X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.

Pavlovsky, A G; Williams, M G; Ye, Q Z; Ortwine, D F; Purchase, C F; White, A D; Dhanaraj, V; Roth, B D; Johnson, L L; Hupe, D; Humblet, C; Blundell, T L

Pavlovsky, A G; Williams, M G; Ye, Q Z; Ortwine, D F; Purchase, C F; White, A D; Dhanaraj, V; Roth, B D; Johnson, L L; Hupe, D; Humblet, C; Blundell, T L.

Affiliation

Pavlovsky AG; Department of Chemistry, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105, USA. Alexander.Pavlovsky@wl.com

Protein Sci ; 8(7): 1455-62, 1999 Jul.

Article in En | MEDLINE | ID: mdl-10422833

Subject(s)

Matrix Metalloproteinase 3/chemistry; Protease Inhibitors/chemistry; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Humans; Matrix Metalloproteinase 3/metabolism; Matrix Metalloproteinase Inhibitors; Models, Molecular; Protease Inhibitors/metabolism; Protein Binding

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Matrix Metalloproteinase 3 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Protein Sci Journal subject: BIOQUIMICA Year: 1999 Type: Article Affiliation country: United States

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