Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.

Finzi, D; Blankson, J; Siliciano, J D; Margolick, J B; Chadwick, K; Pierson, T; Smith, K; Lisziewicz, J; Lori, F; Flexner, C; Quinn, T C; Chaisson, R E; Rosenberg, E; Walker, B; Gange, S; Gallant, J; Siliciano, R F

Finzi, D; Blankson, J; Siliciano, J D; Margolick, J B; Chadwick, K; Pierson, T; Smith, K; Lisziewicz, J; Lori, F; Flexner, C; Quinn, T C; Chaisson, R E; Rosenberg, E; Walker, B; Gange, S; Gallant, J; Siliciano, R F.

Affiliation

Finzi D; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Nat Med ; 5(5): 512-7, 1999 May.

Article in En | MEDLINE | ID: mdl-10229227

Subject(s)

CD4-Positive T-Lymphocytes/virology; HIV Infections/drug therapy; HIV Infections/virology; HIV-1/growth & development; Virus Latency; Adult; CD4-Positive T-Lymphocytes/cytology; Cells, Cultured; Cross-Sectional Studies; Drug Therapy, Combination; Female; HIV Infections/blood; Half-Life; Humans; Longitudinal Studies; Male; Middle Aged; RNA, Viral/blood; Viral Load; Virus Replication

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Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / HIV Infections / HIV-1 / Virus Latency Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 1999 Type: Article Affiliation country: United States

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