Molecular biology and clinical implication of hepatitis C virus
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;37(5): 691-695, May 2004. ilus
Article
in En
| LILACS
| ID: lil-357556
Responsible library:
BR1.1
RESUMO
Hepatitis C virus (HCV) was first described in 1989 as the putative viral agent of non-A non-B hepatitis. It is a member of the Flaviviridae family and has been recognized as the major causative agent of chronic liver disease, including chronic active hepatitis, cirrhosis and hepatocellular carcinoma. HCV is a positive RNA virus with a genome containing approximately 9500 nucleotides. It has an open reading frame that encodes a large polyprotein of about 3000 amino acids and is characterized by extensive genetic diversity. HCV has been classified into at least 6 major genotypes with many subtypes and circulates within an infected individual as a number of closely related but distinct variants known as quasispecies. This article reviews aspects of the molecular biology of HCV and their clinical implication.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Genome, Viral
/
3' Untranslated Regions
/
Genotype
Limits:
Humans
Language:
En
Journal:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
2004
Type:
Article
Affiliation country:
Brazil
/
United States