cortex. The emerging picture is one in which the rodent claustrum is closely tied to frontal/limbic regions and plays a role in processes, such as attention, that are associated with these areas.


Asunto(s)
Ganglios Basales/fisiología , Corteza Cerebral/anatomía & histología , Corteza Cerebral/fisiología , Claustro/anatomía & histología , Vías Nerviosas/fisiología , Animales , Ganglios Basales/anatomía & histología , Claustro/fisiopatología , Lóbulo Frontal/anatomía & histología , Lóbulo Frontal/fisiología , Corteza Prefrontal/anatomía & histología , Corteza Prefrontal/fisiología
3.
Physiol Rev ; 100(3): 1181-1228, 2020 07 01.
Artículo en Inglés | MEDLINE | ID: mdl-32078778

RESUMEN

For more than one century, brain processing was mainly thought in a localizationist framework, in which one given function was underpinned by a discrete, isolated cortical area, and with a similar cerebral organization across individuals. However, advances in brain mapping techniques in humans have provided new insights into the organizational principles of anatomo-functional architecture. Here, we review recent findings gained from neuroimaging, electrophysiological, as well as lesion studies. Based on these recent data on brain connectome, we challenge the traditional, outdated localizationist view and propose an alternative meta-networking theory. This model holds that complex cognitions and behaviors arise from the spatiotemporal integration of distributed but relatively specialized networks underlying conation and cognition (e.g., language, spatial cognition). Dynamic interactions between such circuits result in a perpetual succession of new equilibrium states, opening the door to considerable interindividual behavioral variability and to neuroplastic phenomena. Indeed, a meta-networking organization underlies the uniquely human propensity to learn complex abilities, and also explains how postlesional reshaping can lead to some degrees of functional compensation in brain-damaged patients. We discuss the major implications of this approach in fundamental neurosciences as well as for clinical developments, especially in neurology, psychiatry, neurorehabilitation, and restorative neurosurgery.


Asunto(s)
Corteza Cerebral/anatomía & histología , Corteza Cerebral/fisiología , Red Nerviosa , Conectoma/métodos , Humanos , Vías Nerviosas/fisiología , Plasticidad Neuronal/fisiología
4.
Nat Methods ; 21(9): 1736-1742, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39014074

RESUMEN

Neuroimaging data analysis relies on normalization to standard anatomical templates to resolve macroanatomical differences across brains. Existing human cortical surface templates sample locations unevenly because of distortions introduced by inflation of the folded cortex into a standard shape. Here we present the onavg template, which affords uniform sampling of the cortex. We created the onavg template based on openly available high-quality structural scans of 1,031 brains-25 times more than existing cortical templates. We optimized the vertex locations based on cortical anatomy, achieving an even distribution. We observed consistently higher multivariate pattern classification accuracies and representational geometry inter-participant correlations based on onavg than on other templates, and onavg only needs three-quarters as much data to achieve the same performance compared with other templates. The optimized sampling also reduces CPU time across algorithms by 1.3-22.4% due to less variation in the number of vertices in each searchlight.


Asunto(s)
Algoritmos , Corteza Cerebral , Humanos , Corteza Cerebral/diagnóstico por imagen , Corteza Cerebral/anatomía & histología , Neuroimagen/métodos , Imagen por Resonancia Magnética/métodos , Procesamiento de Imagen Asistido por Computador/métodos , Neurociencias/métodos , Mapeo Encefálico/métodos , Masculino , Femenino
5.
Nature ; 598(7879): 188-194, 2021 10.
Artículo en Inglés | MEDLINE | ID: mdl-34616074

RESUMEN

The cortico-basal ganglia-thalamo-cortical loop is one of the fundamental network motifs in the brain. Revealing its structural and functional organization is critical to understanding cognition, sensorimotor behaviour, and the natural history of many neurological and neuropsychiatric disorders. Classically, this network is conceptualized to contain three information channels: motor, limbic and associative1-4. Yet this three-channel view cannot explain the myriad functions of the basal ganglia. We previously subdivided the dorsal striatum into 29 functional domains on the basis of the topography of inputs from the entire cortex5. Here we map the multi-synaptic output pathways of these striatal domains through the globus pallidus external part (GPe), substantia nigra reticular part (SNr), thalamic nuclei and cortex. Accordingly, we identify 14 SNr and 36 GPe domains and a direct cortico-SNr projection. The striatonigral direct pathway displays a greater convergence of striatal inputs than the more parallel striatopallidal indirect pathway, although direct and indirect pathways originating from the same striatal domain ultimately converge onto the same postsynaptic SNr neurons. Following the SNr outputs, we delineate six domains in the parafascicular and ventromedial thalamic nuclei. Subsequently, we identify six parallel cortico-basal ganglia-thalamic subnetworks that sequentially transduce specific subsets of cortical information through every elemental node of the cortico-basal ganglia-thalamic loop. Thalamic domains relay this output back to the originating corticostriatal neurons of each subnetwork in a bona fide closed loop.


Asunto(s)
Ganglios Basales/citología , Corteza Cerebral/citología , Vías Nerviosas , Neuronas/citología , Tálamo/citología , Animales , Ganglios Basales/anatomía & histología , Corteza Cerebral/anatomía & histología , Masculino , Ratones , Ratones Endogámicos C57BL , Tálamo/anatomía & histología
6.
Nature ; 600(7888): 274-278, 2021 12.
Artículo en Inglés | MEDLINE | ID: mdl-34759318

RESUMEN

The biophysical properties of neurons are the foundation for computation in the brain. Neuronal size is a key determinant of single neuron input-output features and varies substantially across species1-3. However, it is unknown whether different species adapt neuronal properties to conserve how single neurons process information4-7. Here we characterize layer 5 cortical pyramidal neurons across 10 mammalian species to identify the allometric relationships that govern how neuronal biophysics change with cell size. In 9 of the 10 species, we observe conserved rules that control the conductance of voltage-gated potassium and HCN channels. Species with larger neurons, and therefore a decreased surface-to-volume ratio, exhibit higher membrane ionic conductances. This relationship produces a conserved conductance per unit brain volume. These size-dependent rules result in large but predictable changes in somatic and dendritic integrative properties. Human neurons do not follow these allometric relationships, exhibiting much lower voltage-gated potassium and HCN conductances. Together, our results in layer 5 neurons identify conserved evolutionary principles for neuronal biophysics in mammals as well as notable features of the human cortex.


Asunto(s)
Biofisica , Tamaño de la Célula , Corteza Cerebral/citología , Mamíferos , Células Piramidales/citología , Células Piramidales/fisiología , Animales , Corteza Cerebral/anatomía & histología , Corteza Cerebral/fisiología , Dendritas/fisiología , Conductividad Eléctrica , Humanos , Canales Regulados por Nucleótidos Cíclicos Activados por Hiperpolarización/metabolismo , Masculino , Canales de Potasio con Entrada de Voltaje/metabolismo , Especificidad de la Especie
7.
Nature ; 599(7886): 640-644, 2021 11.
Artículo en Inglés | MEDLINE | ID: mdl-34707291

RESUMEN

The cognitive abilities that characterize humans are thought to emerge from unique features of the cortical circuit architecture of the human brain, which include increased cortico-cortical connectivity. However, the evolutionary origin of these changes in connectivity and how they affected cortical circuit function and behaviour are currently unknown. The human-specific gene duplication SRGAP2C emerged in the ancestral genome of the Homo lineage before the major phase of increase in brain size1,2. SRGAP2C expression in mice increases the density of excitatory and inhibitory synapses received by layer 2/3 pyramidal neurons (PNs)3-5. Here we show that the increased number of excitatory synapses received by layer 2/3 PNs induced by SRGAP2C expression originates from a specific increase in local and long-range cortico-cortical connections. Mice humanized for SRGAP2C expression in all cortical PNs displayed a shift in the fraction of layer 2/3 PNs activated by sensory stimulation and an enhanced ability to learn a cortex-dependent sensory-discrimination task. Computational modelling revealed that the increased layer 4 to layer 2/3 connectivity induced by SRGAP2C expression explains some of the key changes in sensory coding properties. These results suggest that the emergence of SRGAP2C at the birth of the Homo lineage contributed to the evolution of specific structural and functional features of cortical circuits in the human cortex.


Asunto(s)
Corteza Cerebral , Vías Nerviosas , Animales , Femenino , Humanos , Masculino , Ratones , Señalización del Calcio , Corteza Cerebral/anatomía & histología , Corteza Cerebral/citología , Corteza Cerebral/fisiología , Discriminación en Psicología , Ratones Transgénicos , Vías Nerviosas/fisiología , Tamaño de los Órganos , Células Piramidales/fisiología , Sinapsis/metabolismo
8.
Annu Rev Neurosci ; 41: 163-183, 2018 07 08.
Artículo en Inglés | MEDLINE | ID: mdl-29618284

RESUMEN

The thalamus has long been suspected to have an important role in cognition, yet recent theories have favored a more corticocentric view. According to this view, the thalamus is an excitatory feedforward relay to or between cortical regions, and cognitively relevant computations are exclusively cortical. Here, we review anatomical, physiological, and behavioral studies along evolutionary and theoretical dimensions, arguing for essential and unique thalamic computations in cognition. Considering their architectural features as well as their ability to initiate, sustain, and switch cortical activity, thalamic circuits appear uniquely suited for computing contextual signals that rapidly reconfigure task-relevant cortical representations. We introduce a framework that formalizes this notion, show its consistency with several findings, and discuss its prediction of thalamic roles in perceptual inference and behavioral flexibility. Overall, our framework emphasizes an expanded view of the thalamus in cognitive computations and provides a roadmap to test several of its theoretical and experimental predictions.


Asunto(s)
Corteza Cerebral/fisiología , Cognición/fisiología , Modelos Neurológicos , Vías Nerviosas/fisiología , Tálamo/fisiología , Animales , Corteza Cerebral/anatomía & histología , Simulación por Computador , Humanos , Vías Nerviosas/anatomía & histología , Tálamo/anatomía & histología
9.
Proc Natl Acad Sci U S A ; 120(11): e2214834120, 2023 03 14.
Artículo en Inglés | MEDLINE | ID: mdl-36893272

RESUMEN

Human cortical expansion has occurred non-uniformly across the brain. We assessed the genetic architecture of cortical global expansion and regionalization by comparing two sets of genome-wide association studies of 24 cortical regions with and without adjustment for global measures (i.e., total surface area, mean cortical thickness) using a genetically informed parcellation in 32,488 adults. We found 393 and 756 significant loci with and without adjusting for globals, respectively, where 8% and 45% loci were associated with more than one region. Results from analyses without adjustment for globals recovered loci associated with global measures. Genetic factors that contribute to total surface area of the cortex particularly expand anterior/frontal regions, whereas those contributing to thicker cortex predominantly increase dorsal/frontal-parietal thickness. Interactome-based analyses revealed significant genetic overlap of global and dorsolateral prefrontal modules, enriched for neurodevelopmental and immune system pathways. Consideration of global measures is important in understanding the genetic variants underlying cortical morphology.


Asunto(s)
Estudio de Asociación del Genoma Completo , Imagen por Resonancia Magnética , Adulto , Humanos , Corteza Cerebral/anatomía & histología , Corteza Prefrontal , Encéfalo
10.
J Neurosci ; 44(24)2024 Jun 12.
Artículo en Inglés | MEDLINE | ID: mdl-38866538

RESUMEN

In 1998, Jones suggested a classification of thalamocortical projections into core and matrix divisions (Jones, 1998). In this classification, core projections are specific, topographical, innervate middle cortical layers, and serve to transmit specific information to the cortex for further analysis; matrix projections, in contrast, are diffuse, much less topographic, innervate upper layers, especially Layer 1, and serve a more global, modulatory function, such as affecting levels of arousal. This classification has proven especially influential in studies of thalamocortical relationships. Whereas it may be the case that a clear subset of thalamocortical connections fit the core motif, since they are specific, topographic, and innervate middle layers, we argue that there is no clear evidence for any single class that encompasses the remainder of thalamocortical connections as is claimed for matrix. Instead, there is great morphological variation in connections made by thalamocortical projections fitting neither a core nor matrix classification. We thus conclude that the core/matrix classification should be abandoned, because its application is not helpful in providing insights into thalamocortical interactions and can even be misleading. As one example of the latter, recent suggestions indicate that core projections are equivalent to first-order thalamic relays (i.e., those that relay subcortical information to the cortex) and matrix to higher-order relays (i.e., those that relay information from one cortical area to another), but available evidence does not support this relationship. All of this points to a need to replace the core/matrix grouping with a more complete classification of thalamocortical projections.


Asunto(s)
Corteza Cerebral , Vías Nerviosas , Tálamo , Tálamo/fisiología , Tálamo/anatomía & histología , Corteza Cerebral/fisiología , Corteza Cerebral/anatomía & histología , Humanos , Animales , Vías Nerviosas/fisiología , Vías Nerviosas/anatomía & histología
11.
Nature ; 575(7781): 195-202, 2019 11.
Artículo en Inglés | MEDLINE | ID: mdl-31666704

RESUMEN

The mammalian cortex is a laminar structure containing many areas and cell types that are densely interconnected in complex ways, and for which generalizable principles of organization remain mostly unknown. Here we describe a major expansion of the Allen Mouse Brain Connectivity Atlas resource1, involving around a thousand new tracer experiments in the cortex and its main satellite structure, the thalamus. We used Cre driver lines (mice expressing Cre recombinase) to comprehensively and selectively label brain-wide connections by layer and class of projection neuron. Through observations of axon termination patterns, we have derived a set of generalized anatomical rules to describe corticocortical, thalamocortical and corticothalamic projections. We have built a model to assign connection patterns between areas as either feedforward or feedback, and generated testable predictions of hierarchical positions for individual cortical and thalamic areas and for cortical network modules. Our results show that cell-class-specific connections are organized in a shallow hierarchy within the mouse corticothalamic network.


Asunto(s)
Corteza Cerebral/anatomía & histología , Corteza Cerebral/citología , Vías Nerviosas/anatomía & histología , Vías Nerviosas/citología , Tálamo/anatomía & histología , Tálamo/citología , Animales , Axones/fisiología , Corteza Cerebral/fisiología , Femenino , Integrasas/genética , Integrasas/metabolismo , Masculino , Ratones , Ratones Endogámicos C57BL , Vías Nerviosas/fisiología , Tálamo/fisiología
12.
Cereb Cortex ; 34(6)2024 Jun 04.
Artículo en Inglés | MEDLINE | ID: mdl-38850213

RESUMEN

The relative contributions of genetic variation and experience in shaping the morphology of the adolescent brain are not fully understood. Using longitudinal data from 11,665 subjects in the ABCD Study, we fit vertex-wise variance components including family effects, genetic effects, and subject-level effects using a computationally efficient framework. Variance in cortical thickness and surface area is largely attributable to genetic influence, whereas sulcal depth is primarily explained by subject-level effects. Our results identify areas with heterogeneous distributions of heritability estimates that have not been seen in previous work using data from cortical regions. We discuss the biological importance of subject-specific variance and its implications for environmental influences on cortical development and maturation.


Asunto(s)
Corteza Cerebral , Imagen por Resonancia Magnética , Humanos , Corteza Cerebral/crecimiento & desarrollo , Corteza Cerebral/anatomía & histología , Corteza Cerebral/diagnóstico por imagen , Masculino , Femenino , Adolescente , Estudios Longitudinales , Interacción Gen-Ambiente , Niño , Ambiente
13.
Cereb Cortex ; 34(7)2024 Jul 03.
Artículo en Inglés | MEDLINE | ID: mdl-39077916

RESUMEN

The lifetime effects of repetitive head impacts have captured considerable public and scientific interest over the past decade, yet a knowledge gap persists in our understanding of midlife neurological well-being, particularly in amateur level athletes. This study aimed to identify the effects of lifetime exposure to sports-related head impacts on brain morphology in retired, amateur athletes. This cross-sectional study comprised of 37 former amateur contact sports athletes and 21 age- and sex-matched noncontact athletes. High-resolution anatomical, T1 scans were analyzed for the cortical morphology, including cortical thickness, sulcal depth, and sulcal curvature, and cognitive function was assessed using the Dementia Rating Scale-2. Despite no group differences in cognitive functions, the contact group exhibited significant cortical thinning particularly in the bilateral frontotemporal regions and medial brain regions, such as the cingulate cortex and precuneus, compared to the noncontact group. Deepened sulcal depth and increased sulcal curvature across all four lobes of the brain were also notable in the contact group. These data suggest that brain morphology of middle-aged former amateur contact athletes differs from that of noncontact athletes and that lifetime exposure to repetitive head impacts may be associated with neuroanatomical changes.


Asunto(s)
Atletas , Corteza Cerebral , Imagen por Resonancia Magnética , Humanos , Masculino , Femenino , Corteza Cerebral/diagnóstico por imagen , Corteza Cerebral/patología , Corteza Cerebral/anatomía & histología , Estudios Transversales , Persona de Mediana Edad , Traumatismos en Atletas/patología , Traumatismos en Atletas/diagnóstico por imagen , Anciano , Conmoción Encefálica/patología , Conmoción Encefálica/diagnóstico por imagen , Cognición/fisiología
14.
Annu Rev Cell Dev Biol ; 27: 653-79, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21801012

RESUMEN

Cerebral cortical progenitor cells can be classified into several different types, and each progenitor type integrates cell-intrinsic and cell-extrinsic cues to regulate neurogenesis. On one hand, cell-intrinsic mechanisms that depend upon appropriate apical-basal polarity are established by adherens junctions and apical complex proteins and are particularly important in progenitors with apical processes contacting the lateral ventricle. The apical protein complexes themselves are concentrated at the ventricular surface, and apical complex proteins regulate mitotic spindle orientation and cell fate. On the other hand, remarkably little is known about how cell-extrinsic cues signal to progenitors and couple with cell-intrinsic mechanisms to instruct neurogenesis. Recent research shows that the cerebrospinal fluid, which contacts apical progenitors at the ventricular surface and bathes the apical complex of these cells, provides growth- and survival-promoting cues for neural progenitor cells in developing and adult brain. This review addresses how the apical-basal polarity of progenitor cells regulates cell fate and allows progenitors to sample diffusible signals distributed by the cerebrospinal fluid. We also review several classes of signaling factors that the cerebrospinal fluid distributes to the developing brain to instruct neurogenesis.


Asunto(s)
Corteza Cerebral/anatomía & histología , Corteza Cerebral/crecimiento & desarrollo , Corteza Cerebral/metabolismo , Líquido Cefalorraquídeo/metabolismo , Neurogénesis/fisiología , Uniones Adherentes/metabolismo , Animales , Diferenciación Celular/fisiología , Linaje de la Célula , Polaridad Celular , Proliferación Celular , Líquido Cefalorraquídeo/química , Proteínas Hedgehog/metabolismo , Humanos , Péptidos y Proteínas de Señalización Intercelular/metabolismo , Neuronas/citología , Neuronas/fisiología , Receptores Notch/metabolismo , Transducción de Señal/fisiología , Células Madre/citología , Células Madre/fisiología , Tretinoina/metabolismo
15.
Neuroimage ; 297: 120739, 2024 Aug 15.
Artículo en Inglés | MEDLINE | ID: mdl-39009250

RESUMEN

Heritability and genetic covariance/correlation quantify the marginal and shared genetic effects across traits. They offer insights on the genetic architecture of complex traits and diseases. To explore how genetic variations contribute to brain function variations, we estimated heritability and genetic correlation across cortical thickness, surface area, and volume of 33 anatomically predefined regions in left and right hemispheres, using summary statistics of genome-wide association analyses of 31,968 participants in the UK Biobank. To characterize the relationships between these regions of interest, we constructed a genetic network for these regions using recursive two-way cut-offs in similarity matrices defined by genetic correlations. The inferred genetic network matches the brain lobe mapping more closely than the network inferred from phenotypic similarities. We further studied the associations between the genetic network for brain regions and 30 complex traits through a novel composite-linkage disequilibrium score regression method. We identified seven significant pairs, which offer insights on the genetic basis for regions of interest mediated by cortical measures.


Asunto(s)
Corteza Cerebral , Estudio de Asociación del Genoma Completo , Humanos , Corteza Cerebral/diagnóstico por imagen , Corteza Cerebral/anatomía & histología , Femenino , Masculino , Imagen por Resonancia Magnética , Persona de Mediana Edad , Redes Reguladoras de Genes/genética , Polimorfismo de Nucleótido Simple , Anciano , Modelos Genéticos
16.
Neuroimage ; 295: 120660, 2024 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-38815676

RESUMEN

The topological organization of the macroscopic cortical networks important for the development of complex brain functions. However, how the cortical morphometric organization develops during the third trimester and whether it demonstrates sexual and individual differences at this particular stage remain unclear. Here, we constructed the morphometric similarity network (MSN) based on morphological and microstructural features derived from multimodal MRI of two independent cohorts (cross-sectional and longitudinal) scanned at 30-44 postmenstrual weeks (PMW). Sex difference and inter-individual variations of the MSN were also examined on these cohorts. The cross-sectional analysis revealed that both network integration and segregation changed in a nonlinear biphasic trajectory, which was supported by the results obtained from longitudinal analysis. The community structure showed remarkable consistency between bilateral hemispheres and maintained stability across PMWs. Connectivity within the primary cortex strengthened faster than that within high-order communities. Compared to females, male neonates showed a significant reduction in the participation coefficient within prefrontal and parietal cortices, while their overall network organization and community architecture remained comparable. Furthermore, by using the morphometric similarity as features, we achieved over 65 % accuracy in identifying an individual at term-equivalent age from images acquired after birth, and vice versa. These findings provide comprehensive insights into the development of morphometric similarity throughout the perinatal cortex, enhancing our understanding of the establishment of neuroanatomical organization during early life.


Asunto(s)
Corteza Cerebral , Imagen por Resonancia Magnética , Caracteres Sexuales , Humanos , Femenino , Masculino , Corteza Cerebral/diagnóstico por imagen , Corteza Cerebral/crecimiento & desarrollo , Corteza Cerebral/anatomía & histología , Recién Nacido , Estudios Transversales , Estudios Longitudinales , Red Nerviosa/diagnóstico por imagen , Red Nerviosa/crecimiento & desarrollo , Red Nerviosa/anatomía & histología , Embarazo
17.
Neuroimage ; 296: 120673, 2024 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-38851550

RESUMEN

Morphological features sourced from structural magnetic resonance imaging can be used to infer human brain connectivity. Although integrating different morphological features may theoretically be beneficial for obtaining more precise morphological connectivity networks (MCNs), the empirical evidence to support this supposition is scarce. Moreover, the incorporation of different morphological features remains an open question. In this study, we proposed a method to construct cortical MCNs based on multiple morphological features. Specifically, we adopted a multi-dimensional kernel density estimation algorithm to fit regional joint probability distributions (PDs) from different combinations of four morphological features, and estimated inter-regional similarity in the joint PDs via Jensen-Shannon divergence. We evaluated the method by comparing the resultant MCNs with those built based on different single morphological features in terms of topological organization, test-retest reliability, biological plausibility, and behavioral and cognitive relevance. We found that, compared to MCNs built based on different single morphological features, MCNs derived from multiple morphological features displayed less segregated, but more integrated network architecture and different hubs, had higher test-retest reliability, encompassed larger proportions of inter-hemispheric edges and edges between brain regions within the same cytoarchitectonic class, and explained more inter-individual variance in behavior and cognition. These findings were largely reproducible when different brain atlases were used for cortical parcellation. Further analysis of macaque MCNs revealed weak, but significant correlations with axonal connectivity from tract-tracing, independent of the number of morphological features. Altogether, this paper proposes a new method for integrating different morphological features, which will be beneficial for constructing MCNs.


Asunto(s)
Corteza Cerebral , Imagen por Resonancia Magnética , Red Nerviosa , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Femenino , Corteza Cerebral/diagnóstico por imagen , Corteza Cerebral/anatomía & histología , Adulto , Red Nerviosa/diagnóstico por imagen , Red Nerviosa/anatomía & histología , Conectoma/métodos , Algoritmos , Adulto Joven , Procesamiento de Imagen Asistido por Computador/métodos , Mapeo Encefálico/métodos
18.
Neuroimage ; 293: 120616, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38697587

RESUMEN

Cortical parcellation plays a pivotal role in elucidating the brain organization. Despite the growing efforts to develop parcellation algorithms using functional magnetic resonance imaging, achieving a balance between intra-individual specificity and inter-individual consistency proves challenging, making the generation of high-quality, subject-consistent cortical parcellations particularly elusive. To solve this problem, our paper proposes a fully automated individual cortical parcellation method based on consensus graph representation learning. The method integrates spectral embedding with low-rank tensor learning into a unified optimization model, which uses group-common connectivity patterns captured by low-rank tensor learning to optimize subjects' functional networks. This not only ensures consistency in brain representations across different subjects but also enhances the quality of each subject's representation matrix by eliminating spurious connections. More importantly, it achieves an adaptive balance between intra-individual specificity and inter-individual consistency during this process. Experiments conducted on a test-retest dataset from the Human Connectome Project (HCP) demonstrate that our method outperforms existing methods in terms of reproducibility, functional homogeneity, and alignment with task activation. Extensive network-based comparisons on the HCP S900 dataset reveal that the functional network derived from our cortical parcellation method exhibits greater capabilities in gender identification and behavior prediction than other approaches.


Asunto(s)
Corteza Cerebral , Conectoma , Imagen por Resonancia Magnética , Humanos , Imagen por Resonancia Magnética/métodos , Conectoma/métodos , Corteza Cerebral/diagnóstico por imagen , Corteza Cerebral/fisiología , Corteza Cerebral/anatomía & histología , Aprendizaje Automático , Femenino , Masculino , Procesamiento de Imagen Asistido por Computador/métodos , Adulto , Algoritmos , Reproducibilidad de los Resultados
19.
J Neurophysiol ; 132(3): 849-869, 2024 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-39052236

RESUMEN

The human cerebellum is increasingly recognized to be involved in nonmotor and higher-order cognitive functions. Yet, its ties with the entire cerebral cortex have not been holistically studied in a whole brain exploration with a unified analytical framework. Here, we characterized dissociable cortical-cerebellar structural covariation patterns based on regional gray matter volume (GMV) across the brain in n = 38,527 UK Biobank participants. Our results invigorate previous observations in that important shares of cortical-cerebellar structural covariation are described as 1) a dissociation between the higher-level cognitive system and lower-level sensorimotor system and 2) an anticorrelation between the visual-attention system and advanced associative networks within the cerebellum. We also discovered a novel pattern of ipsilateral, rather than contralateral, cerebral-cerebellar associations. Furthermore, phenome-wide association assays revealed key phenotypes, including cognitive phenotypes, lifestyle, physical properties, and blood assays, associated with each decomposed covariation pattern, helping to understand their real-world implications. This systems neuroscience view paves the way for future studies to explore the implications of these structural covariations, potentially illuminating new pathways in our understanding of neurological and cognitive disorders.NEW & NOTEWORTHY Cerebellum's association with the entire cerebral cortex has not been holistically studied in a unified way. Here, we conjointly characterize the population-level cortical-cerebellar structural covariation patterns leveraging ∼40,000 UK Biobank participants whole brain structural scans and ∼1,000 phenotypes. We revitalize the previous hypothesis of an anticorrelation between the visual-attention system and advanced associative networks within the cerebellum. We also discovered a novel ipsilateral cerebral-cerebellar associations. Phenome-wide association (PheWAS) revealed real-world implications of the structural covariation patterns.


Asunto(s)
Cerebelo , Neocórtex , Humanos , Masculino , Femenino , Cerebelo/fisiología , Cerebelo/anatomía & histología , Cerebelo/diagnóstico por imagen , Persona de Mediana Edad , Neocórtex/fisiología , Neocórtex/anatomía & histología , Anciano , Imagen por Resonancia Magnética , Sustancia Gris/anatomía & histología , Sustancia Gris/fisiología , Sustancia Gris/diagnóstico por imagen , Corteza Cerebral/fisiología , Corteza Cerebral/anatomía & histología , Corteza Cerebral/diagnóstico por imagen , Vías Nerviosas/fisiología , Vías Nerviosas/anatomía & histología , Adulto
20.
Hum Brain Mapp ; 45(2): e26565, 2024 Feb 01.
Artículo en Inglés | MEDLINE | ID: mdl-38339954

RESUMEN

This work illustrates the use of normative models in a longitudinal neuroimaging study of children aged 6-17 years and demonstrates how such models can be used to make meaningful comparisons in longitudinal studies, even when individuals are scanned with different scanners across successive study waves. More specifically, we first estimated a large-scale reference normative model using Hierarchical Bayesian Regression from N = 42,993 individuals across the lifespan and from dozens of sites. We then transfer these models to a longitudinal developmental cohort (N = 6285) with three measurement waves acquired on two different scanners that were unseen during estimation of the reference models. We show that the use of normative models provides individual deviation scores that are independent of scanner effects and efficiently accommodate inter-site variations. Moreover, we provide empirical evidence to guide the optimization of sample size for the transfer of prior knowledge about the distribution of regional cortical thicknesses. We show that a transfer set containing as few as 25 samples per site can lead to good performance metrics on the test set. Finally, we demonstrate the clinical utility of this approach by showing that deviation scores obtained from the transferred normative models are able to detect and chart morphological heterogeneity in individuals born preterm.


Asunto(s)
Corteza Cerebral , Imagen por Resonancia Magnética , Niño , Recién Nacido , Humanos , Imagen por Resonancia Magnética/métodos , Teorema de Bayes , Corteza Cerebral/diagnóstico por imagen , Corteza Cerebral/anatomía & histología , Neuroimagen/métodos , Aprendizaje Automático , Encéfalo/diagnóstico por imagen
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