An expanded peripheral T cell population to a cytotoxic T lymphocyte (CTL)-defined, melanocyte-specific antigen in metastatic melanoma patients impacts on generation of peptide-specific CTLs but does not overcome tumor escape from immune surveillance in metastatic lesions.

Anichini, A; Molla, A; Mortarini, R; Tragni, G; Bersani, I; Di Nicola, M; Gianni, A M; Pilotti, S; Dunbar, R; Cerundolo, V; Parmiani, G

Anichini, A; Molla, A; Mortarini, R; Tragni, G; Bersani, I; Di Nicola, M; Gianni, A M; Pilotti, S; Dunbar, R; Cerundolo, V; Parmiani, G.

Affiliation

Anichini A; Department of Experimental Oncology Human Tumor Immunobiology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy. Anichini@istitutotumori.mi.it

J Exp Med ; 190(5): 651-67, 1999 Sep 06.

Article in En | MEDLINE | ID: mdl-10477550

Subject(s)

Antigens, Neoplasm/immunology; Melanocytes/immunology; Melanoma/immunology; Melanoma/secondary; T-Lymphocytes, Cytotoxic/immunology; T-Lymphocytes/immunology; Adult; Aged; Amino Acid Sequence; Antigen-Presenting Cells/immunology; Antigens, Neoplasm/genetics; Female; HLA Antigens/immunology; Humans; Immunohistochemistry; Immunologic Memory; Immunologic Surveillance; Lymphocyte Activation; MART-1 Antigen; Male; Middle Aged; Monophenol Monooxygenase/immunology; Neoplasm Proteins/genetics; Neoplasm Proteins/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / T-Lymphocytes, Cytotoxic / Melanocytes / Melanoma / Antigens, Neoplasm Type of study: Screening_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Exp Med Year: 1999 Type: Article Affiliation country: Italy

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