A descriptive and prospective study of 25 patients with Guillain-Barré syndrome, assisted in the Teaching Southern ChildrenHospital in Santiago de Cuba was carried out from January, 2006 to December, 2012, with the aim of identifying their clinical and epidemiological characteristics and to determine the usefulness of the treatment applied. Children younger than 5 years (40.0 percent), malesex and previous upper respiratory infection (both with 60.0 percent), as well as the muscular weakness and osteotendinous areflexia (76.0 percent in each case) prevailed. The inflammatory and acute desmyelinating polyrradiculoneuropathy was the most frequent clinical variant (72.0 percent). Either the treatment with intravenous humanimmunoglobulin as rehabilitation were beneficial and the mortality was low (4.0 percent)(AU)