Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease.

Costagliola, S; Many, M C; Denef, J F; Pohlenz, J; Refetoff, S; Vassart, G

Costagliola, S; Many, M C; Denef, J F; Pohlenz, J; Refetoff, S; Vassart, G.

Affiliation

Costagliola S; Institut de Recherche en Biologie Humaine et Nucléaire (IRIBHN), Faculté de Médecine, University of Brussels, B-1070 Brussels, Belgium.

J Clin Invest ; 105(6): 803-11, 2000 Mar.

Article in En | MEDLINE | ID: mdl-10727449

Subject(s)

Autoantibodies/biosynthesis; Autoimmune Diseases/immunology; Disease Models, Animal; Graves Disease/immunology; Receptors, Thyrotropin/biosynthesis; Receptors, Thyrotropin/immunology; Animals; Autoimmune Diseases/etiology; CHO Cells; Cricetinae; Cricetulus; DNA, Complementary/adverse effects; Edema/pathology; Female; Glycosaminoglycans/analysis; Graves Disease/etiology; Graves Disease/pathology; Humans; Immunization/adverse effects; Immunoglobulins, Thyroid-Stimulating/biosynthesis; Male; Mice; Oculomotor Muscles/pathology; Th2 Cells/immunology; Thyrotropin/blood; Thyroxine/blood; Vaccines, DNA/adverse effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Autoimmune Diseases / Receptors, Thyrotropin / Graves Disease / Disease Models, Animal Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Clin Invest Year: 2000 Type: Article Affiliation country: Belgium

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