Crotoxin Novel activities for a classic â-neurotoxin
Toxicon
; 55(6): 1045-1060, Jan 28, 2010.
Article
in En
| SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO
| ID: biblio-1068250
Responsible library:
BR78.1
Localization: BR78.1
ABSTRACT
Crotoxin, the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, was the first snake venom protein to be purified and crystallized. Crotoxin is a heterodimericb-neurotoxin that consists of a weakly toxic basic phospholipase A2 and a nonenzymatic, non-toxic acidic component (crotapotin). The classic biological activities normally attributed to crotoxin include neurotoxicity, myotoxicity, nephrotoxicity andcardiotoxicity. However, numerous studies in recent years have shown that crotoxin also has immunomodulatory, anti-inflammatory, anti-microbial, anti-tumor and analgesic actions. In this review, we describe the historical background to the discovery of crotoxinand its main toxic activities and then discuss recent structurefunction studies and investigations that have led to the identification of novel pharmacological activities for the toxin.
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Collection:
06-national
/
BR
Database:
SES-SP
/
SESSP-IBACERVO
/
SESSP-IBPROD
Main subject:
Snake Venoms
/
Crotalus cascavella
/
Crotoxin
Type of study:
Prognostic_studies
Language:
En
Journal:
Toxicon
Year:
2010
Type:
Article